Multivitamin/Folic Acid Supplementation in Early Pregnancy Reduces the Prevalence of Neural Tube Defects

JAMA: The Journal of the American Medical Association

Volumn 262, Issue 20, 1989, Pages 2847-2852

  Milunsky, Aubrey ^a   Jick, Hershel ^b   Jick, Susan S ^b   Bruell, Carol L ^a   Maclaughlin, Dean S ^b   Rothman, Kenneth J ^a   Willett, Walter ^c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c CHANNING LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; MULTIVITAMIN;

ARTICLE; EMBRYO; FEMALE; HUMAN; MAJOR CLINICAL STUDY; NEURAL TUBE DEFECT; PREGNANCY; PRIORITY JOURNAL;

ADULT; ALPHA-FETOPROTEINS; AMNIOCENTESIS; FEMALE; FOLIC ACID; HUMAN; NEURAL TUBE DEFECTS; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, FIRST; PRENATAL CARE; QUESTIONNAIRES; REGRESSION ANALYSIS; SUPPORT, U.S. GOV'T, P.H.S.; VITAMINS;

EID: 0024389016     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1989.03430200091032     Document Type: Article

References (21)

1. Elwood JM, Elwood JH. Epidemiology of Anencephalus and Spina Bifida. New York, NY: Oxford University Press Inc; 1980.
2. Milunsky A. The prenatal diagnosis of neural tube and other congenital defects. In: Milunsky A, ed. Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment. New York, NY: Plenum Press; 1986:453-519.
3. Eichman E, Gesenius H. Die Missgeburtenzunahme in Berlin und Umgebung in den Nachkriegsjahren. Arch Gynakol. 1952;181:168-184.
4. Stein Z, Susser M. Maternal starvation and birth defects. In: Kelly S, Hook E, Janerich D, et al, eds. Birth Defects: Risks and Consequences. New York, NY: Academic Press Inc; 1976:205-220.
5. Edwards JH. Congenital malformations of the central nervous system in Scotland. Br J Prev Soc Med. 1958;12:115-130.
6. Thiersch JB. Therapeutic abortions with a folic acid antagonist, 4-aminopteroyl glutamic acid (4-amino PGA) administered by the oral route. Am J Obstet Gynecol. 1952;63:1298-1304.
7. Seller MJ. Maternal nutrition factors and neural tube defects in experimental animals. In: Dobbing J, ed. Prevention of Spina Bifida and Other Neural Tube Defects. New York, NY: Academic Press Inc; 1983:1-22.
8. Hibbard ED, Smithells RW. Folic acid metabolism and human embryopathy. Lancet. 1965;1:1254.
9. Smithells RW, Sheppard S, Schorah CJ. Vitamin levels and neural tube defects. Arch Dis Child. 1959;51:944-950.
10. Smithells RW, Nevin NC, Seller MJ, et al. Further experience of vitamin supplementation for prevention of NTD recurrences. Lancet. 1983;1: 1027-1031.
11. Laurence KM, James N, Miller MH, et al. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural tube defects. Br Med J. 1981;282:1509-1511.
12. Holmes-Siedle M, Lindenbaum RH, Galliard A, et al. Vitamin supplementation and neural tube defects. Lancet. 1982;1:276.
13. Seller M, Nevin N. Periconceptional vitamin supplementation and the prevention of neural tube defects in southeast England and Northern Ireland. J Med Genet. 1984;21:325.
14. Mulinare J, Cordero JF, Erickson JD, Berry RJ. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA. 1988;260:3141-3145.
15. Consumer and Food Economics Institute. Composition of Foods. Washington, DC: US Dept of Agriculture; 1976-1988. Handbook 8 Series.
16. Perloff B, Bertrum RR. Folacin in selected foods. J Am Diet Assoc. 1977;70:161-170.
17. Carter CO. Clues to the aetiology of neural tube malformations. Dev Med Child Neurol. 1974;16(suppl 32):3-15.
18. Herbert VD, Coleman N. Folic acid and vitamin B-12. In: Shils ME, Young VR, eds. Modern Nutrition in Health and Disease. Philadelphia, Pa: Lea & Febiger; 1988:404.
19. Rothman KJ, Boice JD. Epidemiologic Analysis With a Programmable Calculator. Boston, Mass: Epidemiology Resources Inc; 1982.
20. Mills JL, Rhoads GG, Simpson JL, et al. The absence of a relation between the periconceptional use of vitamins and neural-tube defects. N Engl J Med. 1989;321:430-435.
21. Klemetti A, Saxén L. Prospective vs retrospective approach in the search for environmental causes of malformations. Am J Public Health. 1967;57:2071-2075.