Use and abuse of khat (catha edulis): A review of the distribution, pharmacology, side effects and a description of psychosis attributed to khat chewing

Psychological Medicine

Volumn 19, Issue 3, 1989, Pages 657-668

  Pantelis, Christos ^a   Hindler, Charles G ^a   Taylor, John C ^a  

^a Royal Free and Friern Hospitals ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; CATHA EDULIS; EPHEDRINE;

ADULT; CASE REPORT; DRUG ABUSE; HIGHER PLANT; HOMICIDE; HUMAN; LEGAL ASPECT; MALE; PSYCHOLOGICAL ASPECT; PSYCHOSIS; SUICIDE;

ADULT; CASE REPORT; CATHA; CENTRAL NERVOUS SYSTEM STIMULANTS; CHEMISTRY; HUMAN; MALE; PLANT EXTRACTS; PSYCHOSES, SUBSTANCE-INDUCED; RECURRENCE; SUBSTANCE-RELATED DISORDERS; SUICIDE, ATTEMPTED; VIOLENCE;

EID: 0024461421     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291700024259     Document Type: Article

References (76)

1. Ahmed, A. M., Anania, M. C. & Nencim, P. (1983). Long lasting analgesic effect of cathinone. In International Conference On Khat The Health and Socioeconomic Aspects of Khat Use, January 17 21, pp. 144–147. International Council on Alcohol and Addictions: Madagascar.
2. Al-Thani, I. M. (1983). Development: the Saudi solution for the problem of khat. In International Conference On Khat — The Health and Socioeonomic Aspects of Khat Use, January 17 21, pp. 181 194. International Council on Alcohol and Addictions: Madagascar.
3. Baasher, T. A. (1980). The use of khat: a stimulant with regional distribution. In Drug Problems in the Sociocultural Context — A Basis for Policies and Programme Planning (ed. G. Edwards & A. Arif), pp. 86–93. World Health Organization: Geneva.
4. Baasher, T. A. & Sadoun, R. (1983). The epidemiology of khat. In International Conference On Khat — The Health and Socioeconomic Aspects of Khat Use, January 17–21, pp. 161–177. International Council on Alcohol and Addictions: Madagascar.
5. Braenden, O. (1979). Research on the chemical composition of khat. In Problems of Drug Dependence. NIDA Research Monograph, 27, 320–321. US Government Printing Office: Washington.
6. Busby, A. (1987). On sale: leaf drug that led to death. The Observer, 18 October, p. 5.
7. Carothers, J. C. (1945). Miraa as a cause of insanity. The East African Medical Journal 22, 4–6.
8. Chapple, P. A. L. (1965). New drugs of addiction. British Medical Journal 2, 108.
9. Connell, P. H. (1958). Amphetamine Psychosis. Institute of Psychiatry, Maudsley Monographs No. 5. Oxford University Press: Oxford.
10. Critchlow, S. & Seifert, R. (1987), Khat-induced paranoid psychosis. British Journal of Psychiatry 150, 247–249.
11. De Hondt, H. A., Fahmy, A. M. & Abdelbaset, S. A. (1984). Chromosomal and biochemical studies on the effect of kat extract on laboratory rats. Environmental Mutagenesis 6, 851 860.
12. Dhadphale, M. & Arap Mengech, H. N. K. (1987). Khat-induced paranoid psychosis. British Journal of Psychiatry 150, 876.
13. Dhadphale, M., Arap Mengech, H. N. K. & Chege, S. W. (1981). Miraa (Catha edulis) as a cause of psychosis. The East African Medical Journal 58 130–135.
14. D’Orbȧn, P. T. (1986). The consequences and effectiveness of drugs legislation. Family Law 16, 221–225.
15. Dougherty, R. J. (1982). Pseudo-speed, look-alikes or pea-shooters. New York State Journal of Medicine 82, 74–75.
16. Eddy, N. B., Halbach, H., Isbell, H. & Seevers, M. H. (1965). Drug dependence: its significance and characteristics. Bulletin of World Health Organization 32, 721–733.
17. El-Guindy, M. K. (1971). Effects of Catha edulis (khat) chewing on the human body. Journal of the Egyptian Medical Association 54, 230–234.
18. Ellinwood, Jr., E. H. (1969). Amphetamine psychosis: a multidimensional process. Seminars In Psychiatry 1, 208–226
19. Ellinwood, Jr., E. H. (1971). Assault and homicide associated with amphetamine abuse. American Journal of Psychiatry 127, 1170–1175.
20. Elmi, A. S. (1983a). The chewing of khat in Somalia. Journal of Ethnopharmacology 8, 163–176.
21. Elmi, A. S. (1983b). Khat consumption and problems in Somalia. In International Conference On Khat — The Health and Socioeconomic Aspects of Khat Use, January 17–21, pp. 78–86. International Council on Alcohol and Addictions: Madagascar.
22. Elmi, A. S. (1983 c). Effect of khat on resting and fatigued subjects. In International Conference On Khat — The Health and Socioeconomic Aspects of Khat Use, January 17–21, pp. 153–158.
23. Gendron, Y., Ardouin, Ch. & Martine, J. (1977). Accidents cardio-vasculaires aigus declenches par le khat. Médecine Tropicale 37, 69–72.
24. Giannini, A. J. & Castellani, S. (1982). A manic-like psychosis due to khat. Journal of Toxicology 19, 455–459.
25. Giannini, A. J., Burge, H., Shaheen, J. M. & Price, W. A. (1986). Khat: another drug of abuse? Journal of Psychoactive Drugs 18, 155–158.
26. Gold, M. S. & Bowers, M. B. Jr. (1978). Neurobiological vulnerability to low-dose amphetamine psychosis American Journal of Psychiatry 135, 1546–1548.
27. Gough, S. P. & Cookson, I. B. (1984). Khat-induced schizophreniform psychosis in UK. The Lancet 1, 455.
28. Gough, S. P. & Cookson, I. B. (1987). Khat-induced paranoid psychosis. British Journal of Psychiatry 150, 875–876.
29. Halbach, H. (1972). Medical aspects of the chewing of khat leaves. Bulletin of World Health Organization 47, 21–29.
30. Halbach, H. (1979). Khat — the problem today. In Problems of Drug Dependence, Proceedings of the 41st Annual Scientific Meeting, pp. 318–319. National Institute of Drug Abuse, US Government Printing Office, Washington, DC. Research Monograph No. 27.
31. Hodgkinson, R. (1962). A study of the clinical effects of Catha eduhs (khat, miraa) in Kenya. The Medical Journal of Australia 49, 884–886.
32. Hogg, A. & Rogers, H. (1985). Arab danger drug on sale legally in Britain. The Sunday Times, 20 January, pp. 1–2.
33. Jaffe, J. H. (1980). Commonalities and diversity among drug-use patterns in different countries. In Drug Problems In the Sociocultural Context — A Basis for Policies and Programme Planning (ed. G. Edwards & A. Arif), pp. 94–102 World Health Organization: Geneva.
34. Kalix, P. (1980). Hyperthermic response to (-) cathinone, an alkaloid of Catha eduhs (khat). Journal of Pharmacy and Pharmacology 32, 662–663.
35. Kalix, P. (1983 a). Mechanism of action of (-) cathinone, a new alkaloid from khat leaves. Alcohol and Alcoholism 18, 301–303.
36. Kalix, P. (1983b). The pharmacology of khat and of the khat alkaloid cathinone. In International Conference On Khat — The Health and Socioeconomic Aspects of Khat Use, January 17–21, pp. 140–143. International Council on Alcohol and Addictions, Madagascar.
37. Kalix, P. (1984 a). The pharmacology of khat. General Pharmacology 15, 179–187.
38. Kalix, P. (1984b). Amphetamine psychosis due to khat leaves. The Lancet 1, 46
39. Kalix, P. (1987). Khat: scientific knowledge and policy issues. British Journal of Addiction 82, 47–53.
40. Kalix, P. & Braenden, O. (1985). Pharmacological aspects of the chewing of khat leaves. Pharmacological Reviews 37, 149–164.
41. Kennedy, J. G., Teague, J. & Fairbanks, L. (1980). Qat use in North Yemen and the problem of addiction: a study in medical anthropology Culture, Medicine and Psychiatry 4, 311–344.
42. Kennedy, J. G., Teague, J., Rokaw, W. & Cooney, E. (1983). A medical evaluation of the use of qat in North Yemen. Society Science and Medicine 17, 783–793.
43. Kennedy, J. G. (1987). The Flower of Paradise — The Institutionalized Use of the Drug Qat In North Yemen. D. Reidel: Dordrecht.
44. Knoll, J. (1979). Studies on the central effects of (-) cathinone. Problems of Drug Dependence-Proceedings of the 41st Annual Scientific Meeting, pp. 322–323. National Institute of Drug Abuse, US Government Printing Office: Washington, DC. Research Monograph No. 27.
45. Krikorian, A. D. (1984). Kat and its use: an historical perspective. Journal of Ethnopharmacology 12, 115–178.
46. Laurent, J. M. (1962 a). Consequences medicales de la toxicomanie au cath, Medecine Tropicale 23, 477–483.
47. Laurent, J. M. (1962b) Toxique et toxicomanie peu connus, ‘Le cath’ Annales Medecine Psychiatrie, December, 649–657.
48. Luqman, W. & Danowski, T. S. (1976). The use of khat (Catha edulis) in Yemen. Social and medical observations. Annals of Internal Medicine 85, 246–249.
49. McKee, C. M. (1987). Medical and social aspects of qat in Yemen: a review. Journal of the Royal Society of Medicine 80, 762–765.
50. McLaren, P. (1987). Khat psychosis. British Journal of Psychiatry 150, 712-713.
51. Mancioli, M. & Parrinello, A. (1967). Il qat (Catha edulis). La Clinica Terapeutica 43, 103–172.
52. Margetts, E. L. (1967). Miraa and myrrh in East Africa — clinical notes about Catha edulis. Economic Botany 21, 358–362.
53. Mayberry, J., Morgan, G. & Perkin, E. (1984). Khat-induced schizophreniform psychosis in UK. The Lancet 1, 455.
54. Murad, F. (1983). Social effects of khat. In International Conference On Khat — The Health and Socioeconomic Aspects of Khat Use, January 17–21, pp. 211–214. International Council on Alcohol and Addictions: Madagascar.
55. Nencim, P., Anania, M. C., Abdullahi, M. A., Amiconi, G. & Elmi, A. S. (1983), Physiological and neuroendocrine effects of khat in man. In International Conference On Khat — The Health and Socioeconomic Aspects of Khat Use, January 17–21, pp. 148–152, International Council of Alcohol and Addictions: Madagascar.
56. Nencini, P., Abdullahi, M. A., Amiconi, G., Elmi, A. S. (1984a). Tolerance develops to sympathetic effects of khat in humans. Pharmacology 28, 150–154.
57. Nencini, P., Abdullahi, M. A., Anania, M. C., Moscucci, M. & Paroli, E. (1984b). Prolonged analgesia induced by cathinone. The role of stress and opioid and nonopioid mechanisms. Pharmacology 29, 269–281.
58. Nencini, P., Amiconi, G., Befani, O., Abdullahi, M. A. & Anania, M. C. (1984 c). Possible involvement of amine oxidase inhibition in the sympathetic activation induced by khat (Catha edulis) chewing in humans. Journal of Ethnopharmacology 11, 79–86.
59. Omolo, O. E. & Dhadphale, M. (1987 a). Prevalence of khat chewers among primary health clinic attenders in Kenya. Acta Psychiatrica Scandinavica 75, 318–320.
60. Omolo, O. E. & Dhadphale, M. (1987b). Alcohol use among khat (Catha) chewers in Kenya. British Journal of Addiction 82, 97–99.
61. Rosecrans, J. A., Campbell, O. L., Dewey, W. L. & Harris, L. S. (1979). Discnminative stimulus and neurochemical mechanism of cathinone: a preliminary study. In Problems of Drug Dependence, Proceedings of the 41st Annual Scientific Meeting, pp. 328–329 National Institute of Drug Abuse, US Government Printing Office: Washington, DC. Research Monograph No. 27.
62. Schorno, X. & Steinegger, E. (1979). CNS-active phenylpropylamines of Catha edulis of Kenyan origin. Experientia 35, 572–574.
63. Schuster, C. R. & Johanson, C. E. (1979). Behavioural studies of cathinone in monkeys and rats. In The Problems of Drug Dependence, Proceedings of the 41st Annual Scientific Meeting, pp. 324–325. National Institute of Drug Abuse, US Government Printing Office: Washington, DC. Research Monograph No. 27.
64. Shanhandeh, B., Geadah, R., Tongue, A., Tongue, E. & Rolli, J. (1983). The health and socioeconomic aspects of khat use. In Proceedings, First International Conference on Khat. International Council on Alcohol and Addictions: Lausanne.
65. Siegel, R. K. (1980). Cocaine substitutes. The New England Journal of Medicine 302, 817–818.
66. Snyder, S. H. (1973). Amphetamine psychosis: a model schizophrenia mediated by catecholamines. American Journal of Psychiatry 130, 61–67.
67. Szendrei, K. (1980). The chemistry of khat. Bulletin of Narcotics 32, 5–36.
68. United Nations Document MNARfll, (1975). Etudes sur la composition chimique du khat; récherches sur la fraction phenyl-alkylamine.
69. Weir, S. (1985). Qat in Yemen-Consumption — Consumption and Social Change. British Museums Publications: London.
70. Whitehouse, A. M. (1987). Should sympathomimetics be available over the counter? British Medical Journal 294, 1308.
71. Whitehouse, A. M. & Duncan, J. M. (1987). Ephedrine psychosis rediscovered. British Journal of Psychiatry 150, 258–261.
72. WHO Expert Committee on Drug Dependence (1973). Nineteenth Report, World Health Organization Technical Report Series, No. 526.
73. WHO Advisory Group (1980). Review of the pharmacology of khat. Bulletin on Narcotics 32, 83–93.
74. WHO Expert Committee on Drug Dependence (1985). Twenty-second Report, World Health Organization Technical Report Series, No. 729.
75. Yanagita, T. (1979). Sympathomimetic effects of khat. In Problems of Drug Dependence (ed. L. S. Harris), pp. 326–327. National Institute of Drug Abuse, Research Monograph Series, 27: Rockville, Maryland.
76. Zelger, J. L., Schorno, Hj. X. & Carlini, E. A. (1980). Behavioural effects of cathinone, an amine obtained from Catha edulis Forsk.: comparisons with amphetamine, norpseudoephedrine, apomorphine and nomifensine Bulletin on Narcotics, Vol. XXXII, No. 3, 67–81.