Determinants of efficacy and toxicity of aminoglycosides

Journal of Antimicrobial Chemotherapy

Volumn 24, Issue 3, 1989, Pages 281-293

  Mattie, H ^a   Craig, W A ^b   Pechere J C ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHOTERICIN; BENOMYL; CEFTAZIDIME; CISPLATIN; CYCLOSPORIN; DIBEKACIN; DIURETIC AGENT; GENTAMICIN; NAFCILLIN; NETILMICIN; STREPTOMYCIN; TOBRAMYCIN;

ANTIBIOTIC SENSITIVITY; DRUG EFFICACY; HUMAN; INFECTION; MINIMUM INHIBITORY CONCENTRATION; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; PHARMACOKINETICS; PRIORITY JOURNAL; SHORT SURVEY;

ANIMAL; ANTIBIOTICS, AMINOGLYCOSIDE; BACTERIA; BACTERIAL INFECTIONS; HUMAN; SUPPORT, NON-U.S. GOV'T;

EID: 0024441288     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/24.3.281     Document Type: Review

References (72)

1. Aran, J.-M., Dulon, D., Erre, J.-P., Hayashida, T. and Hiel, H. (1988). Evidence that gentamicin acts directly on the hair cells of the cochlea. A physiopathological, immunohistochemical and radioautographic study in the guinea-pig. Journal of Physiology 406, 58P.
2. Aran, J.-M., Erre, J. P., Guilhaume, A. and Aurousseau, C. (1982). The comparative ototoxicities of gentamicin, tobramycin and dibekadn in the guinea pig. A functional and morphological cochlear and vestibular study. Acta Otolaryngologica 390, Suppl., 1-30.
3. Barza, M. and Lauermann, M. (1978). Why monitor serum levels of gentamicin? Clinical Pharmacokinetics 3, 202-15.
4. Black, R. E., Lau, W. K., Weinstein, R. J., Young, L. S. and Hewitt, W. L. (1976). Ototoxicity of amikacin. Antimicrobial Agents and Chemotherapy 9, 956-61.
5. Blaser, J., Stone, B. B., Groner, M. C. and Zinner, S. H. (1985). Impact of netilmicin regimens on the activities of ceftazidime-netilmicin combinations against Pseudomonas aeruginosa in an in vitro pharmacokinetic model. Antimicrobial Agents and Chemotherapy 28, 64-8.
6. Blaser, J., Stone, B. B., Groner, M. C. and Zinner, S. H. (1987). Comparative study with enoxadn and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance. Antimicrobial Agents and Chemotherapy 31, 1054-60.
7. Blaser, J., Stone, B. B. and Zinner, S. H. (1985). Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment in vitro model. Antimicrobial Agents and Chemotherapy 27, 343-9.
8. Brownell, W. E., Bader, C. R., Bertrand, D. and de Ribaupierre, Y. (1985). Evoked mechanical responses of isolated cochlear outer hair cells. Science 227, 194-6.
9. Brummett, R. E. and Fox, K. E. (1982). Studies of aminoglycoside ototoxicity in animal models. In The Aminoglycosides. Microbiology, Clinical use and Toxicology (Whelton, A. and Neu, H. C., Eds), 419-51. Marcel Dekker, New York.
10. Collier, V. U., Lietman, P. S. and Mitch, W. E. (1979). Evidence for luminal uptake of gentamicin in the perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics 210, 247-51.
11. Craig, W. A. and Gudmundsson, S. (1986). The postantibiotic effect. In Antibiotics in Laboratory Medicine, 2nd edn (Lorian, V., Ed.), 515-36. Williams and Wilkins, Baltimore, MD.
12. Davis, R. R., Brummett, R. E., Bendrick, T. W. and Himes, D. L. (1984). Dissociation of maximum concentration of kanamydn in plasma and perilymph from ototoxic effect. Journal of Antimicrobial Chemotherapy 14, 291-302.
13. De Broc, M. E. (1985). Prevention of aminoglycoside nephrotoxirity. In Proceedings of the European Dialysis and Transplant Association, Vol. 22 (Davison, A. M., Ed.), 959-73. Baillière Tindall, London.
14. De Broe, M. E., Paulus, G. J., Verpooten, G. A. Giuliano, R. A., Roels, F. and Tulkens, P. M., Early toxidty of aminoglycosides in human kidney: a prospective, comparative study of amikacin, gentamicin, netilmirin and tobramydn. In Proceedings of the 13th International Congress of Chemotherapy, Vienna, 1983, Vol. 9 (Spitzy, K. H. and Karrer, K., Eds), SE 8.4/1- 2, 86/11-24. Verlag H. Egermann, Vienna.
15. De Broe, M. E., Paulus, G. J., Verpooten, G. A., Roels, F., Buyssens, N., Wedeen, R. et al. Early effects of gentamicin, tobramycin, and amikacin on the human kidney. Kidney International 25, 643-52.
16. Dreschler, W. A., Van der Hulst, R. J. A. M., Tange, R. A. and Urbanus, N. A. M. (1985). The role of high-frequency audiometry in the early detection of ototoxidty. Audiology 24, 38795.
17. Dulon, D., Aran, J.-M., Zajic, G. and Schacht, J. (1986). Comparative uptake of gentamicin, netilmidn, and amikadn in the guinea pig cochlea and vestibule. Antimicrobial Agents and Chemotherapy 30, 96-100.
18. Dulon, D., Aurousseau, G, Erre, J.-P. and Aran, J.-M. (1988a). Relationship between the nephrotoxidty and ototoxidty induced by gentamidn in the guinea pig. Acta Otolaryngologica 106, 219-25.
19. Dulon, D., Hayashida, T., Hiel, H., Erre, J. P. and Aran, J. M. (1988b). Uptake of gentamidn and modifications to function of the sensory cochlear hair cells in vitro and in vivo. In vitro methods of pharmaco-toxicology, Paris 3-4 March 1988. Cytotechnology, Suppl. (June), 39.
20. Feld, R., Rachlis, A., Tuffnell, P. G., Duncan, I., Moran, L., Pinfold, P. et al. (1984). Empiric therapy for infections in patients with granulocytopenia. Continuous v interrupted infusion of tobramycin plus cefamandole. Archives of Internal Medicine 144, 1005-10.
21. Feld, R., Valdivieso, M., Bodey, G. P. and Rodriguez, V. (1977). A comparative trial of sisomidn therapy by intermittent versus continuous infusion. American Journal of the Medical Sciences 214, 179-88.
22. Flueckiger, U., Feller, C. and Gerber, A. U. (1986). Dose-response curves in a man-adapted model: a novel view of comparative in vivo assessment of antibiotics. In Program and Abstracts of the Twenty-Sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, LA 1986. Abstract 577, p. 202. American Sodety for Microbiology, Washington, DC.
23. Frame, P. T., Phair, J. P., Watanakunakorn, C. and Bannister, T. W. P. (1977). Pharmacologic factors associated with gentamidn nephrotoxidty in rabbits. Journal of Infectious Diseases 135, 952-6.
24. Gerber, A. U., Brugger, H.-P., Feller, C, Stritzko, T. and Stalder, B. (1986). Antibiotic therapy of infections due to Pseudomonas aeruginosa in normal and granulocytopenic mice: comparison of murine and human pharmacokinetics. Journal of Infectious Diseases 153, 90-7.
25. Gerber, A. U., Craig, W. A., Brugger, H.-P., Feller, C, Vastola, A. P. and Brandei, J. (1983). Impact of dosing intervals on activity of gentamidn and ticardllin against Pseudomonas aeruginosa in granulocytopenic mice. Journal of Infectious Diseases 147, 910-7.
26. Gerber, A. U., Vastola, A. P., Brandel, J. and Craig, W. A. (1982). Selection of aminoglycoside- resistant variants of Pseudomonas aeruginosa in an in vivo model. Journal of Infectious Diseases 146, 691-7.
27. Giuliano, R. A., Paulus, G. J., Verpooten, G. A., Pattyn, V. M., Pollet, D. E., Nouwen, E. J. et al. (1984). Recovery of cortical phospholipidosis and necrosis after acute gentamidn loading in rats. Kidney International 26, 838-47.
28. Giuliano, R. A., Verpooten, G. A., Verbist, L., Wedeen, R. P. and De Broe, M. E. (1986). In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats. Journal of Pharmacology and Experimental Therapeutics 236, 470-5.
29. Gudmundsson, S., Tumidge, J. and Craig, W. A. (1982). Effect of different dosage regimens on in vivo efficacy of antibiotics against Klebsiella pneumoniae. Clinical Research 30, 777A.
30. Hayashida, T., Nomura, Y., Iwamori, M., Nagai, Y. and Kurata, T. (1985). Distribution of gentamicin by immunofluorescence in the guinea pig inner ear. Archives of Otorhinolaryngology 242, 257-64.
31. Jacobson, E. J., Downs M. P. and Fletcher, J. L. (1969). Clinical findings in high-frequency thresholds during ototoxic drug usage. Journal of Auditory Research 9, 379-85.
32. Kaloyanides, G. J. and Pastoriza-Munoz, E. (1980). Aminoglycoside nephrotoxicity. Kidney International 18, 571-82.
33. Kapusnik, J. E., Hackbarth, C. J., Chambers, H. F., Carpenter, T. and Sande, M. A. (1988). Single, large, daily dosing versus intermittent dosing of tobramycin for treating experimental pseudomonas pneumonia. Journal of Infectious Diseases 158, 7-12.
34. Kapusnik, J. E. and Sande, M. A. (1986). Novel approaches for the use of aminoglycosides: the value of experimental models. Journal of Antimicrobial Chemotherapy 17, Suppl. A, 7-10.
35. Klastersky, J., Meunier-Carpentier, F. and Prevost, J.-M. (1977). Significance of antimicrobial synergism for the outcome of gram negative sepsis. American Journal of the Medical Sciences 273, 157-67.
36. Kozak, S., Gerber, A. U., Greter, U., Feller, C. and Bangerter, T. (1985). Once daily vs. TID- dosing of netilmicin in combination therapy of P. aeruginosa in granulocytopenic mice. 14th International Congress of Chemotherapy, Kyoto. Abstract S-85-8.
37. Laurent, G., Carlier, M. B., Rollman, B., Van Hoof, F. and Tulkens, P. (1982). Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies witlr gentamicin and amikacin. Biochemical Pharmacology 31, 3861-70.
38. Lietman, P. S. (1985). Aminoglycosides and spectinomydn: aminocyditols. In Principles and Practice of Infectious Diseases, 2nd edn (Mandel, G. L., Douglas, R. G. and Bennett, J. E., Eds), 192-206. John Wiley, New York.
39. Line, D. H., Poole, G. W. and Waterworth, P. M. (1970). Serum streptomyrin levels and dizziness. Tubercle SI, 76-81.
40. MacArthur, R. D., Lol ans, V., Zar, F. A. and Jackson, G. G. (1984). Biphasic, concentration- dependent and rate-limited, concentration-independent bacterial killing by an aminoglycoside antibiotic. Journal of Infectious Diseases 150, 778-9.
41. Moore, R. D., Smith, C. R. and Lietman, P. S. (1984). The assodation of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia. Journal of Infectious Diseases 149, 443-8.
42. Moore, R. D., Lietman, P. S. and Smith, C. R. (1987). Ginical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. Journal of Infectious Diseases 155, 93-9.
43. Mordenti, J. J., Quintiliani, R. and Nightingale, C. H. (1985). Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model. Journal of Antimicrobial Chemotherapy 15, Suppl. A, 313-21.
44. Noone, P., Parsons, T. M. C., Pattison, J. R., Slack, R. C. B., Garfield-Davies, D. and Hughes, K. (1974). Experience in monitoring gentamidn therapy during treatment of serious gramnegative sepsis. British Medical Journal 1, 477-81.
45. Nordstrom, L., Banck, G., Beifrage, S., Juhlin, I., Tjemström, ö. and Toremalm, N. G. (1973). Prospective study of the ototoxidty of gentamidn. Acta Pathologica et Microbiologica Scandinavica. Section B 81, Suppl. 241, 58-61.
46. Nordström, L., Cronberg, S., Ringberg, H., Tjemström, Ö. and Wälder, M. (1985). Prospective, comparative, randomized clinical study of aminoglycosides given once a day versus three times a day in severe infections. In Recent Advances in Chemotherapy, Antimicrobial Section 3. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, 1985 (Ishigami, J., Ed.), 2653-4. University of Tokyo Press, Tokyo.
47. Pattyn, V. M., Verpooten, G. A., Giuliano, R. A. Zheng, F. and De Broe, M. E. (1988). Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamidn in the kidney cortex of rats. Journal of Pharmacology and Experimental Therapeutics 244, 694-8.
48. Pechère, J. C. and Bernard, P. A. (1982). Survrillance des traitements par aminosides au moyen des potentiels évoqués du tronc cérébral. In Nephrotoxiciti Ototoxicité Médicamenteuses (Fillastre, J. P., Ed.), 345-57. Edition INSERM, Rouen, France.
49. Pechère, J. C. and Bernard, P. A. (1984). Gentamicin ototoxicity can be avoided if a new therapeutic regimen is used. An experimental animal model. In Program and Abstracts of the Twenty-Fourth Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, 1984. Abstract 484, p. 178. American Society for Microbiology, Washington, DC.
50. Pechère, M., Letarte, R., and Pechère, J.-C. (1987). Efficacy of different dosing schedules of tobramycin for treating a murine Klebsiella pneumoniae bronchopneumonia. Jotanal of Antimicrobial Chemotherapy 19, 487-91.
51. Pechère, J. C., Marchou, B., Michéa-Hamzehpour, M. and Auckenthaler, R. (1986). Emergence of resistance after therapy with antibiotics used alone or combined in a murine model. Journal of Antimicrobial Chemotherapy 17, Suppl. A, 11-8.
52. Powell, S. H., Thompson, W. L., Luthe, M. A., Stem, R. C., Grossnilclaus, D. A., Bloxham, D. et al. (1983). Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin. Journal of Infectious Diseases 147, 918-32.
53. Reiner, N. E., Bloxham, D. D. and Thompson, W. L. (1978). Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs. Journal of Antimicrobial Chemotherapy 4, Suppl. A. 85-101.
54. Relier, L. B., Schoenknecht, F. D., Kenny, M. A. and Sherris, J. C. (1974). Antibiotic susceptibility testing of Pseudomonas aeruginosa: selection of a control strain and criteria for magnesium and calcium content in media. Journal of Infectious Diseases 130, 454-63.
55. Sculier, J. P. and Klastersky, J. (1984). Significance of serum bactericidal activity in gram-negative bacillary bacteremia in patients with and without granulocytopenia. American Journal of Medicine 76, 429-35.
56. Shah, P. M., Junghanns, W. and Stille, W. (1976). Dosis-Wirkungs-Beziehung der Bakterizidie beicoli, K. pneumoniae und Staphylococcus aureus. Deutsche Medizinische Wochenschrift 101, 325-8.
57. Silverblatt, F. J. and Kuehn, C. (1979). Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney International 15, 335-45.
58. Stratton, C. W. and Relier, L. B. (1977). Serum dilution test for bactericidal activity I. Selection of a physiologic diluent. Journal of Infectious Diseases 136, 187-95.
59. Tange, R. A., Conijn, E. A., Van Zeijl, L. G. and Huizing, E. H. (1982). Pattem of gentamicin- induced cochlear degeneration in the guinea pig. A morphological and electro-physiological study. Archives of Otorhinolaryngology 236, 173-84.
60. Tange, R. A., Dreschler, W. A. and Van der Hulst, R. J. A. M. (1985). The importance of hightone audiometry in monitoring for ototoxicity. Archives of Otorhinolaryngology 242, 77-81.
61. Thrupp, L. D. (1986). Susceptibility testing of antibiotics in liquid media. In Antibiotics in Laboratory Medicine, 2nd edn (Lorian, V., Ed.), 93-150. Williams and Wilkins, Baltimore, MD.
62. Tran Ba Huy, P., Bernard, P. and Schacht, J. (1986). Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs. Journal of Clinical Investigation 77, 1492-500.
63. Tulkens, P. M., De Broe, M. E., Maldague, P. and Heuson-Stiennon, J. A. (1984). Lysosomal alterations in aminoglycoside-induced acute renal failure. In Acute Renal Failure Correlations between Morphology and Function (Solez, K. and Whelton, A., Eds), 299-327. Marcel Dekker, New York.
64. Van der Auwera, P. and Klastersky, J. (1987). Serum bactericidal activity and postantibiotic effect in serum of patients with urinary tract infection receiving high-dose amikacin. Antimicrobial Agents and Chemotherapy 31, 1061-8.
65. Verpooten, G. A., Giuliano, R. A., Pattyn, V. M., Scharpé, S. L. and De Broe, M. E. (1986). Renal cortical uptake kinetics of gentamicin in rats with impaired renal function. American Journal of Kidney Diseases 8, 304-7.
66. Verpooten, G. A., Giuliano, R. A., Verbist, L., Eestermans, G. and De Broe, M. E. (1989). Once- daily dosing decreases renal accumulation of gentamicin and netilmicin. Clinical Pharmacology and Therapeutics 45, 22-7.
67. Vogelman, B. S. and Craig, W. A. (1985). Postantibiotic effects. Journal of Antimicrobial Chemotherapy 15, Suppl. A, 37-46.
68. Vogelman, B. S. and Craig, W. A. (1986). Kinetics of antimicrobial activity. Journal of Pediatrics 108, 835-40.
69. Vogelman, B., Gudmundsson, S., Tumidge, J., Leggett, J. and Craig, W. A. (1988a). In vivo postantibiotic effect in a thigh infection in neutropenic mice. Journal of Infectious Diseases 157, 287-98.
70. Vogelman, B., Gudmundsson, S., Leggett, J., Tumidge, J., Ebert, S. and Craig, W. A. (1988b). Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. Journal of Infectious Diseases 158, 831-47.
71. Whelton, A. (1985). Therapeutic initiatives for the avoidance of aminoglycoside toxicity. Journal of Clinical Pharmacology 25, 67-81.
72. Zenner, H. P., Zimmermann, U. and Schmitt, U. (1985). Reversible contraction of isolated mammalian cochlear hair cells. Hearing Research 18, 127-33.