The Absolute Configuration and Synthesis of Natural (-)-Dolastatin 10

Journal of the American Chemical Society

Volumn 111, Issue 14, 1989, Pages 5463-5465

  Pettit, George R ^a   Singh, Sheo Bux ^a   Hogan, Fiona ^a   Lloyd Williams, Paul ^a   Herald, Delbert L ^a   Burkett, Douglas D ^a   Clewlow, Paul J ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DOLASTATIN;

DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 0024394570     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja00196a061     Document Type: Article

References (15)

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2. Donati, G. La Conchiglia 1984, May issue.
3. Pettit, G. R.; Kamano, Y.; Herald, C. L.; Tuinman, A. A.; Boettner, F. E.; Kizu, H.; Schmidt, J. M.; Baczynskyj, L.; Tomer, K. B.; Bontems, R. J. J. Am. Chem. Soc. 1987, 109, 6883–6885.
4. The Val-Pro-Leu-(gln)-Thz sequence of dolastatin 3 was found by total synthesis to be entirely in the L-amino acid configuration: Pettit, G. R.; Kamano, Y.; Holzapfel, C. W.; van Zyl, W. J.; Tuinman, A. A.; Herald, C. L.; Baczynskyj, L.; Schmidt, J. M. J. Am. Chem. Soc. 1987, 109, 7581–7582.
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