Metabolic activation of the antidepressant tianeptine. I. Cytochrome P-450-mediated in vitro covalent binding

Biochemical Pharmacology

Volumn 38, Issue 19, 1989, Pages 3241-3246

  Letteron, Philippe ^a   Descatoire, Veronique ^a   Tinel, Marina ^a   Maurel, Patrick ^b   Labbe, Gilles ^a   Loeper, Jacqueline ^a   Larrey, Dominique ^a   Freneaux, Eric ^a   Pessayre, Dominique ^a  

^a BEAUJON HOSPITAL   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; CARBON MONOXIDE; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE; DEXAMETHASONE; GLUTATHIONE; ISOSAFROLE; OXYGEN; PHENOBARBITAL; PIPERONYL BUTOXIDE; PROADIFEN; PYRAZOLE; QUINIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TIANEPTINE; TROLEANDOMYCIN;

ANIMAL CELL; COVALENT BOND; ENZYME INDUCTION; FEMALE; HAMSTER; LIVER MICROSOME; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMAL; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; HAMSTERS; IN VITRO; MALE; MESOCRICETUS; MICE; MICROSOMES, LIVER; RATS; RATS, INBRED STRAINS; THIAZEPINES;

EID: 0024470867     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(89)90620-5     Document Type: Article

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