αβ lineage-specific expression of the α T cell receptor gene by nearby silencers

Cell

Volumn 59, Issue 4, 1989, Pages 649-655

  Winoto, Astar ^a,b   Baltimore, David ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; CELL CULTURE; ENHANCER REGION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SILENCER GENE;

ANIMAL; BASE SEQUENCE; CELL LINE; ENHANCER ELEMENTS (GENETICS); GENES, REGULATOR; GENES, STRUCTURAL; HUMAN; MICE; MOLECULAR SEQUENCE DATA; PLASMIDS; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; TRANSFECTION;

EID: 0024445797     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(89)90010-X     Document Type: Article

References (45)

1. Regulation of mating type information in yeast
2. Development of the primary antibody repertoire
3. Characterization of murine thymocytes with CD3-associated T-cell receptor structures
4. Characterization of a “silencer” in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer
5. A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation
6. The γδ T cell receptor
7. Connection between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein
8. Postnatal repression of the α-fetoprotein gene is enhancer independent
9. A new T-cell receptor gene located within the α locus and expressed early in T-cell differentiation
10. Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites
11. The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements
12. T-cell antigen receptor genes and T-cell recognition
13. Identification of sites required for repression of a silent mating type locus in yeast
14. Overlapping positive and negative regulatory domains of the human β-interferon gene
15. The human β-interferon gene enhancer is under negative control
16. The human T cell receptor α-δ locus: a physical map of the variable, joining and constant region genes
17. Rearrangement and expression of T-cell antigen receptor and γ chain genes during thymic differentiation
18. Identification of putative human T cell receptor δ cDNA clones
19. Regulatory elements that modulate expression of human c-myc
20. A FOS protein is present in a complex that binds a negative regulator of MYC
21. Unusual features of the organization and diversity of the T-cell receptor α chain genes
22. RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML
23. Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer
24. Variable region (Vδ) gene segment most frequently utilized in adult thymocytes is 3' of the constant (Cδ) region
25. Rearrangement by inversion of a T-cell receptor δ variable region gene located 3' of the δ constant gene
26. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition
27. Repression mediates cell-type-specific expression of the rat growth hormone gene
28. Identification and sequence of a fourth human T cell receptor chain
29. Activation properties of T cell receptor γδ hybridomas expressing diversity in both γ- and δ-chains
30. Tγ protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer
31. T-cell receptors during thymocyte development
32. The structure, function, and molecular genetics of the γ/δ T cell receptor
33. Developmental regulation of T-cell receptor gene expression
34. Genomic organization of the human T cell receptor α/δ locus
35. A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer
36. Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription
37. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements
38. Expression of T-cell antigen receptor genes during fetal development in the thymus
39. Developmental biology of T cell receptors
40. Genes of the T cell antigen receptor in normal and malignant T cells
41. Two mechanisms for the extinction of gene expression in hybrid cells
42. Separate lineages of T cells expressing the αβ and γδ receptors
43. A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor α locus
44. Genomic organization of the genes encoding the mouse T-cell receptor α chain
45. Organization and sequence of the variable, joining and constant region genes of the human T-cell receptor α chain