Oxidative Metabolism of Spironolactone: Evidence for the Involvement of Electrophilic Thiosteroid Species in Drug-Mediated Destruction of Rat Hepatic Cytochrome P450

Biochemistry

Volumn 28, Issue 12, 1989, Pages 5128-5136

  Decker, Caroline J ^a   Rashed, Mohamed S ^b   Baillie, Thomas A ^b   Maltby, David ^a   Correia, Maria Almira ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DEXAMETHASONE; DRUG METABOLITE; SPIRONOLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; DRUG METABOLISM; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ENZYME INDUCTION; ISOENZYMES; KINETICS; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NADP; OXIDATION-REDUCTION; RATS; RATS, INBRED STRAINS; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTRUM ANALYSIS, MASS; SPIRONOLACTONE; SULFINIC ACIDS; SULFONIC ACIDS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024397272     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00438a033     Document Type: Article

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