The effect of prolonged intrauterine hyperinsulinemia on iron utilization in fetal sheep

Pediatric Research

Volumn 26, Issue 5, 1989, Pages 467-469

  Georgieff, Michael K ^a   Widness, John A ^b   Mills, Marla M ^a   Stonestreet, Barbara S ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; INSULIN; IRON;

ANIMAL EXPERIMENT; DIABETES MELLITUS; ERYTHROCYTE LEVEL; FETUS; HEMOGLOBIN SYNTHESIS; HYPERINSULINEMIA; INTRAVENOUS DRUG ADMINISTRATION; IRON BLOOD LEVEL; IRON METABOLISM; MATERNAL DISEASE; NONHUMAN; OXYGEN SATURATION; PREGNANCY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; SHEEP;

ANIMAL; ERYTHROCYTES; FEMALE; FETAL BLOOD; HEMOGLOBINS; HYPERINSULINISM; IRON; MATERNAL-FETAL EXCHANGE; OXYGEN; PREGNANCY; PREGNANCY COMPLICATIONS; SHEEP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0024439411     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/00006450-198911000-00021     Document Type: Article

References (28)

1. Chockalingam UM, Murphy E, Ophoven JC, Weisdorf SA, Georgieff MK 1987 Cord transferrin and ferritin values in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia. J Pediatr 111:283-286
2. Amarnath UM, Ophoven JJ, Mills MM, Murphy EL, Georgieff MK 1989 The relationship between decreased iron stores, serum iron and neonatal hypoglycemia in large-for-dates newborn infants. Acta Paediatr Scand (in press)
3. Georgieff MK, Amarnath UM, Landon MB, Mills MM, Ophoven JJ 1988 Newborn iron status of infants of diabetic mothers (IDMs). Pediatr Res 23:390(abstr)
4. Dallman PR 1986 Biochemical basis for the manifestations of iron deficiency. Ann Rev Nutr 6:13-40
5. Mimouni F, Miodovnik, M, Siddiqi TA, Butler JB, Holdroyde J, Tsang RC 1986 Neonatal polycythemia in infants of insulin-dependent diabetic mothers. Obstet Gynecol 68:370-372
6. Widness JA, Susa JB, Garcia JF, Singer OB, Sehgal P, Oh W, Schwartz R, Schwartz HC 1981 Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesus fetuses. J Clin Invest 67:637-642
7. Philipps AF, Porte PJ, Strabinsky S, Rosenkranz TS, Raye JR 1984 Effects of chronic fetal hyperglycemia upon oxygen consumption in the ovine uterus and conceptus. J Clin Invest 74:279-286
8. Milley JR, Papacostas JS, Tabata BK 1986 Effect of insulin on uptake of metabolic substrates by the fetus. Am J Physiol 231:E349-E359
9. Stonestreet BS, Ogburn PL, Goldstein M, Oh W, Widness JA 1989 Effects of chronic fetal hyperinsulinemia on plasma arachidonic acid and prostaglandin concentrations. Am J Obstet Gynecol (in press)
10. Stonestreet BS, Goldstein M, Oh W, Widness JA 1987 The effects of prolonged hyperinsulinemia on red cell mass in fetal sheep. Pediatr Res 21:378(abstr)
11. Stonestreet BS, Goldstein M, Oh W, Widness JA. Effects of prolonged hyperinsulinemia on erythropoiesis in fetal sheep. Am J Physiol (in press)
12. Hales CN, Randle PH 1963 Immunoassay of insulin with insulin antibody precipitates. Biochem J 88:137-146
13. Brace RA 1983 Blood volume and its measurement in the chronically catheterized sheep fetus. Am J Physiol 244:H487-H494
14. Brace RA 1984 Blood volume in the fetus and methods for its measurement. In: Nathanielsz PW (ed) Animal Models in Fetal Medicine. Perinatology Press, Ithaca, NY, pp 1-36
15. Lister G, Walker TK, Versmold HT, Dallman PR, Rudolph AM 1979 Oxygen delivery in lambs: cardiovascular and hematologic development. Am J Physiol 237:H668-675
16. Carson BS, Philipps AF, Simmons MA, Battaglia FC, Meschia G 1980 Effects of sustained insulin infusion upon glucose uptake and oxygenation of the ovine fetus. Pediatr Res 14:147-152
17. Dainak N, Kreczko S 1985 Interactions of insulin, insulin-like growth factor II and platelet-derived growth factor on erythropoietic culture. J Clin Invest 76:1237-1242
18. Dallman PR 1987 Iron deficiency and related nutritional anemias. In: Nathan DG, Oski FA (eds) Hematology of Infancy and Childhood, 3rd ed. WB Saunders, Philadelphia, pp 301-302
19. Reynafarje C, Lozano R, Valdivieso J 1959 The polycythemia of high altitudes: Iron metabolism and related aspects. Blood 14:433-455
20. Hoskins FH, Hansard SL 1964 Placental transfer and fetal tissue iron utilization in sheep. J Nutrition 83:10-14
21. Teitel D, Sidi D, Bernstein D, Heymann MA, Rudolph AM 1985 Chronic hypoxemia in the newborn lamb: cardiovascular, hematopoietic, and growth adaptations. Pediatr Res 19:1004-1010
22. McPhail AP, Charlston RW, Bothwell TH, Torrance JD 1980 The relationship between maternal and infant iron status. Scand J Haematol 25:141-150
23. Picon-Reategui E, Lozano R, Valdivieso J 1961 Body composition at sea level and high altitudes. J Appl Physiol 16:589-592
24. Miles DS, Bransford DR, Horvath SM 1981 Hypoxia effects on plasma volume shifts at rest, work, and recovery in supine position. J Appl Physiol 51:148-153
25. Yao AC, Lu T, Castellanos R, Matanic BP 1978 Effect of prenatally and postnatally induced hypoxia on blood volume of newborn lambs. Life Sci 22:931-936
26. Woodruff CW, Bridgeforth EB 1953 Relationship between the hemogram of the infant and that of the mother during pregnancy. Pediatrics 12:681-685
27. Oski FA 1979 The nonhematologic manifestations of iron deficiency. Am J Dis Child 133:315-322
28. Lozoff B, Brittenham GM, Wolf AW, McClish DK, Kuhnert PM, Jimenez E, Jimenez J, Mora LA, Gomez I, Krausko PF 1987 Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics 79:981-995