Antiperoxidant effects of dihydropyridine calcium antagonists

Biochemical Pharmacology

Volumn 38, Issue 23, 1989, Pages 4344-4348

  Janero, David R ^a   Burghardt, Barbara ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE; FELODIPINE; NICARDIPINE; NIFEDIPINE; NILUDIPINE; NIMODIPINE; NISOLDIPINE; NITRENDIPINE; PHOSPHOLIPID; SCAVENGER; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ANIMAL CELL; ARTICLE; DRUG CONCENTRATION; HEART MUSCLE FIBER MEMBRANE; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANTIOXIDANTS; CALCIUM CHANNEL BLOCKERS; COMPARATIVE STUDY; DIHYDROPYRIDINES; HEART; LIPID PEROXIDES; MYOCARDIUM; NISOLDIPINE; PHOSPHOLIPIDS; RATS; XANTHINE OXIDASE;

EID: 0024408994     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(89)90537-6     Document Type: Article

References (25)

1. Calcium channel ligands
2. Effects of calcium antagonists on infarcting myocardium
3. Effects of dihydropyridine calcium channel modulators on cardiac sodium channels
4. The role of calcium in ischemie myocardial injury
5. Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury
6. Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)
7. Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists
8. Classification of calcium antagonists
9. Crystal structures of calcium channel antagonists: 2,6-dimethyl-3,5-dicarbomethoxy-4-[2-nitro-,3-cyano-,4-(dimethyl-amino)-, and 2,3,4,5,6-pentafluorophenyl]-1,4-dihydropyridine
10. Calcium antagonists in cerebral/peripheral vascular disorders
11. Analysis of cardiac membrane phospholipid peroxidation kinetics as malondialdehyde: nonspecificity of thiobarbituric acidreactivity
12. Protection of rat myocardial phospholipid against peroxidative injury through Superoxide-(xanthine oxidase)-dependent, iron-promoted Fenton chemistry by the male contraceptive gossypol
13. Superoxide dismutase assay using alkaline dimethylsulfoxide as Superoxide anion-generating system
14. Tight-binding inhibitors—II. Non-steady state nature of inhibition of milk xanthine oxidase by allopurinol and alloxanthine and of human erythrocytic adenosine deaminase by coformycin
15. On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines
16. Determination of Michaelis constants and inhibitor constants
17. Xanthine oxidase
18. Tight binding inhibitors of xanthine oxidase
19. A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes
20. Nifedipine, diltiazem, bepridil and verapamil uptakes into cardiac and smooth muscles
21. Structural analysis of drug molecules in biological membranes
22. Diffusion of dihydropyridine calcium channel antagonists in cardiac sarcolemmal lipid multibilayers
23. Calcium ions, drug action and the heart—with special reference to calcium antagonist drugs
24. Kinetics of binding of membrane-active drugs to receptor sites
25. Possible molecular basis for the pharmacokinetics and pharmacodynamics of three membrane-active drugs: propranolol, nimodipine and amiodarone