UDP-glucuronosyltransferases

Pharmacology and Therapeutics

Volumn 43, Issue 2, 1989, Pages 261-289

  Burchell, Brian ^a   Coughtrie, Michael W H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; CYPROHEPTADINE; GLUCURONOSYLTRANSFERASE; ISOENZYME; MORPHINE; OXAZEPAM;

CRIGLER NAJJAR SYNDROME; DRUG GLUCURONIDATION; ENZYME INDUCTION; GENETIC DISORDER; GILBERT DISEASE; HEREDITY; HUMAN; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW;

ANIMAL; GLUCURONOSYLTRANSFERASE; HUMAN; SUPPORT, NON-U.S. GOV'T;

EID: 0024390969     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(89)90122-8     Document Type: Article

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10. Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers
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14. The role of conjugation reactions in detoxication
15. Paracetamol as a test to determine glucuronide formation in man. Effects of inducers and of smoking
16. Properties of a 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase from rat liver
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31. A molecular analysis of biological variations in UDP-glucuronosyltransferase activities
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38. The phosphohydrolase component of the hepatic microsomal glucose-6-phosphatase system is a 36.5 kDa polypeptide
39. Congenital familial non-haemolytic jaundice with kernicterus
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45. Perinatal development of glucuronidation
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48. Separation, purification and characterization of three isoenzymes of UDP-glucuronyltransferase from rat liver microsomes
49. Substrate specificity and characterization of rat liver p-nitrophenol, 3α-hydroxysteroid and 17β-hydroxysteroid UDP-glucuronyltransferases
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51. Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert's syndrome and Crigler-Najjar disease
52. Formation and urinary excretion of cyproheptidine in monkeys, chimpanzees and humans
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54. Carboxylic acids as inhibitors and substrates of UDP-glucuronosyltransferases
55. Expression of a human liver cDNA encoding UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture
56. Induction of UDP-glucose dehydrogenase during development, organ culture and exposure to phenobarbital. Its relation to levels of UDP-glucuronic acid and overall glucuronidation in chicken and mouse
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63. Hepatic microsomal composition studies in the Gunn rat
64. Factors affecting the response of microsomal UDP-glucuronyltransferase to membrane perturbants
65. Strain differences in purified rat hepatic 3α-hydroxysteroid UDP-glucuronosyltransferase
66. Enzymic differentiation in mammalian tissues
67. Hereditary alcoholuric jaundice
68. Topology of endoplasmic reticular enzyme systems and its possible regulatory significance
69. 1-450 gene in the mouse Hepa-1 cell line
70. Nucleotide and deduced amino acid sequence of rat liver 17β-hydroxy steroid UDP-glucuronosyltransferase
71. Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells
72. Cloning of human UDP-glucuronyltransferase cDNAs
73. Phenol UDP-glucuranosyltransferase deficiency in Gunn rats: mRNA levels are considerably reduced
74. Jaundice of the newborn due to novobiocin
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79. Cloning and characterisation of cDNA encoding 3-methylcholanthrene-inducible rat mRNA for UDP-glucuronosyltransferase
80. The full length coding sequence of rat liver androsterone UDP-glucuronosyltransferase cDNA and comparison with other members of this gene family
81. Cloning of cDNAs coding for rat hepatic microsomal UDP-glucuronyltransferases
82. Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA
83. Examination of the substrate specificity of cloned rat kidney phenol UDP-glucuronosyltransferase expressed in COS-7 cells
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85. Promoter-specific activation of RNA polymerase II transcription by Spl
86. Glucuronidation
87. Mechanisms of bile formation, hepatic uptake and biliary excretion
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90. An enzymatic defect in human neonatal jaundice and in Gunn's strain of jaundiced rats
91. Metabolism of ketotifen by human liver microsomes. In vitro characterization of a tertiary amino glucuronidation
92. Differential stimulation of hepatic mono-oxygenase and glucuronidating systems in chick embryo and neonatal rat by glucocorticoids
93. Development of multiple activities of UDP-glucuronosyltransferase in human liver
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95. Differentiation of endoplasmic reticulum in hepatocytes 1 Glucose-6-phosphatase distribution in situ
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102. Rat liver UDP-glucuronyltransferase. Identification of cDNA encoding two enzymes which glucuronidate testosterone, dihydrotestosterone and β-estradiol
103. Differences in UDP-glucuronosyltransferase activities in congenic inbred rats homozygous and heterozygous for the jaundiced locus
104. Cloning and characterisation of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA
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108. Developmental alteration of hepatic UDP-glucuronosyltransferase and sulphotransferase towards androsterone and 4-nitrophenol in Wistar rats
109. Strain differences in rat liver UDP-glucuronyltransferase activity towards androsterone
110. Hepatic oxidative drug metabolism and the microsomal milieu in a rat model of congenital hyperbilirubinaemia
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112. Determination of acetaminophen metabolism: Effects of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways
113. In vitro evidence for the involvement of at least two forms of human liver UDP-glucuronosyltransferase in morphine 3-glucuronidation
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115. Effects of oral contraceptive steroids on acetaminophen metabolism and elimination
116. A comparison of uridine diphosphate-glucuronosyltransferase and other drug metabolising enzyme activities between two mutant strains of Wistar rats with a genetic deficiency in bilirubin or androsterone glucuronidation
117. Studies on the genetic linkage of bilirubin and androsterone UDP-glucuronosyltransferase by cross-breeding two mutant rat strains
118. 1-450 gene
119. The Ah receptor: Binding specificity only for foreign compounds
120. Hereditary hyperbilirubinaemias
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123. Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice
124. A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum
125. Effective glucuronidation of 6α-hydroxylated bile acids by human hepatic and renal microsomes
126. Paracetamol disposition in normal subjects and in patients treated with anti-epileptic drugs
127. Effects of microsomal enzyme induction on paracetamol metabolism in man
128. Isolation and purification of rat liver morphine UDP-glucuronosyltransferase
129. The inducibility and ontogeny of rat liver UDP-glucuronosyltransferase towards furosemide
130. A regulatory polymorphism for rat hepatic cytochrome P-450g
131. Microsomal azoreduction and glucuronidation in the metabolism of dimethyl aminoazobenzene by rat liver
132. Distribution of UDP-glucuronosyltransferase in rat tissue
133. Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase
134. Isolation of multiple normal and functionally defective forms of uridine diphosphateglucuronosyltransferase from inbred Gunn rats
135. Sex differences in the excretion of glucuronide conjugates: The role of intrarenal glucuronidation
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145. Microsomal membrane integrity and expression of UDP-glucuronyltransferase in response to UDP-N-acetyl glucosamine
146. Congenital jaundice in rats due to the absence of hepatic bilirubin UDP-glucuronyltransferase enzyme protein
147. An investigation of the transverse topology of bilirubin UDP-glucuronosyltransferase in rat hepatic endoplasmic reticulum
148. Induction of the hepatic mixed-function oxidase system by synthetic glucocorticoids. Transcriptional and post-transcriptional regulation
149. Irreversible binding of Zomepirac to plasma protein in vitro and in vivo
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151. Multiple biochemical effects of a series of X-ray induced mutations at the albino locus in the mouse
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153. Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome
154. Drug metabolism in Gunn rats: Inability to increase bilirubin glucuronidation by phenobarbital treatment
155. Induction deficiency of the microsomal UDP-glucuronosyltransferase by 3-methylcholanthrene in Gunn rats
156. Immunochemical characterisation of UDP-glucuronosyltransferase by monoclonal antibody techniques
157. Endogenous esterification of bilirubin by liver microsomes. Evidence for an intramicrosomal pool of UDP-glucose and lumenal orientation of bilirubin UDP-glycosyltransferase
158. Topology and regulation of bilirubin UDP-glucuronyltransferase in sealed native microsomes from rat liver
159. Comparative pharmacokinetics of oxazepam and nortriptyline after single oral doses in man
160. Separation, purification and characterization of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity
161. A direct assay for each translocase of the hepatic microsomal glucose-6-phosphatase system
162. The identification of T2; the phosphate/pyrophosphate transport protein of the hepatic microsomal glucose-6-phosphatase system
163. Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement
164. Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats
165. Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous and Wistar rat livers by pregnenolone-16α-carbonitrile
166. Development of UDP-glucuronosyltransferase activity towards digitoxigenin monodigitoxoside in neonatal rats
167. Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferase
168. Purification and separation of testosterone and oestrone UDP-glucuronyltransferase activities
169. Chloramphenicol in the newborn infant A physiologic explanation of its toxicity when given in excessive doses
170. Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids
171. Precocious development of foetal glucuronidating enzymes induced by glucocorticoids in culture and in vivo
172. Evidence for the metabolism of mitoxanthrone by microsomal glutathione transferases and 3-methylcholanthrene-inducible glucuronosyltransferases
173. Hereditary jaundice and disorders of bilirubin metabolism
174. Urinary excretion of morphine and its metabolites in morphine-dependent subjects
175. Enhancement of UDP-glucuronyltransferase, UDP-glucose dehydrogenase and glutathoine S-transferase activities in rat liver by dietary administration of eugenol