Altered Function of Protein Kinase C and Cyclic Adenosine Monophosphate-dependent Protein Kinase in a Cell Line Derived from a Mouse Lung Papillary Tumor

Cancer Research

Volumn 49, Issue 18, 1989, Pages 5191-5198

  Nicks, Kendal M ^a   Droms, Kurt A ^a   Malkinson, Alvin M ^a   Fossli, Tellef ^b   Smith, Garry J ^c  

^a UNIVERSITY OF COLORADO   (United States)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PHORBOL ESTER; PROTEIN KINASE C; RADIOISOTOPE;

ANIMAL CELL; CELL CULTURE; GENE EXPRESSION; LUNG TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULTRASTRUCTURE;

ANIMAL; BLOTTING, WESTERN; CARCINOMA, PAPILLARY; CELL DIVISION; CELL LINE; CYCLIC AMP; KINETICS; LUNG NEOPLASMS; MICE; MICROSCOPY, ELECTRON, SCANNING; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024418480     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Sweet, R. W., Yokoyama, S., Kamata, T., Feramisco, J. R., Rosenberg, M., and Gross, M. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity. Nature (Lond.), 311:273–275, 1984.
2. Wolfman, A., and Macara, I. G. Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts. Nature (Lond.), 325:359–361, 1987.
3. Gilmore, T., Declue, J. R., and Martin, G. F. Protein phosphorylation at tyrosine is induced by the \-erb β gene produced in vivo and in vitro. Cell, 40:609–618, 1985.
4. Kamata, T., Sullivan, N. F., and Wooten, M. W. Reduced protein kinase C activity in a ras-resistant cell line derived from Ki-MSV transformed cells. Oncogene, 7:37–46, 1987.
5. Weyman, C. M., Taparowsky, E. J., Wolfson, M., and Ashendel, C. L. Partial down-regulation of protein kinase C in C3H/10T1/2 mouse fibroblasts transfected with the human Ha-ras oncogene. Cancer Res., 48:6535–6541, 1988.
6. Hickie, R. A., Jan, S-H., and Datta, A. Comparative adenylate cyclase-activities in homogenate and plasma membrane fractions of Morris hepatoma 5123tc(h). Cancer Res., 35:596–600, 1975.
7. Majumder, G. C. Protein kinase activity in mouse mammary carcinoma. Biochem. Biophys. Res. Commun., 74:1140–1145, 1977.
8. Droms, K. A., Haley, B. E., and Malkinson, A. M. Decreased incorporation of the photoaffinity probe 8-N3-[γ-32PJGTP into a 45kD protein in lung tumors. Biochem. Biophys. Res. Commun., J44:591–597, 1987.
9. Malkinson, A. M., and Butley, M. S. Alterations in cyclic adenosine 3′, 5′-monophosphate-dependent protein kinases during normal and neoplastic lung development. Cancer Res., 41:1334–1341, 1981.
10. Butley, M. S., Beer, D. G., and Malkinson, A. M. Functional changes in the regulatory subunit of the type II cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase isozyme during normal and neoplastic lung development. Cancer Res., 44:2689–2697, 1984.
11. Butley, M. S., Stoner, G. D., Beer, D. G., Beer, D. S., Mason, R. J., and Malkinson, A. M. Changes in cyclic adenosine 3′, 5′-monophosphate-dependent protein kinases during the progression of mouse lung tumors. Cancer Res., 45:3677–3689, 1985.
12. Smith, G. J., LeMesurier, S. M., De Montfort, M. L., and Lykke, A. W. J. Development and characterization of type 2 pneumocyte-related cell lines from normal adult mouse lung. Pathology, 16:401–405, 1984.
13. Steele, J. G., Savolainen, T. A., and Smith, G. J. Expression of fibronectin in clonally related transformed and control sublines from an epithelial cell strain and a tumor line of mouse alveolus. Cancer Res., 48:4933–4940, 1988.
14. Kennel, S. J., Foote, L. J., and Flynn, K. M. Tumor antigen on benign adenomas and on murine lung carcinomas quantitated by a two-site monoclonal assay. Cancer Res., 46:707–712, 1986.
15. Smith, G. J., and Lykke, A. W. J. Characterization of a neoplastic epithelial cell strain derived by dexamethasone treatment of cultured normal mouse type 2 pneumocytes. J. Pathol., 147:165–172, 1985.
16. Nation, J. L. A new method using hexamethyldisilazane for preparation of soft insect tissue for scanning electron microscopy. Stain Technol., 58:347–351, 1983.
17. Lamoreaux, W. Prevention of outgasssing when coating tissues dried with hexamethyldisilazane. Electron Microscop. Bull., 18:91, 1988.
18. Greene, L. A., and Rein, G. Release, storage and uptake of catecholamine by a clonal cell line of nerve growth factor (NGF) responsive pheochromocytoma cells. Brain Res., 129:247–263, 1977.
19. Laemmli, U. K. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature (Lond.), 227:680–685, 1970.
20. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193:265–275, 1951.
21. Malkinson, A. M., Beer, D. S., Sadler, A. J., and CofTman, D. S. Decrease in the protein kinase C-catalyzed phosphorylation of an endogenous lung protein (A/r 36, 000) following treatment of mice with the tumor-modulatory agent butylated hydroxytoluene. Cancer Res., 45:5751–5756, 1985.
22. Malkinson, A. M., Conway, K., Bartlett, S., Butley, M. S., and Conroy, C. Strain differences among inbred mice in protein kinase C activity. Biochem. Biophys. Res. Commun., 122:492–498, 1984.
23. Roskoski, R., Jr. Assays of protein kinases. Methods Enzymol., 99:3–6, 1983.
24. Oyen, O., Froysa, A., Sandberg, M., Eskild, N., Josef, D., Hansson, V., and Jahnsen, T. Cellular localization and age-dependent changes in mRNA for cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase in rat testis. Biol. Repro., 37:947–956, 1987.
25. Clegg, C. H., Cadd, G. G., and McKnight, G. S. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 85:3703–3707, 1988.
26. Seamon, K. B., and Daly, J. W. Forskolin:a unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucleotide Res., 7:201–225, 1981.
27. Tamaoki, T., Nomoto, H., Takahashi, I., Kato, Y., Morimoto, M., and Tomita, F. Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinase. Biochem. Biophys. Res. Commun., 755:397–402, 1988.
28. Pomerantz, A. H., Rudolph, S. A., and Greengard, P. Photoaffinity labeling of a protein kinase from bovine brain with 8-azidoadenosine-3′, 5′-monophosphate. Biochemistry, 14:3858–3862, 1975.
29. Diamond, L., O’Brien, T. G., and Baird, W. M. Tumor promoters and the mechanisms of tumor promotion. Adv. Cancer Res., 32:1–75, 1980.
30. Gescher, A. Antiproliferative properties of phorbol ester tumor promotion. Biochem. Pharmacol., 24:2587–2592, 1985.
31. Keski-Oja, J., Loef, E. B., Lyons, R. M., Coffed, R. J., Jr., and Moses, H. L. Transforming growth factors and control of neoplastic cell growth. J. Cell. Biochem., 33:95–107, 1987.
32. Frater-Schroder, M., Risau, W., Hallmann, R., Gautschi, P., and Bohlen, P. Tumor necrosis factor type a, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc. Natl. Acad. Sci. USA, 84:5277–5281, 1987.
33. Whitfield, J. F., MacManus, J. P., Boynton, A. L. Durkin, I., and Jones, A. Future of calcium, calcium-binding proteins, cyclic AMP and protein kinase in the quest for an understanding of cell proliferation and cancer. In:R. A. Corradino (ed.), Functional Regulation at the Cellular and Molecular Levels, pp. 61–87. New York:Elsevier/North-Holland, 1982.
34. Ballester, R., Furth, M. E., and Rosen, O. Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular kirsten ras gene product. J. Biol. Chem., 262:2688–2695, 1987.
35. Stowers, S. J., Glover, P. L., Reynolds, S. H., Boone, L. R., Marenpot, R. R., and Anderson, M. W. Activation of the K-ras protooncogene in lung tumors from rats and mice chronically exposed to tetranitromethane. Cancer Res., 47:3212–3219, 1987.
36. Inoue, M., Kishimoto, A., Takai, Y., and Nishizuka, Y. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J. Biol. Chem., 252:7610–7616, 1977.
37. Cochet, G, Souvignet, C., Keramidas, M., and Chambaz, E. M. Altered catalytic properties of protein kinase C in phorbol ester treated cells. Biochem. Biophys. Res. Commun., 134:1031–1037, 1986.
38. Nishizuka, Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond.), 334:661–665, 1988.
39. Kosaka, Y., Ogita, K., Ase, K., Nomura, H., Kikkawa, U., and Nishizuka, Y. The heterogeneity of protein kinase C in various rat tissues. Biochem. Biophys. Res. Commun., 151:973–981, 1988.
40. Anderson, W. B., Estnal, A., Tapiovaara, H., and Gopalakrishna, R. Altered subcellular distribution of protein kinase C (a phorbol ester receptor). Possible role in tumor promotion and the regulation of cell growth:relationship to changes in adenylate cyclase activity. J. Cyclic Nucleotide Prot. Phosphor. Res., 19:287–305, 1985.
41. Halsey, D. L., Girard, P. R., Kuo, J. F., and Blackshear, P. J. Protein kinase C in fibroblasts:characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens. J. Biol. Chem., 262:2234–2243, 1987.
42. Gopalakrishna, R., and Barsky, S. H. Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. Proc. Natl. Acad. Sci. USA, 85:612–616, 1988.
43. Homma, Y., Henning-Chubb, C. B., and Huberman, E. Translocation of protein kinase C in tumor leukemia cells susceptible or resistant to differentiation induced by phorbol 12-myristate-13-acetate. Proc. Natl. Acad. Sci. USA, 83:7316–7319, 1986.
44. Rozengurt, E., Murray, M., Zachary, I., and Collins, M. Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells:Inhibition by pertussis toxin. Proc. Natl. Acad. Sci. USA, 84:2282–2286, 1987.
45. Kelleher, D. J., Pessin, J. E., Ruoho, A. E., and Johnson, G. L. Phorbol esters induce desensitization of adenylate cyclase and phosphorylation of the 0-adrenergic receptors in turkey erythrocytes. Proc. Natl. Acad. Sci. USA, 87:4316–4320, 1984.
46. Droms, K. A., Haley, B. E., Smith, G. J., and Malkinson, A. M. Decreased 8-N3-[γ-32P]GTP photolabeling of Gsa. in tumorigenic lung epithelial cell lines:association with decreased hormone responsiveness and loss of contact-inhibited growth. Exp. Cell. Res., 182:330–339, 1989.