Heterogeneity of chromosomal breakage levels in epithelial tissue of ataxia-telangiectasia homozygotes and heterozygotes

Human Genetics

Volumn 83, Issue 2, 1989, Pages 133-138

  Rosin, Miriam P ^a,b   Ochs, H D ^c   Gatti, R A ^d   Boder, E ^d  

^a SIMON FRASER UNIVERSITY   (Canada)

^b BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA TELANGIECTASIA; CHROMOSOME BREAKAGE; CLINICAL ARTICLE; CYTOLOGY; EPITHELIUM; HEREDITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; MICRONUCLEUS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ATAXIA TELANGIECTASIA; CHILD; CHROMOSOME ABERRATIONS; EPITHELIUM; FEMALE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; MIDDLE AGE; MOUTH MUCOSA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; VARIATION (GENETICS);

EID: 0024385973     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/BF00286705     Document Type: Article

References (60)

1. Evolution of chromosomal abnormalities in sequential cytogenetic studies of telangiectasia
2. Probable involvement of immunoglobulin superfamily genes in most recurrent chromosomal rearrangements from ataxia telangiectasia
3. Evidence for an elevated frequency of in vivo somatic cell mutations in ataxia telangiectasia
4. Detection of nuclear anomalies in the colonic epithelium of the mouse
5. Cytogenetic study of patients with ataxia-telangiectasia
6. Cytogenetic investigations in families with ataxia-telangiectasia
7. Ataxia telangiectasia: chromosomal stability in continuous lymphoblastoid cells
8. Specificity of bleomycin-induced cytotoxic effects on ataxia telangiectasia lymphoid cell lines
9. Ataxia telangiectasia, evaluation of radiosensitivity in cultured skin fibroblasts as a diagnostic test
10. Chromosome translocations and human cancer
11. Chromosome breakage factors: origin and possible significance
12. Oncogenes and tumor-suppressing genes
13. Chromosome aberrations and oncogenes
14. Chromosome breakage and blastic transformation of lymphocytes in ataxia-telangiectasia
15. Ataxia telangiectasia syndrome: cytogenetic and cancer aspects
16. Chromosomal instability syndromes
17. Leukaemia and lymphocytes in ataxia-telangiectasia
18. Ataxia telangiectasia-clonal growth of translocation lymphocytes
19. The micronucleus assay. I. In vivo
20. Measurement of chromosomal breakage in cultured cells by the micronucleus technique
21. The micronucleus assay. II. In vitro
22. Genetic heterogeneity in ataxiatelangiectasia studied by cell fusion
23. Complementation analysis of ataxia-telangiectasia
24. The influence of culture medium composition on the incidence of chromosomal breakage
25. The role of gene dosage and genetic transpositions in carcinogenesis
26. Chromosomal instability in ataxia telangiectasia
27. Akute lymphoblastische Leukämie bei Geschwistern mit progressiven Kleinhirnataxia (Louis-Bar-Syndrom)
28. Evidence for increased somatic cell mutations at the glycophorin A locus in atomic bomb survivors
29. The cellular and molecular responses of ataxiatelangiectasia cells to DNA damages
30. Atypical lymphoid leukemia in ataxia telangiectasia
31. Chromosome breakage in ataxia-telangiectasia
32. Somatic rearrangement of chromosome 14 in human lymphocytes
33. Specific chromosome aberrations in ataxia telangiectasia
34. Chromosomal abnormalities in ataxia-telangiectasia (Louis-Bar syndrome)
35. Antigenotoxic activity of carotenoids in carcinogenexposed populations
36. Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells
37. In vivo chromosomal instability in ataxia-telangiectasia homozygotes and heterozygotes
38. The identification of antigenotoxic/anticarcinogenic agents in food
39. Use of intermediate endpoints in quantitating the response of precancerous lesions to chemopreventine agents
40. Cytogenetic findings in two brothers with ataxia telangiectasia (Louis Bar's syndrome)
41. A diffusable clastogenic factor in ataxia-telangiectasia
42. Epidemiology of cancer in ataxia-telangiectasia
43. Micronuclei in exfoliated human cells as an internal dosimeter for exposures to carcinogens
44. Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells
45. Micronuclei in exfoliated human cells as a tool for studies in cancer risk and cancer intervention
46. The micronucleus test on exfoliated human cells
47. Heritable fragile sites on human chromosomes. I. Factors affecting expression in lymphocyte culture
48. Genetics and epidemiology of ataxia-telangiectasia
49. Malignant neoplasms in the families of patients with ataxia telangiectasia
50. The incidence and gene frequency of ataxia telangiectasia in the United States
51. Breast and other cancers in families with ataxia-telangiectasia
52. Cytogenetics of ataxia-telangiectasia
53. Spontaneous cytogenetic abnormalities in lymphocytes from thirteen patients with ataxia-telangiectasia
54. Variant forms of ataxia telangiectasia
55. Nuclear aberrations as a short-term test for genotoxicity to the colon: evaluation of nineteen agents in mice
56. Bloom syndrome: a single complementation group defines patients of diverse ethinic origin