The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay

International Journal of Radiation Oncology, Biology, Physics

Volumn 16, Issue 4, 1989, Pages 973-976

  Stratford, Ian J ^a   Stephens, Miriam A ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Bioreductive drugs; Chemotherapy; Hypoxia; MTT assay

Indexed keywords

1 AZIRIDINO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; ANTINEOPLASTIC AGENT; METRONIDAZOLE; MISONIDAZOLE; MITOMYCIN C; NITROFURAL; RADIOSENSITIZING AGENT; TETRAZOLIUM; TIRAPAZAMINE;

CELL CULTURE; CLONOGENESIS; COLORIMETRY; CYTOCHEMISTRY; CYTOLOGY; CYTOTOXICITY; HAMSTER; HYPOXIA; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTINEOPLASTIC AGENTS; CELL LINE; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; COMPARATIVE STUDY; DRUG SCREENING ASSAYS, ANTITUMOR; HAMSTERS; MITOMYCIN; MITOMYCINS; OXYGEN; RADIATION-SENSITIZING AGENTS; SUPPORT, NON-U.S. GOV'T; TETRAZOLIUM SALTS; THIAZOLES; TRIAZINES;

EID: 0024414046     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/0360-3016(89)90898-5     Document Type: Article

References (24)

1. Sensitization of anti-cancer agents
2. Toxicity of nitro compounds toward hypoxic mammalian cells: dependence upon reduction potential
3. Feasibility of drug screening with panels of human tumour cell lines using a micro-culture tetrazolium assay
4. Exploitation of bioreductive agents with vasoactive drugs
5. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing
6. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity
7. Potentiation of RSU 1069 tumour cytotoxicity by 5-hydroxytryptamine
8. Potentiation of RSU 1069 tumor cytotoxicity by hydralazine: a new approach to selective therapy
9. Factors affecting the oxygen tension around cells growing in plastic Petri dishes
10. Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumour cells
11. Rate of death of hypoxic cells in multicell spheriods
12. Hypoxic sensitizers: Radiobiological studies at the cellular level
13. Hypoxic cells as specific drug targets for chemotherapy
14. The hypoxic tumour cell = A target for selective cancer chemotherapy
15. Potential bioreductive alkylating agents: I, benzoquinone derivatives
16. Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells
17. Radiosensitizing and toxic effects of the 2-nitroimidazole Ro-07-0582 in hypoxic mammalian cells
18. Bioactivation as a model for drug design: Bioreductive alkylation
19. Rapid colourimetric assay for cellular growth and survival application to proliferation and cytotoxicity assays
20. CB 1954 (2,4-dinitro5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells
21. Nitroimidazoles as hypoxiamediated drugs in cancer chemotherapy
22. The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action
23. Classification of antineoplastic agents by their selective toxicities towards oxygenated and hypoxic cells
24. SR 4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells