The pharmacology of dichloroacetate

Metabolism

Volumn 38, Issue 11, 1989, Pages 1124-1144

  Stacpoole, Peter W ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DICHLOROACETIC ACID; LACTIC ACID;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HEMODYNAMICS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPERGLYCEMIA; INFANT; KIDNEY FUNCTION; LIPOGENESIS; MALE; METABOLISM; NEUROPATHY; NEWBORN; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT; REVIEW;

ACETIC ACIDS; AMINO ACIDS; ANIMAL; CARBOHYDRATES; CHEMISTRY, PHYSICAL; DICHLOROACETATE; HEMODYNAMICS; HUMAN; KIDNEY; LACTATES; LACTIC ACID; LIPIDS; LIPOPROTEINS; NEURONS; PERIPHERAL NERVOUS SYSTEM DISEASES; PROTEINS;

EID: 0024452528     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/0026-0495(89)90051-6     Document Type: Review

References (345)

1. Review of the pharmacologic and therapeutic effects of diisopropylammonium dichloroacetate (DIPA)
2. The metabolic effects of dichloroacetate
3. Zur Kolloidchemic und Pharmakologie der Keratinsubstanzen der Menschlichen Haut
4. Practical therapy for hyperkeratotic skin lesions
5. Monochloracetic acid as a food and beverage stabilizer
6. Lipotropic action of ethyl trichloracetate
7. The lipotropic action of some halogen derivatives of acetic acid
8. Gluconic acid (dialkylamino) acetates
9. Pangamic acid sodium: A newly isolated crystalline water-soluble factor. A preliminary report
10. 15). A review
11. [Dichloroacetate of diisopropylammonium as molecule responsible for several pharmacological activities attributed to the so-called pangamic acid].
12. Hypoglycaemic action of diisopropylammonium salts in experimental diabetes
13. Diisopropylamonium dichloroacetate (DIPA) and sodium dichloroacetate (DCA): Effect on glucose and fat metabolism in normal and diabetic tissue
14. Diisopropylammonium dichloroacetate (DIPA) and sodium dichloroacetate (DCA): Effects on intermediary metabolism in isolated rat liver parenchymal cells
15. [Pharmacological research on dilsopropylammonium dichloroacetate].
16. Hypoglycemic effect of diisopropylammonium dichloroacetate in humans
17. Diisopropylammonium dichloroacetate: Regulation of metabolic intermediates in muscle of alloxan diabetic rats
18. Treatment of streptozotocin diabetes with di-isopropylammonium dichloroacetate (DIPA)
19. Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis
20. Long term treatment of mild diabetes in streptozotocin diabetic rats with phenformin and dichloroacetate: Normoglycaemia with normal blood lactate concentration
21. Metabolic effects of sodium dichloroacetate in normal and diabetic dogs
22. Acute effects of dichloroacetate in the depancreatized dog: Glucose synthesis and turnover
23. The metabolic effects of sodium dichloroacetate in the starved rat
24. Prolonged hypolactatemia and increased total pyruvate dehydrogenase activity by dichloroacetate
25. Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydoxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo
26. Regulation of fatty acid oxidation in heart muscle effects of pyruvate and dichloroacetate
27. Relationship between glucose oxidation and glucose tolerance in man
28. Hepatic glycogen synthesis on carbohydrate re-feeding after starvation
29. Effects of gluconeogenic precursor flux alterations on glycogen resynthesis after prolonged exercise
30. The actions of dichloroacetic acid on blood glucose, liver glycogen and fatty acid synthesis in obesehyperglycaemic (ob/ob) and lean mice
31. Dichloroacetate-induced changes in liver of normal and diabetic rats
32. Effect of dichloroacetate on carbohydrate and lipid metabolism of isolated hepatocytes
33. Regulation of fructose-2, 6-bisphosphate and glycogen synthesis by dichloroacetate and phenazine methosulphate in rat adipose tissue
34. Dichloroacetate inhibits blycolysis and augments insulin-stimulated glycogen synthesis in rat muscle
35. Dichloroacetate: Effects on exercise endurance in untrained rats
36. Carbohydrate metabolism and lipid storage and breakdown in diabetes
37. Phosphofructokinase and the Pasteur effect
38. Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).
39. Regulation of pyruvate dehydrogenase (PDH) reaction in rat brain by dichloroacetate (DCA) and ATP
40. Evidence that a 41,000 dalton brain phosphoprotein is pyruvate dehydrogenase
41. Phosphorylation-mediated changes in pyruvate dehydrogenase activity influence pyruvate-supported calcium accumulation by brain mitochondria
42. The regulation of pyruvate dehydrogenase activity in rat hippocampal slices: Effect of dichloroacetate
43. Effects of Dichloroacetate on Brain Pyruvate Dehydrogenase
44. Effects of dichloroacetate on pyruvate metabolism in rat brain in vivo
45. Regulation of norepinephrine uptake by adenine nucleotides and divalent cations: Role for extracellular protein phosphorylation
46. Cellular effects of endotoxin in vitro. I. Effect of endotoxin on mitochondrial substrate metabolism and intracellular calcium.
47. Regulation of mammalian pyruvate dehydrogenases
48. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
49. Regulation of mammalian pyruvate dehydrogenase
50. Regulation of the human pyruvate dehydrogenase complex
51. Regulation of pyruvate dehydrogenase in rat heart
52. Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria
53. Studies on the regulation of pyruvate dehydrogenase in the isolated perfused rat heart
54. Regulation of the branched chain a-keto acid and pyruvate dehydrogenases in the perfused rat heart
55. Role of individual phosphorylation sites in inactivation of pyruvate dehydrogenase complex in rat heart mitochondria
56. Puruvate dehydrogenase activity in cardiac mitochondria from genetically diabetic mice
57. Dichloroacetate acid improves in vitro myocardial function following in vivo endotoxin administration
58. Effects of dichloroacetate on the mechanical function of the isolated ischemic heart
59. Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats
60. A device for the liberation and determination of 14-CO-2
61. Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria
62. Skeletal muscle fibers in suspension: A new approach to the study of oxidative and glycolytic metabolism in differentiated muscle
63. Accelerated loss of lean body mass in fasting rats due to activation of pyruvate dehydrogenase by dichloroacetate
64. Glucose kinetics and pyruvate dehydrogenase activity in septic rats treated with dichloroacetate
65. Metabolic effects of partial reversal of pyruvate dehydrogenase activity by dichloroacetate in sepsis
66. The Effect of Fatty Acids on the Regulation of Pyruvate Dehydrogenase in Perfused Rat Liver
67. Regulatory function of pyruvate dehydrogenase and the mitochondrion in lipogenesis
68. Effect of dichloroacetate and glucagon on the incorporation of labeled substrates into glucose and on pyruvate dehydrogenase in hepatocytes from fed and starved rats
69. Inhibition of hepatic gluconeogenesis by dichloroacetate
70. Dichloroacetate tissue concentrations and its relationship to hypolactatemia and pyruvate
71. Evidence that glucose induction of malic enzyme mRNA is mediated by a product of pyruvate oxidation
72. Monolayer culture of parenchymal rat hepatocytes on collagen-coated microcarriers. A hepatocyte system for short-and-long-term metabolic studies
73. Changes in the activity of active pyruvate dehydrogenase complex in the newborn of normal and diabetic rats
74. Effect of insulin on ketogenesis and fatty acid synthesis in rat hepatocytes incubated with dichloroacetate
75. Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation
76. Aerobic lactate synthesis by rat cardiac muscle
77. Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenase kinase and synergistic inhibition by pyruvate and ADP
78. Inhibition of lactate gluconeogenesis in rat kidney by dichloroacetate
79. Isolation from rat adipocytes of a chemical mediator for insulin activation of pyruvate dehydrogenase
80. Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase
81. Role of pyruvate dehydrogenase and insulin in the regulation of lipogenesis in the lactating mammary gland of the rat during the starved-refed transition
82. Brief treatment with dichloroacetate does not modify suspected subacute necrotizing encephalomyelitis
83. Pyruvate Dehydrogenase Complex Activity in Normal and Deficient Fibroblasts
84. Activation of pyruvate dehydrogenase complex by porcine and biosynthetic human insulin in cultured human fibroblasts
85. Partial pyruvate decarboxylase deficiency with profound lactic acidosis and hyprammonemia: Responses to dichloroacetate and benzoate
86. Lacticacidaemia due to pyruvate dehydrogenase deficiency, with evidence of protein polymorphism in the a-subunit of the enzyme
87. Immunochemical analysis of normal and mutant forms of human pyruvate dehydrogenase
88. Ketone body and acetate formation from oleate by isolated rat testicular cells
89. Metabolic effects of dichloroacetate in diabetic dogs
90. Promotion of carbohydrate oxidation in the heart by some phenylglyoxylic acids
91. The mitochondrial pyruvte carrier. Kinetics and specificity for substrates and inhibitors
92. Substrate regulation of the pyruvate-transporting system in rat liver mitochondria
93. Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier
94. Regulation of pyruvate metabolism in mammalian tissues
95. Phosphorylation-dephosphorylation of enzymes
96. Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle
97. The mammalian pyruvate dehydrogenase complex: Structure and regulation
98. Factors regulating amino release from extrasplanchnic tissues
99. Alanine release by rat hemidiaphragm muscle in vitro
100. The release of alanine by rat diaphragm muscle in vitro
101. The metabolic effects of sodium dichloroacetate in the suckling newborn rat
102. Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate
103. Contribution of the liver and extrasplanchnic tissues to the hypoglycemic action of dichloroacetate in the conscious dog
104. Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro
105. Dichloroacetate—its in vivo effects on carbohydrate metabolism in the conscious dog
106. Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver
107. Effect of dichloroacetate on gluconeogenesis in isolated rat hepatocytes
108. The effects of pyruvate concentration, dichloroacetate and a-cyano-4-hydroxycinnamate on gluconeogenesis, ketogenesis and [3-hydroxybutyrate]/[3-oxybutyrate] ratios in isolated rat hepatocytes
109. Mechanism responsible for the hypoglycemic actions of dichloroacetate and 2-chloropropionate
110. Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells
111. Insulin-like effects of dichloroacetic acid on hexose transport in Swiss 3T3 cells
112. The stimulussecretion coupling of glucose-induced insulin release effect of exogenous pyruvate on islet function
113. Is lactate involved in phenformin-induced insulin secretion?
114. Evidence for a role of exogenous or endogenous hyperlactatemia in insulin secretion in the dog
115. Comparative metabolic effects of acetate and dichloroacetate infusion in the anesthetized dog
116. Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia
117. Effect of DCA on elevated blood lactate levels in biguanide treated diabetes
118. Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans
119. Plasma concentrations and metabolic effects of intravenous sodium dichloracetate
120. Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease
121. Effect of dichloroacetate on plasma lactic acid in exercising dogs
122. Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-d-mannitol
123. Effect of sodium dichloroacetate (DCA) on retinal lactate level in diabetic rat
124. Effect of dichloroacetate sodium on the lactacidemia of experimental endotoxin shock
125. Altered glucose regulation in sepsis revealed by partial reversal of PDH inhibition by dichloroacetate
126. Reversal of phenformin-induced hyperlactaemia by dichloroacetate in normal and diabetic rats
127. Pharmacologie. Reduction par le dichloroacetate de sodium et par l'Insuline des hyperlactatemies Graves consecutives chez le chien anesthisie ou eveille a l'administration de phenformine
128. Dichloroacetate de sodium son application a la therapeutique des hyperlactatemies experimentales
129. Actions du dichloroacetate de sodium associe a l'insuline sur l'hyperlactatemie et l'hyperpyruvicemie provoguees chez le chien par la phenformine
130. Phenformin-induced lactic acidosis: Prevention by dichloroacetate
131. Equilibrii redox e Fosforilativi Delle Vie Centrali Metaboliche: Profolip Epatico in Condizioni Di Controllo, di Trattamento con Dicloroacetato e Con Fenformina Seguita Da Dicloroacetate Nel Ratto
132. Treatment of lactic acidosis with dichloroacetate in dogs
133. The metabolic effects of sodium dichloroacetate in experimental hepatitis in the rat
134. Pharmacological agents and acute experimental hyperlactataemia in the dog
135. Effects of dichloroacetate in the treatment of hypoxic lactic acidosis in dogs
136. Therapeutic benefit of dichloroacetate in experimentally induced hypoxic lactic acidosis
137. Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs
138. Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia
139. Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia
140. Improvement of lactic acidosis from intestinal ischemia using dichloroacetate
141. The genetic heterogenicity of lactic acidosis: Occurrence of recognizable inborn errors of metabolism in a pediatric population with lactic acidosis
142. Inborn errors of pyruvate metabolism
143. Congenital lactic acidosis
144. Dichloroacetate as treatment for congenital lactic acidosis
145. Long term use of low doses of dichloroacetate in a child with congenital lactic acidosis
146. Lactic acidosis due to pyruvate carboxylase deficiency
147. Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: The effects of dichloroacetate (DCA)
148. Case report. Dichloroacetate in the treatment of congenital lactic acidosis
149. Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate
150. The use of dichloroacetate (DCA) in the treatment of lactic acidaemia. Report of two cases
151. Treatment of lactic acidosis: Effects of dichloroacetate on lactate and pyruvate levels in the cerebral spinal fluid
152. Renal effects of dichloroacetate in vivo
153. Clinical and biochemical approach to mitochondrial cytopathy—pyruvate dehydrogenase complex deficiency
154. Dichloroacetate in the treatment of lactic acidosis
155. Detection of Pyruvate Metabolism Disorders by Culture of Skin Fibroblasts with Dichloroacetate
156. Dichloroacetate in biguanide-induced lacticacidosis
157. Treatment of biguanide-induced lactic acidosis with dichloroacetate
158. Treatment of severe lactic acidosis with dichloroacetate
159. Treatment of lactic acidosis with dichloroacetate
160. Phenformin-associated lactic acidosis: Pathogenesis and treatment
161. Lactate homeostasis and lactic acidosis
162. Treatment of lactic acidosis
163. Lactic acidosis: Current concepts
164. Lactic acidosis: The case against bicarbonate therapy
165. The design of a randomized, multicenter study of sodium dichloroacetate (DCA) as a treatment for lactic acidosis
166. Effect of vitamin B-15 on hepatic necrosis produced by CC1-4
167. Effects of diisopropylammonium dichloroethanoate on the histological biochemical changes in the initial stages of carbon tetrachloride poisoning
168. Effects of diisopropylammonium dichloroacetate (DIPA or IS-401) on the histological and biohumoral alterations in the initial phases of carbon tetrachloride intoxication
169. Study of the effect of diisopropylammonium dichloroacetate in comparison with other hepatoprotectors in the Wistar rat intoxicated with carbon tetrachloride
170. Synthesis of diisopropylammonium dichloroacetate and a study of its pharmacological properties
171. 15) analog, on some metabolic indices in experimental chronic toxic hepatitis
172. The effect of pangamic acid on fatty liver in experimental alcohol intoxication
173. Effect of diisopropylammonium dichloroacetate on the pathochemical changes in experimentally induced heliotrin hepatitis
174. Diisopropylammonium dichloroacetate in psychiatric therapy
175. [Action of diisopropylammonium dichloroacetate (DIEDI) on the absorption and utilization of protein hydrolysates].
176. Clinio-metabolic observation during treatment with di-isopropylammonium dichloroetanoate in patients with cirrhosis of the liver
177. Clinico-metabolic survey of the treatment of hepatic cirrhosis with diisopropylammonium dichloroacetate
178. Treatment of acute hepatitus with DADA
179. Effects of the diisopropylammonium dichloroacetate (DIDA) treatment in chronical hepatopathies
180. Trattamento delle Manifestazioni Neuropsichiche da Alcoolismo Cronico Con Dicloroetanoato di Diisopropilammonio
181. The action of diisopropylammonium dichloroethanoate on the hepatic circle
182. About 30 cases of medium hepatic insufficiency treated with the combination of diisopropylammonium dichloroethanoate, antitoxic hepatic extract and B complex
183. Inhibition of medium and short-chain fatty acid oxidation in rat heart mitochondria by dichloroacetate
184. Effects of dichloroacetate on myocardial substrate extraction, epicardial ST-segment elevation, and ventricular blood flow following coronary occlusion in dogs
185. Dichloroacetate: Direct Inhibitor of Lipolysis in the Conscious Dog
186. Metabolic effects of dichloroacetate
187. Effects of dichloroacetate on fatty acid synthesis in interscapular brown adipose tissue of the rat in vivo and in vitro
188. Effects of dichloroacetate on lipid metabolism in isolated rat liver cells
189. Regulation of rat liver hydroxymethylglutaryl coenzyme a reductase by a new class of noncompetitive inhibitors
190. Effects of oxalate and dichloroacetate on lipogenesis and ketongenesis in rat hepatocytes
191. Comparison of the effects of 2-chloropropionate and dichloroacetate on ketogenesis and lipogenesis in isolated rat hepatocytes
192. Stimulation of malic enzyme formation in hepatocyte culture by metabolites: Evidence favoring a nonglycolytic metabolite as the proximate induction signal
193. Effect of dichloroacetate acid on rat hepatic messenger RNA activity profiles
194. Kinetic and magnetic resonance studies of the interaction of oxalate with pyruvate kinase
195. The effect of sodium dichloroacetate (DCA) on plasma triglycerides of streptozotocin diabetic rats
196. Short-term influences of dichloroacetate on genetically hyperlipemic rats
197. Long-term Dichloroacetate Administration to Genetically Hyperlipemic Rats
198. Hypolipidemia and peroxisome proliferation induced by phenoxyacetic acid herbicides in rats
199. The role of platelets in haemostasis and thrombosis
200. Reduction of serum cholesterol in two patients with homozygous familial hypercholesterolemia by dichloroacetate
201. A receptor mediated pathway for cholesterol homeostasis
202. Effects of dichloroacetate and glycoxylate on low density liprotein uptake and growth of cultured fibroblasts
203. Regulation of HMG CoA reductase
204. Measurement of human leukocyte microsomal HMG-CoA reductase activity
205. In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase, studies in normal subjects
206. Elevated cholesterol and bile acid synthesis in an adult patient with homozygous familial hypercholesterolemia. Reduction by a high glucose diet
207. Lowering cholesterol, 1988. Rationale, mechanisms, means
208. Glycolysis
209. Regulation of the activity of acetyl coenzyme A carboxylase by palmitoylcoenzyme A and citrate
210. Effects of dichloroacetate on the lactate/ pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells
211. Amino acid oxidation and alanine production in rat hemidiaphragm in vitro
212. Differential effect of dichloroacetate on branched-chain amino acid catabolism in perfused rat hind limbs
213. Studies on the regulation of leucine catabolism: III. Effects of dichloroacetate and 2-chloropropionate on leucine oxidation by the heart
214. Branched-chain amino acid oxidation by isolated rat tissue preparation
215. Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain a-ketacid dehydrogenase kinase in vitro and in perfused rat heart
216. Reversible ATP-induced inactivation of branched-chain 2-oxo acid dehydrogenase
217. Some aspects of the regulation of fuel supply in omnivorous animals
218. Studies on the regulation leucine catabolism in the liver: Stimulation by pyruvate and dichloroacetate
219. Studies on the regulation of leucine catabolism: II. Mechanism responsible for dichloroacetate stimulation of leucine oxidation
220. Isolation of rabbit liver branched chain a-ketoacid dehydrogenase and regulation by phosphorylation
221. Regulation of the branched-chain 2-oxo acid dehydrogenase complex in hepatocytes isolated from rats fed on a low-protein diet
222. Pharmacological reveral of abnormal glucose regulation, BCAA utilization, and muscle catabolism in sepsis by dichloroacetate
223. Dichloroacetate, lactic acidosis, and the cardiovascular and cellular events associated with shock
224. Effects of dichloroacetate and naloxone on hemodynamic performance and substrate use following endotoxin administration
225. Successful treatment of irreversible hemorrhagic shock in dogs with fructose-1,6 diphosphate and dichloroacetate
226. Effect of dichloroacetate on the exercise performance of patients with heart failure
227. Regulation of glycolysis and pyruvate oxidation in cardiac muscle
228. Comparison of the actions of dichloroacetate and 2-bromopalmitate in palmitateperfused rat hearts: Effects on carboydrate metabolism, contractility and oxygen consumption
229. Regulation of pyruvate dehydrogenase complex in ischemic rat heart
230. Effects of sodium dichloracetate in awake, healthy, Yucatan miniature swine
231. Pharmacologic action of di-isopropyl-ammonium dichloroethanoate
232. The pharmacology of diisopropylamine
233. Pharmacological activities of diisopropylammonium dichloroethanoate (IS 401)
234. Clinical-pharmacological studies of the actions of diisopropylamine dichloroacetate (IS 401)
235. Treatment of angina pectoris with a new compound: DIPA (IS 401)
236. Use of diisopropylammonium dichloroethanoate (DIEDI) in the treatment of chronic arteriosclotic obliterating peripheral arterial disease
237. The clinical use of I.S.-401
238. First results of the treatment of “Raynaud's disease” with diisopropylammonium dichloroacetate
239. Therapeutic effect of diisopropylammonium dichloroacetate in coronaropathies
240. Considerations of the use of diisopropylammonium dichloroacetate in the treatment of arteriosclerotic arteriopathies in the lower limbs
241. Indagini con Somministrazione di Dicloroetanoato di Diisopropilammonio in Corso di Arteriopatia
242. Diisipropylammonium dichloroacetate in the treatment of chronic coronary disease
243. Dicloroetanoato di Diisopropilammonio nelle Vasculopatie Periferiche
244. Dicloroetanoato di Diisopropilammonio Nelle Vasculopatie Periferiche
245. Diisopropylammonium dichloroacetate in combination with oxygen therapy and vasodilators in some ophthalmological cases
246. Dicloroethanoata di Diisopropilammonio in Patologia Cardiovascolare
247. Effectti del Dicloroetanoato di Diisopropilammonio Iniettato Endocarotide in Soggetti Vasculopatici — Relievi Angiografici e Reografici
248. [DIISOPROPYLAMMONIUM DICHLOROETHANOATE (DIEDI). TREATMENT OF PERIPHERAL ARTERIOPATHIES OF OLD AGE].
249. Diisopropylammonium dichloroacetate with emphasis on its ganglioplegic action
250. Diisopropylammonium dichloroacetate (DIPA): Reversible antagonism towards smooth muscle stimulants and inhibition of acetylcholinesterase in the isolated guinea pig ileum
251. Comparative clinical evaluation of the effects of octamethylated pangamic acid and diisopropylammonium dichloroacetate in dermatological pathology
252. Clinical considerations on the use of diisopropylammonium dichloroacetate
253. Relationship between lactate and glutamine metabolism in vitro by the kidney: Differences between dog and rat and importance of alanine synthesis in the dog
254. Renal and systemic acid-base effects of chronic dichloroacetate administration in dogs
255. Effect of chloroacetic acids on the kidney
256. Study of diisopropylammonium dichloroacetate
257. Study of diisopropylammonium dichloroacetate as administered to animals treated with barbiturates
258. [Research on diisopropylammonium dichloroethanate and other similar compounds; their action, alone and in combination with thiopental, on the oxygen consumption of rat brain homogenates].
259. [Research on diisopropylammonium dichloroethanate and other similar compounds; their action on the oxygen consumption of yeast in the absence of and in the presence of glucose].
260. Osteogenetic processes and diisopropylammonium dichloroacetate 3. Interference in the rapidly growing cartilage damage by antimytotic action
261. Transport of metabolic substrates through blood-brain barrier
262. The effect of dichloroacetate on the phosphorylation of mitochondria proteins
263. Pettit FH, Roche TE, Reed LJ: Function of calcium ions in pyruvate dehydrogenase phosphatase activity. Biochem Biophys Res Commun 49:563–571,
264. Effects of dichloroacetate on brain tissue pyruvate dehydrogenase
265. The regulation of pyruvate oxidation during membrane depolarization of rat brain synaptosomes
266. Treatment of lactic acidosis that follows partial cerebral ischemia in the rat
267. The effect of dichloroacetate on brain lactate levels following incomplete ichemia in the hyperglycemic rat
268. Postinsult treatment of ischemia-induced cerebral lactic acidosis in the rat
269. Effects of dichloroacetate in spinal stroke in the rabbit
270. Brain lactate during partial global ischemia and reperfusion: Effect of pretreatment with dichloroacetate in a rat model
271. Effects of dichloroacetate following canine asphyxsial arrest
272. Role of brain acidosis in hypoxic depression of respiration
273. Brain lactic acidosis and ischemic cell damage: Biochemistry and neurophysiology
274. Dichloroacetate treatment of seizure induced cortical and serum hyperlactatemia in rats
275. Effects of dichloroacetate administration during fatal hemorrhagic shock in immature swine
276. Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat
277. Secretion of lactic acid by peritoneal macrophages during extracellular phagocytosis
278. The fine structure of the CNS in multiple sclerosis: II. Vesicular demyelination in an acute case
279. Multiple sclerosis: Distribution of T cell subsets within active chronic lesions
280. Proteinases in inflammatory demyelinating diseases
281. Diisopropylammonium dichloroacetate (DIPA) neuropsychiatry clinical, humoral, and bioelectric contribution in individual cases
282. Diazepam-ethanol interaction in humans: Addition or Potentiation?
283. Hypotension and bradycardia induced by amitriptyline in healthy volunteers
284. Osteogenic processes and diisopropylammonium dichloroethanate
285. Osteogenic processes and diisopropylammonium dichloroethanate: V. Homoplastic graft “take” and bone callus formation
286. Effect of sodium dichloroacetate on denal caries in diabetic rats
287. 14C]alanine into urea in rat hepatocytes
288. The subcellular distribution of rat liver 1-alanine-glyoxylate aminotransferase in relation to a pathway for glucose formation involving glyoxylate
289. Mitochondrial compartmentation of metabolic CO-2 resulting from its site of origin in relation to urea synthesis
290. Study of the mechanism of metabolic activation of chloramphenicol by rat liver microsomes
291. Investigation of the mechanism of the metabolic activation of chloramphenicol by rat liver microsomes. Identification of a new metabolite
292. Metabolism in vitro of enflurane, isoflurane and methoyxflurane
293. Methoxyflurane metabolism and renal dysfunction
294. The metabolic degredation of methoxyflurane in man
295. In vivo nuclear magnetic resonance studies of hepatic methoxyflurance metabolism: II. A reevaluation of hepatic metabolic pathways
296. Residue determination of dichlorvos and related metabolites in animal tissue and fluids
297. Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation
298. The biological fate of vinylidene chloride in rats
299. Cytochrome P-450-dependent metabolism of 1,1,2,2-tetrachloroethane to dichloroacetic acid in vitro
300. Characterization of nonvolatile equeous chlorination products of humic substances
301. Dechloriation mechanisms of chlorinated olefins
302. Pharmacokinetics of sodium dichloroacetate
303. Alternativesubstrate inhibition of l-lactate transport via the monocarboxylate-specific carrier system in human erythrocytes
304. Metabolic pathways in peroxisomes and glyoxysomes
305. Biological disposition of sodium dichloroacetate in animals and humans after intravenous administration
306. Dichloroacetate derivatives. metabolic effects and pharmacodynamics in normal rats
307. Synthesis of Lipophilic Chemotherapeuticals. III.1Remarks on the Properties of Halogen-acylureas, Amides and Related Compounds
308. The acute oral toxicity of acetic, chloracetic, dichloracetic and trichloracetic acids
309. Effect of Acetic, Monochloroacetic, Dichloroacetic, and Trichloroacetic Acids on Oxygen Consumption of Mouse Liver
310. Toxicity of certain halogen substituted aliphatic acids for white mice.
311. Range-finding toxicity data: List IV
312. Variations in toxicity of some halogen derivatives of acetic acid in rats
313. The Toxicity of Some Halogenated Fatty Acids and Their Derivatives
314. In vitro binding of acetic acid and its chlorinated derivatives by the soluble glutathione S-transferases from rat liver
315. The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride
316. Comment on the mutagenic effectiveness of vinyl chloride metabolites
317. Carcinogenicity studies on halogenated hydrocarbons
318. Zur Mutagenitat Von Dichloracetaldehyd und 2,2-dichlor-1,1-dihydroxy-athanphosphonsauremethylester, Moglichen Metaboliten des Phosphororganischen Pestizides Trichlorphon
319. The mutagenicity of dichloracetaldehyde
320. A study of the mutagenicity of anesthetics and their metabolites
321. Short-lived mutagen in salmonella produced by reaction of trichloroacetic acid and dimethyl sulphoxide
322. Toxic effects of chlorinated and brominated alkanoic acids on pseudomonas putida PP3: Selection at high frequencies of mutations in genes encoding dehalogenases
323. Mutagenicity of dichloroacetate (DCA), and ingredient of the “cancer cure” pangamic acid (“vitamin B-15”)
324. Dichloroacetate—a mutagen?
325. Mutagenicity of diisopropylamine dichloracetate, the “active constituent” of vitamin B15 (pangamic acid)
326. Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named “vitamin B-15”)
327. Toxicity of chronic dichloroacetate
328. Dichloroacetate, sodium: 3-month oral toxicity studies in rats and dogs
329. Differential neurotoxicity of dichloracetate and 2,5-hexanedione: Implications for the pathogenesis of gamma diketone neuropathy
330. Comparison of the metabolic and toxic effects of 2-chloropropionate and dichloroacetate
331. Induction of thiamine deficiency by dichloroacetate
332. Lipid class analysis of the central nervous system of myelin-deficient Wistar rats
333. Leucine as an in vitro precursor to lipids in rat sciatic nerve
334. Peripheral neuropathy in oxalosis. A case report with electron microscopic observations
335. Ophthalmic manifestations of primary oxalosis
336. Oxalate retinopathy: An experimental model of a flecked retina