Conformational Analysis and Molecular Modeling of 1-Phenyl-, 4-Phenyl-, and l-Benzyl-l,2,3,4-tetrahydroisoquinolines as D1Dopamine Receptor Ligands

Journal of Medicinal Chemistry

Volumn 32, Issue 9, 1989, Pages 2050-2058

  Charifson, Paul S ^a   Bowen, J Phillip ^a   Wyrick, Steven D ^a   Hoffman, Andrew J ^a   Cory, Michael ^b   McPhail, Andrew T ^c   Mailman, Richard B ^d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Burroughs Wellcome Co   (United States)

^c DUKE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 6 CHLORO 1,2,3,4 TETRAHYDRO 2 METHYL 7 ISOQUINOLINOL; 6 CHLORO 1,2,3,4 TETRAHYDRO 1 PHENYL 2 PROPYL 7 ISOQUINOLINOL; 6 CHLORO 1,2,3,4 TETRAHYDRO 2 METHYL 1 PHENYL 7 ISOQUINOLINOL; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR; UNCLASSIFIED DRUG;

DRUG RECEPTOR BINDING; DRUG STRUCTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY; X RAY ANALYSIS;

BENZAZEPINES; CHEMISTRY; COMPUTER SIMULATION; DOPAMINE ANTAGONISTS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D1; SCH-23390; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; X-RAY DIFFRACTION;

EID: 0024425450     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00129a006     Document Type: Article

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