Gamma heavy chain "disease": Heterogeneity of the clinicopathologic features report of 16 cases and review of the literature

Medicine (United States)

Volumn 68, Issue 6, 1989, Pages 321-335

  Fermand, Jean Paul ^a   Brouet, Jean Claude ^a   Danon, Francoise ^a   Seligmann, Maxime ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DOXORUBICIN; PREDNISONE; VINCRISTINE SULFATE;

ADULT; AGE; AUTOIMMUNITY; CLINICAL ARTICLE; DIAGNOSIS; DRUG THERAPY; FEMALE; HEAVY CHAIN DISEASE; HISTOLOGY; HUMAN; LYMPH NODE; MALE; PRIORITY JOURNAL; RHEUMATIC DISEASE;

ADULT; AGED; AGED, 80 AND OVER; BONE MARROW; CASE REPORT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HEAVY CHAIN DISEASE; HUMAN; IMMUNOELECTROPHORESIS; IMMUNOGLOBULINS, GAMMA-CHAIN; LYMPHOID TISSUE; MALE; MIDDLE AGE;

EID: 0024458885     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/00005792-198911000-00001     Document Type: Article

References (101)

1. Adlersberg JB, Grann V, Zucker-Franklin D. Frangione B, Franklin EC. An unusual case of a plasma cell neoplasm with an IgG3 λ myeloma and a gamma 3 heavy chain disease protein. Blood 51:85-96,1978
2. Alexander A, Anicito I, Buxbaum J. Gamma heavy chain disease in man: Genomic sequence reveals two non-contiguous deletions in a single case. J Clin Invest 82:1244-52,1988
3. Alexander A, Barritault D, Buxbaum J. Gamma heavy chain disease in man: Translation and partial purification of mRNA coding for the deleted protein. Proc Natl Acad Sci (USA), 75:4774-78,1978
4. Baker AS, Lankford P, Krantz SB, Buchanan RD. Gamma heavy chain disease-presenting as pancytopenia and splenomegaly. South Med J 70:495-97,1977
5. Bakhshi A, Guglielmi P, Siebenlist U, Ravetch JV, Jensen JP and Korsmeyer SJ. A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a μ heavy chain disease protein. Proc Natl Acad Sci (USA) 83:2689-93,1986
6. Bartoloni C, Flamini G, Gentiioni N, Russo MA, Barone C, Gam-bassi G, Terranova T. Immunochemical and ultrastructural study of MM with a heavy chain protein in the serum. J Clin Pathol 33:936-45,1980
7. Bender SW, Danon F, Preud'homme JL, Posselt HG, Roettger P, Seligmann M. Gamma heavy chain disease simulating alpha chain disease. Gut 19:1148-52,1978
8. Bentaboulet M, Mihaesco E, Gendron MC, Brouet JC, Tsapis A. Genomic alterations in a case of alpha chain disease leading to the generation of composite exons from the JH region. Europ J Immunol 19: (in press), 1989.
9. Bloch KJ, Lee L, Mills JA, Haber E. Gamma heavy chain disease an expanding clinical and laboratory spectrum. Am J Med 55:61-70,1973.
10. Briet E, Van Nieuwkoop JA, Jol V.D. Zijde CM, Den Ottolander GJ, Radi J. Chronic lymphocytic leukemia and IgG HCD. Scand J Haematol 25:244-50,1980
11. Buxbaum JN, Preud'homme JL. Alpha and gamma heavy chain diseases in man: Intracellular origin of the aberrant polypeptides. J Immunol 109:1131-37,1972
12. Carbonara AO, Paolino W, Malavasi F, Levis A, Stramignoni A, de Lange G, van Loghem E, Franklin EC. A new case of gamma heavy chain disease: Clinical, immunochemical and structural characterization. Vox Sang 37:89-95,1979
13. Case records of the Massachusetts General Hospital (Case 50-1970). N Engl J Med 283:1332-39,1970
14. Cattan D, Belaiche J, Cabane J, Laget PF, Vesin P, Bousser MG, Wautier JL. Maladie des chames lourdes gamma avec auto-anticorps multiples et neuropathie périphérique. Ann Méd Interne 131:213-16,1980
15. Chiba K, Matsumoto J, Konno N, Oka T, Kasukawa R, Suzuki S. Gamma-chain disease associated with rheumatoid arthritis. Ryumachi 22:129-36,1982
16. Chury Z, Jansa P, Jedličkova J, Rozprimova I, Sabacky J. A contribution to Franklin's disease. Folia Haematol (Leipz) 96:43-58,1971.
17. Cogné M, Bakhshi A, Korsmeyer S, Guglielmi P. Gene mutations and alternate RNA slicing result in truncated Ig light chains in human gamma heavy chain disease. J Immunol 141:1738-44,1988.
18. Cozzolino F, Vercelli D, Castigli E, Becucci A, Di Guglielmo R. A new case of gamma HCD. Clinical and immunochemical studies. Scand J Haematol 28:145-50,1982
19. Creyssel R, Brizard CP, Gibaud A, Cordier JF, Gibaud M. Maladie des chames lourdes gamma d'apparition secondaire au cours de Involution d'une macroglobulinémie. Lyon Med 237:215-20,1977
20. Dammacco F, Rigoli E, Ferrarese M, Bonomo L. Gamma heavy chain disease in a young girl. Haematologica (Pavia), 61:278-90,1976.
21. Delmas-Marsalet Y, Voisin D, Hennache G, Bauters F, Goudemand M. Etude clinique et biologique de la maladie des chaines lourdes gamma: A propos d'une nouvelle observation. Nouv Rev Fr Haematol 11:717-34,1971
22. Doe WF, Danon F, Seligmann M. Immunodiagnosis of alpha chain disease. Clin Exp Immunol 36:189-97,1979
23. Eisner SB, Mitnick PD. Hypercalcemia and reversible renal failure in HCD. Southern Medical Journal 79:507-9,1986
24. Ellman LL, Bloch KJ. Heavy-chain diaeaae: Report of a seventh case. N Engl J Med 278:1195-1201,1968.
25. Faguet G, Barton BP, Smith LL, Garver FA. Gamma heavy chain disease: Clinical aspects and characterization of a deleted, nonco-valently linked y I heavy chain dimer (BAZ). Blood 49:495-505,1977.
26. Felman P, Bryon PA, Revol L, Creyssel R, Roda L. Maladie de Franklin: Remission apres trois mois de chlorambucil. Nouv Press Med 6:3647,1977
27. Feremans W, Caudron M, Bieva C. A case of y 3 heavy chain disease with vacuolated plasma cells: A clinical, immunological and ultra-structural study. J Clin Pathol 32:334-43,1979
28. Fine JM, Zakin MM, Faure A, Boffa G. Myélome avec paraprotéine sérique y G et elimination urinaire d'un fragment de ▪» G dépourvu de chaines légěres. Rev Fr Etud Clin Biol 13:175-78,1968
29. Forte FA, Prelli E, Yount W, Jerry LM, Kochwa S, Franklin EC, Kunkel HG. Heavy chain disease of the mu type. Report of the first case. Blood 36:137-44,1970
30. Frangione B, Franklin EC. Heavy chain diseases: Clinical features and molecular significance of the disordered immunoglobulin structure. Semin Hematol 10:53-64,1973
31. Franklin EC, Frangione B. Structural variants of human immunoglobulins. In: Inman FP, ed.Comtemporary Topics in Molecular Immunology. Vol 4. New York: Plenum Press, pp. 89-125,1975.
32. Franklin EC, Lowenstein J, Bigelow B, Meitzer M. Heavy chain disease-a new disorder of serum γ-globulins: Reports of the first case. Am J Med 37:332-50,1964.
33. Galian A, Lecestre MJ, Scotto J, Bognel C, Matuchansky C, Ram-baud JC. Pathological study of alpha chain disease with special emphasis on evolution. Cancer 39:2081-2101,1977.
34. Gallart MT, Cannale J, Canadell E, Cortez L, Moragas A, Schwartz S. A new case of gamma-heavy chain disease. Acta Haematol (Basel) 59:262-76,1978
35. Gaucher A, Bertrand F, Brouet JC, Pourel J, Netter P, Faure G, Seligmann M. Maladie des chaines Iourdes gamma associée ä une polyarthrite rhumatoide: Disparition spontanee de la proteine path· ologique. Sem Hop Paris 53:2117-20,1977.
36. Guglielmi P, Bakhshi A, Cogně M, Seligmann M, Korsmeyer SJ. Multiple genomic defects result in an alternative RNA splice creating a human gamma HCD protein. J Immunol 141:1762-68,1988.
37. Harousseau JL, Flandrin G, Tricot G, Brouet JC, Seligmann M, Bernard J. Malignant lymphoma supervening in chronic lymphocytic leukemia and related disorders. Richter's syndrome: A study of 25 cases. Cancer 15:1302-8,1981
38. Ibuka T, Shimoyama M, Sakano T, Sakai Y, Kimura K, Mukojimi T, Ooboshi S. Gamma-heavy chain disease; report of a case. Jpn J Clin Hematol 15:671-72,1974
39. Imamura Y, Mukohjima T, Kimura K. A case of heavy chain disease. Acta Haematol Jpn 32:814-15,1969
40. Isobe T, Osserman EF. Plasma cell dyscrasia associated with the production of incomplete (?deleted) IgG λ molecules, gamma heavy chains, and free lambda chains containing carbohydrate: Description of the first case. Blood 43:505-26,1974.
41. Iwase S, Miyashita H, Tsunoo C, Takakuwa T, Hara H, Honda M, Masugi Y, Imamura Y. An autopsy case of gamma HCD showing histological features similar to angio-immunoblastic lymphadenop-athy with dysproteinemia. Rinsho Ketsueki 23:1757-65,1982.
42. Jacqueline F, Renversez JC, Groslambert P, Fine JM. Maladie des chaines Iourdes gamma au cour« d'une polyarthrite rhumatoide: Ètude clinique et immunochimique. Rev Rhum Mal Osteoartic 45:661-65,1978
43. Jones WG, Elvy RJ, Pedersen N. Heavy chain disease in Australia. Lancet 1: 570,1974.
44. Kanoh T, Nakasato H. Osteolytic gamma heavy chain disease. Eur J Haematol 39:60-65,1987.
45. Katsuki A, Hujitani S, Torii Y, Nakata T, Noguchi K, Yamano H, Tanizawa Y, Kinoshita S, Kawasaki H, Shiraki T. Gamma heavy chain disease (report of the 6th case in Japan)-Special reference on clinicopatholo-immunological findings compared with prior cases. Igaku-No-Ayumi 99:82,1976
46. Keller H, Spengler GA, Skvaril F, Flury W, Noseda G, Riva G. Zur Frage der heavy chain diseaae: Ein Fall von IgG-heavy-chain-Fragment und IgM-Typ K-Paraproteinämie mit Plasmazellenleukämie. Schweiz Med Wochenschr 100:1012-22,1970.
47. Kretschmer RR, Pizzuto J, Gonzales J, Lopez OM. Heavy chain disease, rheumatoid arthritia and cryoglobulinemia. Clin Immunol Immunopathol 3:195-215,1974.
48. Kuroyanagi T, Kura K, Akamatau Y, Arao T. A ease report of the immunodysplasia syndrome and heavy chain disease associated with subacute bacterial endocarditis. Tohoku J Ezp Med 128:325-31,1979.
49. Kyle RA, Greipp PR, Banka PM. The diverse picture of gamma heavy chain disease. Report of seven cases and review of literature. Mayo Clin Proc 56:439-51,1981.
50. Lebreton JP, Rivat C, Rivat L, Guillemot L, Ropartz C. Une im-munoglobulinopathie meeonnue: La maladie des chaines lourdes. Presse Med 75:2251-54,1967.
51. Lenders JW, Holdrinet RS, Nguyen CT, De Waal R. A caae of gamma heavy chain monoclonal gammopathy of undetermined significance. Netherlands J Med 27:412-16,1984.
52. Loyau G, Barre JP, L'Hirondel JL, Laniece M, Preud'homme JL. Maladie des chaines lourdes gamma: A propos d'une nouvelle observation. Nouv Presse Med 4:957-59,1975.
53. Lyons RM, Chaplin H, Tillack TW, Majerua PW. Gamma heavy chain diseaae: Rapid, sustained response to cyclophosphamide and prednisone. Blood 46:1-9,1975.
54. Marceno R, Majolino I, Cavallaro AM, Caronia F. An unusual case of plasma cell dyscrasia with gamma heavy chains in the serum and free kappa chains in the urine. Haematologiea 69:715-20,1984.
55. Marsh WL, Worthman JW, Spiegelberg HL. The pathology of gamma heavy chain diaeaae. Report of a case with morphologic progression from lymphocytic to plasmacytic proliferation. Cancer 47:2878-82,1981
56. Matsubayashi S, Tamai H, Suzuki T, Matauzuka F, Miyauchi A, Kobayashi N, Fukata S, Kuma K, Yanaihara N, Nagataki S. Extra-medullary plasmacytoma of the thyroid gland producing gamma heavy chain. Endocrinologia Japonica 32:427-33,1985
57. Mihaesco E, Guglielmi P, Brouet JC, Mihaesco C. Biochemical and biosynthetic studies of a crystallizable human gamma-1 heavy chain diaeaae protein. Scand J Immunol 18:145-52,1983.
58. Murphy WM, Deodhar SD, Battle JD Jr. Heavy chain diseaae: Report of a case. Cleve Clin Q 39:73-78,1972.
59. Ockhuizen T, Jilderda JF, Cazemier T. Sequential development of Waldenstrom'« macroglobulinemia and gamma-1 heavy chain diaeaae in a single patient. Clinical immunochemical, immunofluorescent and protein studies. Acta Haematol 71:53-59,1984.
60. Ockhuizen T, Smit JW, Van Leeuwen M. Rheumatoid arthritia associated with transient gamma-2 heavy chain diaeaae. Rheumatology Int 3:167-72,1983.
61. O'Conor GT Jr, Wyandt HE, Innes DJ, Normansell DE, Heaa CE. Gamma heavy chain disease; report of a case associated with trisomy of chromosome 7. Cancer Genet Cytogenet 15:1-5,1985.
62. Ogawa K, Imai M, Tanigawa T, Tsuji T, Arima T. Pathological studies on a long-term survived caae of gamma heavy chain diseaae: A brief review of 30 reported caaea and a proposal for histological typing. Acta Pathol Jpn 28:759-78,1978.
63. Okuda K, Himeno Y, Toyama T, Ohta M, Kitagawa M, Sugai S. Gamma heavy chain diaeaae and giant lymph node hyperplasia in a patient with impaired T cell function. Jpn J Med 21:109-14,1982.
64. Oaaerman EF, Takatauki K. Clinical and immunochemical atudies of four cases of heavy (H>2) chain disease. Am J Med 37:351-73,1964
65. Otto S, Peter I, Vegh S, Juhoa E, Beaznyak I. Gamma heavy chain diaeaae with primary thyroid plaamacytoma. Arch Pathol Lab Med 110:893-96,1986
66. Papac RJ, Rosenstein RW, Richarda F, Yesner R. Gamma heavy chain diaeaae aeen initially aa gaatric neoplaam. Arch Intern Med 138:1151-53,1978.
67. Paatuazak WT, Scholea JV, Koaciol C, Cartun R. Gamma heavy chain diaeaae. Where the heavy chaina ariae. Am J Clin Pathol 79:520-21,1983
68. Pontet F, Guě X, Dosquet C, Caen J, Rouaaelet F. Rapid evolution in the immunochemical findinga of gamma heavy chain diaeaae. Clinical Chemiatry 34:439-43,1988.
69. Preud'homme JL, Brouet JC, Seligmann M. Cellular immunoglobulins in human y and a heavy chain diseases. Clin Ezp Immunol 37:283-91,1979
70. Preud'homme JL, Hurez D, Danon F, Brouet JC, Seligmann M. Intracytoplaamic and aurface bound immunoglobulina in "nonsecreto ry" and Elence Jonea myeloma. Clin Exp Immunol 25:428-36,1976
71. Preud'homme JL, Morel-Maroger L, Brouet JC, Cerf M, Mignon F, Guglielmi P, Seligmann M. Syntheaia of abnormal immunoglobulina in lymphoplasmacytic disorders with visceral light chain deposition. Am J Med 69:703-10,1980.
72. Prévot P, Loyau G, Héron JP, L'Hirondel JL, Chaix G, Lanièce M, Brouet JC, Danon F, Seligmann M. Maladie des chaines lourdes gamma: Une nouvelle observation avec prolifération plasmocytaire et lacunes crániennes. Ann Med Interne (Paris) 128:151-57,1977.
73. Pruzanski W, Parr DM, Prchal J, Chan EYP. Gamma-3 heavy chain disease in a young patient with Down syndrome: Study of peripheral blood lymphocytes and of susceptibility to infection. Clin Immunol Immunopathol 12:253-62,1979.
74. Rabin BS, Moon J. Clinical findings in a case of newly defined gamma heavy chain disease protein. Clin Exp Immunol 14:563-68,1973
75. Roda L, David MJ, Biron P, Souche S, Creyssel R. Gamma heavy chain disease DUB: Clinical, immunochemical and pathological studies. Haematologica 70:232-35,1985.
76. Roda L, David MJ, Souche S, Coiffier B, Creyssel R. Gamma-3 heavy chain disease and monoclonal IgMK in a patient with a gastrointestinal lymphoma. Haematologica 70:115-19,1985.
77. Rouesse J, Gerard-Marchant R, Chevalier A, Seligmann M. Maladie dee chaines lourdes gamma avec atteinte thyroidienne. Rev Eur Etud Clin Biol 17:405-11,1972
78. Ruiz-Arguelles A, Valls de Ruiz M. Dominguez-Barranco A, Ruiz-Arguelles G, Ruiz-Reyes G. "Incomplete" pyroglobulin-gamma disease in a patient with osteosclerotic myeloma. Scand J Haematol 33:351-55,1984
79. Saruta E, Naganawa K, Kojima I, Kim Y, Hikida T, Ohshima S, Kohno K, Tsuchiya T. A case of gamma heavy chain disease having interesting course. Proc 4th Congr Jap Soc Clin Immunol. Vol. 97,1976.
80. Seligmann M. Heavy chain diseases. Rev Eur Etud Clin Biol 17:349-55,1972
81. Seligmann M, Rambaud JC. Alpha chain disease: An immunoproli-ferative disease of secretory immune system. Ann NY Acad Sci 409:478-84,1983
82. Seligmann M, Danon F, Hurez D, Mihaesco E, Preud'homme JL. Alpha chain disease: A new immunoglobulin abnormality. Science 162:1396-97,1968
83. Seligmann M, Mihaesco E, Chevalier A, Miglierina R. Immunochemical study of a human myeloma IgGl half molecule. Ann Immunol (Inst Pasteur) 129C: 855-70, 1978.
84. Seligmann M, Mihaesco E, Hurez D, Mihaesco C, Preud'homme JL, Rambaud JC. Immunochemical studies in four cases of alpha chain disease. J Clin Invest 48:2374-89,1969
85. Seligmann M, Mihaesco E, Preud'homme JL, Danon F, Brouet JC. Heavy chain diseases: Current findings and concepts. Immunol Rev 48:147-67,1979
86. Shirakura T, Kobayashi Y, Murai Y, Inoue T, Imamura Y. A case of gamma heavy chain disease associated with autoimmune hemolytic anaemia: Clinical, haematological, immunological and pathological details. Scand J Haematol 16:387-93,1976
87. Silva-Moreno M, Ruiz-Arguelles G, Lopez-Karpovitch X, Labardini-Mendez J. Heavy chain disease. Report of four cases. Sangre 28:89-98,1983
88. Soiling K, Askjaer SA. Multiple myeloma with urinary excretion of heavy chain components of IgG and nodular glomerulosclerosis. Acta Med Scand 194:23-30,1973.
89. Stühlinger W, Berek K, Lapin A, Jaschke E, Pastner D. Gamma-1 heavy chain disease with immune vasculitis and rheumatoid arthritis. Klinische Wochenschrift 65:359-68,1987.
90. Tsapis A, Bentaboulet M, Pellet P, Mihaesco E, Thierry D, Seligmann M, Brouet JC. The productive gene for alpha-HCD protein MAL is highly modified by insertion-deletion processes. J Immunol (in press), 1989.
91. Usui M, Nariuchi H, Matuhasi T, Takahashi R, Adachikara K, Koide O. A case of Fc-fragment disease. Jpn J Exp Med. 41:83-87,1971
92. Vadstrup S. Tung kaede syndromer: En kort oversigt og et tilfaelde af IgG tung kaede sygdom ("heavy chain disease"). Ugeskr Laeger 135:1330-32,1973
93. Van Bergeijk L, Biewenga J, Langenhuijsen MMAC. Gamma heavy chain disease with an unusually benign course. Clin Lab Haematol 2:83-88,1980
94. Virella G, Monteiro JMN, Lopes-Virella MF, Soares AD, Fudenberg HH. Asynchronous development of two monoclonal proteins (IgM λ and y I chains) in a patient with abdominal lymphoma. Cancer 39:2247-53,1977
95. Von Baehr R, Schwenke H. Bericht über einen Fall von Franklin-Disease-7-Schwerkettenkrankheit. Z Gesamte Inn Med 30:28-31,1975
96. Wager O, Rasanen JA, Lindeberg L, Mäkelä V. Two cases of IgG heavy-chain disease. Acta Pathol Microbiol Scand 75:350-52,1969
97. Wester SM, Banks PM, Chin-Yang Li. The histopathology of y heavy chain disease. Am J Clin Pathol 78:427-36,1982.
98. Westin J, Eyrich R, Falsen E, Lindholm L, Lundin P, Lönnroth I, Weinfeld A. Gamma heavy chain disease: Reports of three patients. Acta Med Scand 192:281-92,1972
99. Woods R, Blumenschein GR, Terry WD. A new type of human gamma heavy chain disease protein: Immunochemical and physical characteristics. Immunochemistry 7:373-81,1970.
100. Yavorkovsky LI, Pushkarev IA, Guseva LN, Magalif NL, Apine RY, Blumberga IA. A case of gamma heavy chain disease. Probi Gematol Pereliv Krovi 23:33-38,1978.
101. Zawadzki ZA, Benedek TG, Ein D, Easton JM. Rheumatoid arthritis terminating in heavy-chain disease. Ann Intern Med 70:335-47,1969.