Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase

Biochemical and Biophysical Research Communications

Volumn 164, Issue 2, 1989, Pages 678-685

  Mayer, Bernd ^a   Schmidt, Kurt ^b   Humbert, Peter ^a   Böhme, Eycke ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ENDOTHELIUM DERIVED RELAXING FACTOR; GUANYLATE CYCLASE;

ANIMAL CELL; AORTA; ENDOTHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; RELAXING FACTOR; SWINE;

ANIMAL; AORTA; ARGININE; CALCIUM; CATTLE; CELLS, CULTURED; CYTOSOL; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GUANYLATE CYCLASE; KINETICS; LUNG; NITRIC OXIDE; SUPPORT, NON-U.S. GOV'T; SWINE;

EID: 0024427710     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/0006-291X(89)91513-1     Document Type: Article

References (26)

1. Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries
2. Ca2+-dependent formation of an L-arginine-derived activator of soluble guanylyl cyclase in bovine lung.
3. Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells
4. Effects of bradykinin and angiotensin II on intracellular Ca2+ dynamics in endothelial cells.
5. Proximal and distal dog coronary arteries respond differently to basal EDRF but not to NO.
6. Release of NO and EDRF from cultured bovine aortic endothelial cells.