G Proteins and Regulation of Adenylyl Cyclase

JAMA: The Journal of the American Medical Association

Volumn 262, Issue 13, 1989, Pages 1819-1825

  Gilman, Alfred G ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN;

ACHIEVEMENT; ANIMAL; BIOCHEMISTRY; CELL MEMBRANE; PHYSIOLOGY; PROTEIN CONFORMATION; REVIEW; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMAL; AWARDS AND PRIZES; BIOCHEMISTRY; CELL MEMBRANE; GTP-BINDING PROTEINS; PROTEIN CONFORMATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024417344     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1989.03430130095041     Document Type: Article

References (81)

1. Rail TW, Sutherland EW, Berthet J. The relationship of epinephrine and glucagon to liver phosphorylase, IV: effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates. J Biol Chem. 1957;224:463-475.
2. Rall TW, Sutherland EW. The regulatory role of adenosine-3′,5′-phosphate. Cold Spring Harbor Symp Quant Biol. 1961;26:347-354.
3. Murad F, Chi Y-M, Rall TW, et al. Adenyl cyclase, III: the effect of catecholamines and choline esters on the formation of adenosine 3′,5′-phosphate by preparations from cardiac muscle and liver. J Biol Chem. 1962;237:1233-1238.
4. Aurbach GD, Fedak SA, Woodard CJ, et al. β-Adrenergic receptor: stereospecific interaction of iodinated β-blocking agent with high affinity site. Science. 1974;186:1223-1224.
5. Lefkowitz RJ, Mukherjee C, Coverstone M, et al. Stereospecific [3H]( — )-alprenolol binding sites, β-adrenergic receptors and adenylate cyclase. Biochem Biophys Res Commun. 1974;69:703-710.
6. Limbird LE, Lefkowitz RJ. Resolution of β-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. J Biol Chem. 1977;252:799-802.
7. Haga T, Haga K, Gilman AG. Hydrodynamic properties of the β-adrenergic receptor and adenylate cyclase from wild-type and variant S49 lymphomacells. J Biol Chem. 1977;252:5776-5782.
8. Rodbell M, Birnbaumer L, Pohl SL, et al. The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver, V: an obligatory role of guanyl nucleotides in glucagon action. J Biol Chem. 1971;246:1877-1882.
9. Cassel D, Selinger Z. Catecholamine-stimulated GTPase activity in turkey erythrocytes. Biochem Biophys Acta. 1976;452:538-551.
10. Schramm M, Rodbell M. A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes. J Biol Chem. 1975;250:2232-2237.
11. Maguire ME, Van Arsdale PM, Gilman AG. An agonist-specific effect of guanine nucleotides on binding to the β-adrenergic receptor. Mol Pharmacol. 1976;12:335-339.
12. Bourne HR, Coffino P, Tomkins GM. Selection of a variant lymphoma cell deficient in adenylate cyclase. Science. 1975;187:750-752.
13. Ross EM, Gilman AG. Reconstitution of catecholamine-sensitive adenylate cyclase activity: interaction of solubilized components with receptorreplete membranes. Proc Natl Acad Sci USA. 1977;74:3715-3719.
14. Ross EM, Gilman AG. Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem. 1977;252:6966-6969.
15. Ross EM, Howlett AC, Ferguson KM, et al. Reconstitution of hormone sensitive adenylate cyclase activity with resolved components of the enzyme. J Biol Chem. 1978;253:6401-6412.
16. Northup JK, Sternweis PC, Smigel MD, et al. Purification of the regulatory component of adenylate cyclase. Proc Natl Acad Sci USA. 1980; 77:6516-6520.
17. Sternweis PC, Northup JK, Smigel MD, et al. The regulatory component of adenylate cyclase: purification and properties. J Biol Chem. 1981; 256:11517-11526.
18. Bitensky MW, Wheeler GL, Yamazaki A, et al. Cyclic-nucleotide metabolism in vertebrate photoreceptors: a remarkable analogy and unraveling enigma. Curr Top Memb Trans. 1981;15:237-271.
19. Fung BK-K, Hurley JB, Stryer L. Flow of information in the light-triggered cyclic nucleotide cascade of vision. Proc Natl Acad Sci USA. 1981;78:152-156.
20. Gilman AG. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987; 56:615-649.
21. Stryer L. Cyclic GMP cascade of vision. Annu Rev Neurosci. 1986;9:87-119.
22. Howlett AC, Gilman AG. Hydrodynamic properties of the regulatory component of adenylate cyclase. J Biol Chem. 1980;255:2861-2866.
23. Northup JK, Smigel MD, Sternweis PC, et al. The subunits of the stimulatory regulatory component of adenylate cyclase: resolution of the activated 45,000-dalton (a) subunit. J Biol Chem. 1983;258:11369-11376.
24. Fung BK-K. Characterization of transducin from bovine retinal rod outer segments, I: separation and reconstitution of subunits. J Biol Chem. 1983;258:10495-10502.
25. Ferguson KM, Higashijima T, Smigel MD, et al. The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. J Biol Chem. 1986;261:7393-7399.
26. Brandt DR, Ross EM. Catecholamine-stimulated GTPase cycle: multiple sites of regulation by β-adrenergic receptor and Mg + studied in reconstituted receptor-Gs vesicles. J Biol Chem. 1986;261:1656-1664.
27. Moss J, Vaughan M. Mechanism of action of choleragen: evidence for ADP-ribosyltransferase activity with arginine as an acceptor. J Biol Chem. 1977;252:2455-2457.
28. Gill DM, Meren R. ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase. Proc Natl Acad Sci USA. 1978;75:3050-3054.
29. Cassel D, Pfeuffer T. Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide—binding of adenylate cyclase. Proc Natl Acad Sci USA. 1978;75:2669-2673.
30. Katada T, Ui M. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci USA. 1982;79:3129-3133.
31. Cassel D, Selinger Z. Mechanism of adenylate cyclase activation by cholera toxin: an inhibition of GTP hydrolysis at the regulatory site. Proc Natl Acad Sci USA. 1977;74:3307-3311.
32. Van Dop C, Yamanaka G, Steinberg F, et al. ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors. J Biol Chem. 1984;259:23-25.
33. Yatani A, Codina J, Imoto Y, et al. A G protein directly regulates mammalian cardiac calcium channels. Science. 1987;238:1288-1292.
34. Robishaw JD, Smigel MD, Gilman AG. Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem. 1986;261: 9587-9590.
35. Bray P, Carter A, Simons C, et al. Human cDNA clones for four species of Gαs. Proc Natl Acad Sci USA. 1986;83:8893-8897.
36. Kozasa T, Itoh H, Tsukamoto T, et al. Isolation and characterization of the human Gsα gene. Proc Natl Acad Sci USA. 1988;85:2081-2085.
37. Graziano MP, Freissmuth M, Gilman AG. Expression of Gsα in Escherichia coli: purification and properties of two forms of the protein. J Biol Chem. 1989;264:409-418.
38. Mattera R, Graziano MP, Yatani A, et al. Bacterially synthesized splice variants of the a subunit of the G protein Gs activate both adenylyl cyclase and dihydropyridine-sensitive calcium channels. Science. 1989;243:804-807.
39. Jones DT, Reed RR. Golf, an olfactory neuron specific G protein involved in odorant signal transduction. Science. 1989;244:790-795.
40. Lancet D, Pace U. The molecular basis of odor recognition. Trends Biochem Sci. 1987;12:63-66.
41. Bokoch GM, Katada T, Northup JK, et al. Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem. 1983;258:2072-2075.
42. Bokoch GM, Katada T, Northup JK, et al. Purification and properties of the inhibitory guanine nucleotide—binding regulatory component of adenylate cyclase. J Biol Chem. 1984;259:3560-3567.
43. Nukada T, Tanabe T, Takahashi H, et al. Primary structure of the α-subunit of bovine adenylate cyclase—inhibiting G-protein deduced from the cDNA sequence. FEBS Lett. 1986;197:305-310.
44. Itoh H, Kozasa T, Nagata S, et al. Molecular cloning and sequence determination of cDNAs for a subunits of the guanine nucleotide—binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci USA. 1986;83:3776-3780.
45. Jones DT, Reed RR. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem. 1987;262: 14241-14249.
46. Itoh H, Toyama R, Kozasa T, et al. Presence of three distinct molecular species of Gi protein a subunit: structure of rat cDNA and human genomic DNAs. J Biol Chem. 1988;263:6656-6664.
47. Yatani A, Mattera R, Codina J, et al. The G protein—gated atrial K+ channel is stimulated by three distinct Gi α-subunits. Nature. 1988;336:680-682.
48. Ewald DA, Sternweis PC, Miller RJ. Guanine nucleotide—binding protein Go-induced coupling of neuropeptide Y receptors to Ca + channels in sensory neurons. Proc Natl Acad Sci USA. 1988;85: 3633-3637.
49. Yatani A, Codina J, Brown AM, et al. Direct activation of mammalian atrial muscarinic potassium channel by GTP regulatory protein GK. Science. 1987;235:207-211.
50. Hescheler J, Rosenthal W, Trautwein W, et al. The GTP-binding protein, Go, regulates neuronal calcium channels. Nature. 1987;325:445-447.
51. Sternweis PC, Robishaw JD. Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain. J Biol Chem. 1984;259:13806-13813.
52. Neer EJ, Lok JM, Wolf LG. Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase. J Biol Chem. 1984;259:14222-14229.
53. Lerea CL, Somers DE, Hurley JB, et al. Identification of specific transducin a subunits in retinal rod and cone photoreceptors. Science. 1986;234:77-80.
54. Fong HKW, Yoshimoto K, Eversole-Cire P, et al. Identification of a GTP-binding protein a subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. Proc Natl Acad Sci USA. 1988;85:3066-3070.
55. Matsuoka M, Itoh H, Kozasa T, et al. Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin—insensitive guanine nucleotide— binding regulatory protein a subunit. Proc Natl Acad Sci USA. 1988;85:5384-5388.
56. Northup JK, Sternweis PC, Gilman AG. The subunits of the stimulatory regulatory component of adenylate cyclase: resolution, activity, and properties of the 35,000-dalton (β) subunit. J Biol Chem. 1983;258:11361-11368.
57. Florio V, Sternweis PC. Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles. J Biol Chem. 1989;264:3909-3915.
58. Sternweis PC. The purified a subunits of Go and Gi from bovine brain require βγ for association with phospholipid vesicles. J Biol Chem. 1986;261: 631-637.
59. Sugimoto K, Nukada T, Tanabe T, et al. Primary structure of the β-subunit of bovine transducin deduced from the cDNA sequence. FEBS Lett. 1985;191:235-240.
60. Fong HKW, Amatruda TT, Birren BW, et al. Distinct forms of the β subunit of GTP-binding regulatory proteins identified by molecular cloning. Proc Natl Acad Sci USA. 1987;84:3792-3796.
61. Gao B, Gilman AG, Robishaw JD. A second form of the β subunit of signal transducing G proteins. Proc Natl Acad Sci USA. 1987;84:6122-6125.
62. Gautam N, Baetscher M, Aebersold R, et al. A G protein gamma subunit shares homology with ras proteins. Science. 1989;24:971-974.
63. Cerione RA, Gierschik P, Staniszewski C, et al. Functional differences in the βγ complexes of transducin and the inhibitory guanine nucleotide regulatory protein. Biochemistry. 1987;26:1485-1491.
64. Casey PJ, Graziano MP, Gilman AG. G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsα. Biochemistry. 1989;28:611-616.
65. Tolkovsky AM, Levitzki A. Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochemistry. 1978;17:3795-3810.
66. Pedersen SE, Ross EM. Functional reconstitution of β-adrenergic receptors and the stimulatory GTP-binding protein of adenylate cyclase. Proc Natl Acad Sci USA. 1982;79:7228-7232.
67. Higashijima T, Ferguson KM, Smigel MD, et al. The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go. J Biol Chem. 1987;262:757-761.
68. Katada T, Bokoch GM, Northup JK, et al. The inhibitory guanine nucleotide—binding regulatory component of adenylate cyclase: properties and function of the purified protein. J Biol Chem. 1984;259:3568-3577.
69. Katada T, Northup JK, Bokoch GM, et al. The inhibitory guanine nucleotide—binding regulatory component of adenylate cyclase: subunit dissociation and guanine nucleotide—dependent hormonal inhibition. J Biol Chem. 1984;259:3578-3585.
70. Katada T, Bokoch GM, Smigel MD, et al. The inhibitory guanine nucleotide—binding regulatory component of adenylate cyclase: subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc and wild type membranes. J Biol Chem. 1984;259:3586-3595.
71. Gilman AG. G proteins and dual control of adenylate cyclase. Cell. 1984;36:577-579.
72. Katada T, Oinuma M, Ui M. Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide—-binding proteins serving as the substrate of islet-activating protein, pertussis toxin. J Biol Chem. 1986;261:5215-5221.
73. Katada T, Kusakabe K, Oinuma M, et al. A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. J Biol Chem. 1987;262:11897-11900.
74. Logothetis DE, Kurachi Y, Galper J, et al. The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 1987; 325:321-326.
75. Logothetis DE, Kim D, Northup JK, et al. Specificity of action of the inhibitory guanine nucleotide—binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc Natl Acad Sci USA. 1988;85:5814-5818.
76. Brown AM, Birnbaumer LB. Direct G protein gating of ion channels. Am J Physiol. 1988;254: H401-H410.
77. Dietzel C, Kurjan J. The yeast SCG1 gene: a Gα-like protein implicated in the a- and α-factor response pathway. Cell. 1987;50:1001-1010.
78. Kaziro Y. The role of guanosine 5′-triphosphate in polypeptide chain elongation. Biochem Biophys Acta. 1978;505:95-127.
79. McCormick F. ras GTPase activating protein: signal transmitter and signal terminator. Cell. 1989;56:5-8.
80. Krupinski J, Coussen F, Bakalyar HA, et al. Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science. 1989;244:1558-1564.
81. Graziano MP, Gilman AG. Guanine nucleotide— binding regulatory proteins: mediators of transmembrane signaling. Trends Pharmacol Sci. 1987;8:478-481.