ANIMAL TOXICOLOGY OF IRON CHELATOR L1

The Lancet

Volumn 334, Issue 8655, 1989, Pages 156-

  Porter, J B ^a   Hoyes, K P ^a   Abeysinghe, R ^a   Huehns, E R ^a   Hider, R C ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEFERIPRONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; HYPERACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; IRON CHELATION; IRON OVERLOAD; LETTER; MOUSE; MUSCLE SPASM; NONHUMAN; PRIORITY JOURNAL; SIDE EFFECT; SWEATING;

ANIMAL; COMPARATIVE STUDY; IRON CHELATING AGENTS; MICE; MICE, INBRED BALB C; PYRIDONES; SUPPORT, NON-U.S. GOV'T;

EID: 0024411805     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(89)90206-7     Document Type: Letter

References (9)

1. Development of iron chelating drugs
2. 1,2-dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload
3. Effective chelation of iron in β thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one
4. In vivo evaluation of hydroxypyridone iron chelators in a mouse model
5. Iron mobilisation from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron binding constant
6. Selection of hydroxypyridin-4-ones for the treatment of iron overload using in vitro and in vivo models
7. Iron chelation studies using desferrioxamine and the potential oral chelator 12-dimethyl-3-hydroxypyridin-4-one in normal and iron overloaded rats