Calphostins (ucn-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities

The Journal of Antibiotics

Volumn 42, Issue 10, 1989, Pages 1470-1474

  Kobayashi, Eiji ^a   Ando, Katsuhiko ^a   Nakano, Hirofumi ^a   Iida, Takao ^a   Tamaoki, Tatsuya ^a   Ohno, Hiroe ^a   Morimoto, Makoto ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALPHOSTIN; CALPHOSTIN C; PROTEIN KINASE C;

ANIMAL CELL; BRAIN; CELL CULTURE; CELL STRAIN MCF 7; CLADOSPORIUM CLADOSPORIOIDES; CYTOTOXICITY; DRUG PURIFICATION; DRUG SCREENING; ENZYME INHIBITION; FUNGUS; HELA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PRIORITY JOURNAL; RAT; STREPTOCOCCUS FAECALIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTIBIOTICS, ANTINEOPLASTIC; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLADOSPORIUM; FERMENTATION; HELA CELLS; POLYCYCLIC HYDROCARBONS; PROTEIN KINASE C;

EID: 0024438833     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.42.1470     Document Type: Article

References (8)

1. Kobayashi, E.; K. Ando, H. Nakano & T. Tamaoki: UCN-1028A, a novel and specific inhibitor of protein kinase C, from Cladosporium. J. Antibiotics 42: 153-155, 1989.
2. Kikkawa, U.; R. Minakuchi, Y. Takai & Y. Nishizuka: Calcium activated, phospholipid-dependent protein kinase (protein kinase C) form rat brain. Methods Enzymol. 99: 288-298, 1983.
3. Kuo, J. F. & P. Greengard: Cyclic nucleotide-dependent protein kinases. IV. Wide spread occurrence of adenosine 3′,5′-monophosphate-dependent protein kinase in various tissue and phyla of animal kingdom. Proc. Natl. Acad. Sci. U.S.A. 64: 1349-1355, 1969.
4. Takai, Y.; S. Nagaya, M. Inoue, A. Kishimoto, K. Nishiyama, H. Yamamura & Y. Nishizuka: Comparison of mode of activation of guanosine 3′,5′-monophosphate-dependent and adenosin 3′,5′-monophosphate-dependent protein kinases from silk worm. J. Biol. Chem. 251: 1481-1487, 1976.
5. Gomi, K.; S. Akinaga, T. Oka & M. Morimoto: Analysis of receptors, cell surface antigens, and proteins in human melanoma cell lines resistant to human recombinant β- orγ-interferon. Cancer Res. 46:6211 - 6216, 1986.
6. Arnone, A.; L. Camarda, G. Nasini & L. Merlini: Secondary mould metabolites. Part 13. Fungal perylenequinones: Phleichrome, isophleichrome, and their endoperoxides. J. Chem. Soc. Perkin Trans. I 1985: 1387-1392, 1985.
7. Iida, T.; E. Kobayashi, M. Yoshida & H. Sano: Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. J. Antibiotics 42: 1475-1481, 1989.
8. Kobayashi, E.; H. Nakano, M. Morimoto & T. Tamaoki: Calphostin C (UCN-1028C), a novel microbial compound, highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159: 548-553, 1989.