Synthesis, structure and inhibitory effects on cyclooxygenase, lipoxygenase, thromboxane synthetase and platelet aggregation of 3-amino-4,5-dihydro-1H-pyrazole derivatives

European Journal of Medicinal Chemistry

Volumn 24, Issue 4, 1989, Pages 435-445

  Frigola, Jordi ^a   Colombo, Augusto ^a   Pares, Juan ^a   Martinez, Luis ^a   Sagarra, Rosa ^a   Roser, Roberto ^a  

^a Laboratorios Dr Esteve SA   (Spain)

Author keywords

15 lipoxygenase inhibitors; 4,5 dihydro 1H pyrazole derivatives; 13C NMR spectroscopy; cyclooxygenase inhibitors; platelet aggregation inhibitors; pyrazole derivatives; thromboxane synthetase inhibitors

Indexed keywords

2 PYRAZOLINE 3 AMINE DERIVATIVE; 4,5 DIHYDRO 3 (1 PYRROLYL) 1 (3 TRIFLUOROMETHYLPHENYL) 1H PYRAZOLE; ACETYLSALICYLIC ACID; ARACHIDONATE 15 LIPOXYGENASE; NORDIHYDROGUAIARETIC ACID; PHENYLBUTAZONE; PROSTAGLANDIN SYNTHASE; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; CATTLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RABBIT; THROMBOCYTE AGGREGATION;

EID: 0024420643     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/0223-5234(89)90089-5     Document Type: Article

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