Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for colorectal cancer

British Journal of Cancer

Volumn 60, Issue 3, 1989, Pages 406-412

  Begent, R H J ^a   Ledermann, J A ^a   Green, A J ^a   Bagshawe, K D ^a   Riggs, S J ^a   Searle, F ^a   Keep, P A ^a   Adam, T ^a   Dale, R G ^a   Glaser, M G ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE 131; RADIOISOTOPE;

ANTIBODY LABELING; CLINICAL ARTICLE; COLORECTAL CANCER; HUMAN; PRIORITY JOURNAL;

ANTIBODIES, NEOPLASM; CARCINOEMBRYONIC ANTIGEN; COLONIC NEOPLASMS; HUMAN; IODINE RADIOISOTOPES; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; SUPPORT, NON-U.S. GOV'T;

EID: 0024416962     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1989.295     Document Type: Article

References (35)

1. BADGER, C.C., KROHN, K.A., SHULMAN, H., FLOURNY, N. & BERNSTEIN, I.D. (1986). Experimental radioimmunotherapy of murine lymphoma with 13II-labelled anti-T-cell antibodies. Cancer Res., 46, 6223.
2. BAGSHAWE, K.D., SPRINGER, C.J., SEARLE, F. and 4 others (1988). A cytotoxic agent can be generated selectively at cancer sites. Br. J. Cancer, 58, 700.
3. BEGENT, R.H.J., BAGSHAWE, K.D., PEDLEY, R.B. and 8 others (1987). Use of second antibody in radioimmunotherapy. NCI Monographs, 3, 59.
4. BEGENT, R.H.J., KEEP, P.A., GREEN, A. and 6 others (1982). Liposomally entrapped second antibody improves tumour imaging with radiolabelled (first) antitumour antibody. Lancet, ii, 739.
5. BEGENT, R.H.J., KEEP, P.A., SEARLE, F. and 11 others (1986). Radioimmunolocalisation and selection for surgery in recurrent colorectal cancer. Br. J. Surg., 73, 64.
6. BEGENT, R.H.J., LEDERMANN, J.A., SEARLE, F. & BAGSHAWE, K.D. (1986). Prospects for antibody-targeted radiotherapy of cancer. Lancet, 11, 580.
7. BENUA, R.S., CICALE, N.R., SONENBERG, M. & RAWSON, R.W. (1962). The relation of radioiodine dosimetry to results and complications in the treatment of metastatic thyroid cancer. Am. J. Roentgenol., 87, 171.
8. BUCHEGGER, F., VACCA, A., CARREL, S., SCHREYER, M. & MACH, J.-P. (1988). Radioimmunotherapy of human colon carcinoma by 131-I-labelled monoclonal anti-CEA antibodies in a nude mouse model. Int. J. Cancer, 41, 127.
9. CARRASQUILLO, J.A., KROHN, K.A., BEAUMIER, P. and 5 others (1984). Diagnosis of and therapy for solid tumours with radiolabelled antibodies and immune fragments. Cancer Treat. Rep., 68, 317.
10. CERIANO, R.L. & BLANK, E.W. (1988). Experimental therapy of human breast tumours with 1311-Labeled monoclonal antibodies prepared against the human milk fat globule. Cancer Res., 48, 4664.
11. CHIOU, R.K., VESSELLA, R.L., LIMAS, C. and 4 others (1988). Monoclonal antibody-targeted radiotherapy of renal cell carcinoma using a nude mouse model. Cancer, 61, 1766.
12. COVELL, D.G., BARBET, J., HOLTON, O.D., BLACK, D.V., PARKER, R.J. & WEINSTEIN, J.N. (1986). Pharmacokinetics of monoclonal immunoglobulin GI, F(ab')2, and Fab' in mice. Cancer Res., 46, 3969.
13. DENARDO, S.J., DENARDO, G.L., O'GRADY, L.F. and 6 others (1988). Pilot studies of radioimmunotherapy of B cell lymphoma and leukaemia using 1-131 Lym-1 monoclonal antibody. Antibody Immunoconjugates Radiopharmaceut., 1, 17.
14. DYKES, P.W., BRADWELL, A.R., CHAPMAN, C.E. & VAUGHAN A.T.M. (1987). Radioimmunotherapy of cancer: clinical studies and limiting factors. Cancer Treat. Rev., 14, 87.
15. ESTABAN, J.M., COLCHER, D., SUGARBAKER, P. and 6 others (1987). Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb B72.3. Int. J. Cancer, 39, 50.
16. GOLDENBERG, D.M., GAFFAR, S.A., BENNETT, S.J. & BEACH, J.L. (1981). Experimental radioimmunotherapy of a xenografted human colonic tumor (GW-39) producing carcinoembryonic antigen. Cancer Res., 41, 4354.
17. HAMMOND, N.D., MOLDOFSKY, P.J., BEARDSLEY, M.R. & MULHERN, C.B. (1984). External imaging for quantitation of distribution of I-131 F(ab')2 fragments of monoclonal antibody in humans. Med. Phys., 11, 778.
18. HARWOOD, P.J., PEDLEY, R.B., BODEN, J. & ROGERS, G.T. (1987). Significance of the circulatory clearance of tumour-localising IgF and F(ab')2 for potential therapy studied in a CEA-producing xenograft model. Tumour Biol., 8, 19.
19. JONES, D.H., GOLDMAN, A., GORDON, I., PRITCHARD, J., GREGORY, B.J. & KEMSHEAD, J.T. (1985). Therapeutic application of a radiolabelled monoclonal antibody in nude mice xenografted with human neuroblastoma: tumoricidal effects and distribution studies. Int. J. Cancer, 35, 715.
20. LEDERMANN, J.A., BEGENT, R.H.J., BAGSHAWE, K.D. and 5 others (1988). Repeated antitumour antibody therapy in man with suppression of the host response by cyclosporin A. Br. J. Cancer, 58, 654.
21. LEE, Y.-S., BULLARD, E., ZALUTSKY, M.R. and 5 others (1988). Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131-I-radiolabeled murine monoclonal antibody in a human glioma xenograft model. Cancer Res., 48, 559.
22. LEICHNER, P.K., KLEIN, J.L., GARRISON, J.B. and 4 others (1981). Dosimetry of 1311-labeled anti-ferritin in hepatoma: a model for radioimmunoglobulin dosimetry. Int. J. Radiat. Oncol. Biol. Phys., 7, 323.
23. LEICHNER, P.K., KLEIN, J.L., FISHMAN, E.K., SIEGELMAN, S.S., ETTINGER, D.S. & ORDER, S.E. (1984). Comparative tumor dose from 13II-labeled polyclonal anti-ferritin, anti-AFP, and anti- CEA in primary liver cancers. Cancer Drug Delivery, 1, 321.
24. LENHARD, R.E., ORDER, S.E., SPRUNGBERG, J.J., ASBELL, S.O. & LEIBEL, S.A. (1985). Isotopic immunoglobulin: a new systemic therapy for advanced Hodgkins disease. J. Clin. Oncol., 3, 1296.
25. MACH, J.-P., CARREL, S., FORNI, M., RITSCHARD, J., DONATH, A. & ALBERTO, P. (1980). Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma. A critical evaluation. N. Engl. J. Med., 303, 5.
26. OPERATION MANUAL FOR CONTROLS OF PRODUCTION, PRECLINICAL TOXICOLOGY AND PHASE 1 TRIALS OF ANTI TUMOUR ANTIBODIES AND DRUG ANTIBODY CONJUGATES (1986). Br. J. Cancer, 54, 557.
27. ORDER, S.E., STILLWAGON, G.B., KLEIN, J.L. and 10 others (1985). Iodine 131 antiferritin, a new treatment modality in hepatoma: a Radiation Oncology Group Study. J. Clin. Oncol., 3, 1573.
28. RASO, V. (1982). Antibody mediated delivery of toxic molecules to antigen bearing target cells. Immunol. Rev., 62, 93.
29. RIGGS, S.J., GREEN, A.J., BEGENT, R.H.J. & BAGSHAWE, K.D. (1988). Quantitation in 1311-radioimmunotherapy using SPECT. Int. J. Cancer, Suppl. 2, 95.
30. ROSEN, S.T., ZIMMER, M., GOLDMAN-LEIKIN, R. and 10 others (1987). Radioimmunodetection and radioimmunotherapy of cutaneous T-cell lymphomas using an I311-labelled monoclonal antibody: an Illinois Cancer Council Study. J. Clin. Oncol., 5, 562.
31. SHARKEY, R.M., PYKETT, M.J., SIEGAL, J.A., ALGER, E.A., PRIMUS, F.J. & GOLDENBERG, D.M. (1987). Radioimmunotherapy of the GW-39 human colonic tumour xenograft with '31-I-labeled murine monoclonal antibody to carcinoembryonic antigen. Cancer Res., 47, 5672.
32. THOMAS, S.R., MAXAN, H.R. & KEREIAAKES, J.C. (1976). In vivo quantitation of lesion radioactivity using external counting methods. Med. Phys., 3, 253.
33. WHO (1979). Handbook for Reporting Results of Cancer Treatment. Offset Publication, no. 48. WHO: Geneva.
34. WAKABAYASHI, S., OKAMOTO, S. & TANIGUCHI, M. (1984). Antitumour effects of radiolabeled syngeneic monoclonal antimelanoma antibodies, Gann, 75, 707.
35. ZALCBERG, J.R., THOMPSON, C.H., LICHTENSTEIN, M. & MCKENZIE, F.C. (1984). Tumor immunotherapy in the mouse with the use of 131-I-labelled monoclonal antibodies. J. Nati Cancer Inst., 72, 697.