Mosaicism in the Expression of Tumor-associated Carbohydrate Antigens in Human Colonic and Gastric Cancers

Cancer Research

Volumn 49, Issue 13, 1989, Pages 3662-3669

  Nakasaki, Hisao ^a,b   Clausen, Henrik ^a   Hakomori, Sen itiroh ^a   Mitomi, Toshio ^b   Noto, Takashi ^b   Ogoshi, Kyoji ^b   Hanaue, Hitoshi ^b   Tanaka, Yutaka ^b   Makuuchi, Hiroyasu ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE ANTIGEN; TUMOR ANTIGEN;

CELL DIFFERENTIATION; COLON CANCER; HISTOCHEMISTRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH CANCER;

ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CARBOHYDRATE SEQUENCE; CARBOHYDRATES; CELL DIFFERENTIATION; COLONIC NEOPLASMS; FEMALE; GLYCOSYLATION; HUMAN; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; STOMACH NEOPLASMS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024383538     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Hakomori, S. Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspective. Cancer Res., 45: 2405–2414, 1985.
2. Fukushi, Y., Hakomori, S., and Shephard, T. Localization and alteration of mono-, di-, and trifucosyl α1 → 3 type 2 chain structures during human embryogenesis and in human cancer. J. Exp. Med., 159: 506–520, 1984.
3. Fukushi, Y., Nudelman, E., Levery, S. B., Rauvala, H., and Hakomori, S. Novel fucolipids accumulating in human cancer III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3-NeuAcV3III3Fuc2nLc6). J. Biol. Chem., 259: 10511–10517, 1984.
4. Magnani, J. L., Nilsson, B., Brockhaus, M., Zopf, D., Steplewski, Z., Koprowski, H., and Ginsburg, V. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J. Biol. Chem., 257: 14365–14369, 1982.
5. Kaizu, T., Levery, S. B., Nudelman, E., Stenkamp, R. E., and Hakomori, S. Novel fucolipids of human adenocarcinoma: VI. Monoclonal antibody specific for trifucosyl Ley (III3FucV3FucVI2FucnLc6), and a possible three-dimensional epitope structure. J. Biol. Chem., 261: 11254–11258, 1986.
6. Nudelman, E., Levery, S. B., Kaizu, T., and Hakomori, S. Novel fucolipids of human adenocarcinoma: characterization of the major Ley antigen of human adenocarcinoma as trifucosylnonaosyl Ley glycolipid (III3FucV3FucVI2FucnLc6). J. Biol. Chem., 261: 11247–11253, 1986.
7. Kim, Y. S., Yuan, M., Itzkowitz, S. H., Sun, Q., Kaizu, T., Palekar, A., Trump, B. F., and Hakomori, S. Expression of Ley and extended Ley blood group-related antigens in human malignant, premalignant, and nonmalignant colonic tissues. Cancer Res., 46: 5985–5992, 1986.
8. Kim, Y. S., Itzkowitz, S. H., Yuan, M., Chung, Y., Satake, K., Umeyama, K., and Hakomori, S. Lex and Ley antigen expression in human pancreatic cancer. Cancer Res., 48: 475–482, 1988.
9. Nudelman, E., Hakomori, S., Kannagi, R., Levery, S. B., Yeh, M-Y., Hellstrom, K-E., and Hellstrom, I. Characterization of a human melanoma-associated ganglioside antigen defined by a monoclonal antibody, 4.2. J. Biol. Chem., 257: 12752–12756, 1982.
10. Pukel, C. S., Lloyd, K. O., Travassos, L. R., Dippold, W. G., Oettgen, H. F., and Old, L. J. GD3, a prominent ganglioside of human melanoma: detection and characterization by mouse monoclonal antibody. J. Exp. Med., 155: 1133–1147, 1982.
11. Tai, T., Paulson, J. C., Cahan, L. D., and Irie, R. F. Ganglioside GM2 as a human tumor antigen (OFA-I-1). Proc. Natl. Acad. Sci. USA, 80: 5392–5396, 1983.
12. Cahan, L. D., Irie, R. F., Singh, R., Cassidenti, A., and Paulson, J. C. Identification of human neuroectodermal tumor antigen (OFA-I-2) as ganglioside GD2. Proc. Natl. Acad. Sci. USA, 79: 7629–7633, 1982.
13. Bremer, E. G., Levery, S. B., Sonnino, S., Ghidoni, R., Canevari, S., Kannagi, R., and Hakomori, S. Characterization of a glycosphingolipid antigen defined by the monoclonal antibody MBrl expressed in normal and neoplastic epithelial cells of human mammary gland. J. Biol. Chem., 259: 14773–14777, 1984.
14. Schrump, D. S., Furukawa, K., Yamaguchi, H., Lloyd, K. O., and Old, L. J. Recognition of galactosylgloboside by monoclonal antibodies derived from patients with primary lung cancer. Proc. Natl. Acad. Sci. USA, 85: 4441–4445, 1988.
15. Springer, G. F., Desai, P. R., and Banatwala, I. Blood group MN specific substances and precursors in normal and malignant human breast tissue. Naturwissenschaften, 61: 457–458, 1974.
16. Hirohashi, S., Clausen, H., Yamada, T., Shimosato, Y., and Hakomori, S. Blood group A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and -81 expressed in cancer of blood group O or B individuals: its identification as Tn antigen. Proc. Natl. Acad. Sci. USA, 82: 7039–7043, 1985.
17. Kjeldsen, T., Clausen, H., Hirohashi, S., Ogawa, T., Iijima, H., and Hakomori, S. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2→6 α-N-acetylgalactosaminyl (sia-losyl-Tn) epitope. Cancer Res., 48: 2214–2220, 1988.
18. Kurosaka, A., Kitagawa, H., Fukui, S., Numata, Y., Nakada, H., Funakoshi, I., Kawasaki, T., Ogawa, T., Iijima, H., and Yamashina, I. A monoclonal antibody that recognizes a cluster of a disaccharide, NeuAcα2→6GalNAc, in mucin-type glycoproteins. J. Biol. Chem., 263: 8724–8726, 1988.
19. Chen, F-M., Naeve, G. S., and Epstein, A. L. Comparison of Mono Q, Superose-6, and ABx fast protein liquid chromatography for the purification of IgM monoclonal antibodies. J. Chromatogr., 444: 153–164, 1988.
20. Abe, K., McKibbin, J. M., and Hakomori, S. The monoclonal antibody directed to difucosylated type 2 chain (Fucαl→2Galα1→4[Fucαl → 3]-GlcNAcβ1-R; Y determinant). J. Biol. Chem., 258: 11793–11797, 1983.
21. Itzkowitz, S. H., Yuan, M., Fukushi, Y., Palekar, A., Phelps, P. C., Shamsuddin, A. M., Trump, B. S., Hakomori, S., and Kim, Y. S. Lewisx- and sialylated Lewisx-related antigen expression in human malignant and non-malignant colonic tissues. Cancer Res., 46: 2627–2632, 1986.
22. Larson, S. M. Radiolabeled monoclonal anti-tumor antibodies in diagnosis and therapy. J. Nucl. Med., 26: 538–545, 1985.
23. Chatal, J-F., Thedrez, P., Blottiere, H., Kremer, M., Bianco-Arco, A., Douillard, J-Y., Curtet, C., Maurel, C., and Le Mevel, B. Comparative characteristics of 17.1 A and GA-733 monoclonal antibodies for immunoscintigraphic application. Hybridoma, 5: S87–S96, 1986.
24. Heiner, J. P., Miraldi, F., Kallick, S., Makley, J., Neely, J., Smith-Mensah, W. H., and Cheung, N.-K.V. Localization of GD2-specific monoclonal antibody 3F8 in human osteosarcoma. Cancer Res., 47: 5377–5381, 1987.