(−)‐(S)‐Flunoxaprofen and (−)‐(S)‐naproxen isocyanate: Two new fluorescent chiral derivatizing agents for an enantiospecific determination of primary and secondary amines

Chirality

Volumn 1, Issue 3, 1989, Pages 223-234

  Martin, E ^a   Quinke, K ^a   Spahn, H ^a   Mutschler, E ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

antiarrhythmics; diastereoisomeric ureas; enantiomers; fluorophores; high performance liquid chromatography (HPLC); inversion of optical rotation; plasma; propranolol

Indexed keywords

CIBENZOLINE; DIPRAFENONE; FLECAINIDE; FLUNOXAPROFEN ISOCYANATE; METOPROLOL; MEXILETINE; NAPROXEN ISOCYANATE; PRENYLAMINE; PROPAFENONE; PROPRANOLOL; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

BLOOD LEVEL; DRUG ISOLATION; DRUG MIXTURE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; METHODOLOGY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION;

AMINES; BENZOXAZOLES; CHEMISTRY; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORESCENT DYES; HUMAN; INDICATORS AND REAGENTS; NAPROXEN; OPTICAL ROTATION; SPECTROMETRY, FLUORESCENCE; SPECTRUM ANALYSIS, MASS; STEREOISOMERISM;

EID: 0024438798     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.530010308     Document Type: Article

References (22)

1. Proposal for the classification of high‐performance liquid chromatographic chiral stationary phases: How to choose the right column
2. Enantiomeric resolution of drug compounds by liquid chromatography
3. Separation of enantiomers in ion‐pair chromatographic systems
4. Separation of amino acid enantiomers and chiral amines using precolumn derivatization with 1‐(9‐fluorenyl)ethyl chloroformate and reversed phase liquid chromatography
5. Determination of the enantiomeric composition of chiral aminoalcohols using chiral derivatization and reversed‐phase liquid chromatography
6. High performance liquid chromatographic resolution of enantiomers of 1‐phenyl‐2‐aminopropanes (amphetamines) with four chiral reagents
7. Simultaneous determination of R‐ and S‐prenylamine in plasma and urine by reversed‐phase liquid chromatography
8. Optical resolution of β‐blocking agents by thin‐layer chromatography and high performance liquid chromatography as diastereomeric R‐(‐)‐1‐(1‐naphthyl)ethylureas
9. Determination of metoprolol enantiomers in plasma and urine using S‐(‐)‐phenylethyl isocyanate as a chiral reagent
10. Rapid determination of the enantiomers of metoprolol, oxprenolol and propranolol in urine
11. Activated (+)‐naproxen as derivatization reagent for the enantioselective determination of chiral amines and alcohols (abstract)
12. Enantiospecific high‐performance liquid chromatographic (HPLC) determination of baclofen and its fluoro analogue in biological material
13. S‐(+)‐Naproxen chloride as acylating agent for separating the enantiomers of chiral amines and alcohols
14. S‐flunoxaprofen chloride as a chiral derivatization reagent
15. Activated α‐alkyl‐α‐arylacetic acid enantiomers for stereoselective thinlayer chromatographic and high performance liquid chromatographic determination of chiral amines
16. Simultaneous determination of d‐and l‐propranolol in human plasma by high performance liquid chromatography
17. Separation of the enantiomers of 3,5‐dinitrophenyl carbamates and 3,5‐dinitrophenyl ureas
18. Structural and environmental factors in fluorescence