Intrathecal Baclofen for Severe Spinal Spasticity

New England Journal of Medicine

Volumn 320, Issue 23, 1989, Pages 1517-1521

  Penn, Richard D ^a   Savoy, Suzanne M ^a   Corcos, Daniel ^b   Latash, Mark ^a   Gottlieb, Gerald ^a   Parke, Barbara ^a   Kroin, Jeffrey S ^a  

^a St Luke's Medical Center   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACLOFEN;

CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; INTRATHECAL DRUG ADMINISTRATION; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SPASTIC SPINAL PARALYSIS; SPINAL CORD INJURY;

EID: 0024381755     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198906083202303     Document Type: Article

References (12)

1. Yamada S, Perot PL Jr, Ducker TB, Lockard I. Myelotomy for control of mass spasms in paraplegia. J Neurosurg 1976; 45: 683–91.
2. Penn RD, Kroin JS. Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg 1987; 66: 181–5.
3. Müller H, Zierski J, Dralle D, Hoffmann O, Michaelis G. Intrathecal baclofen in spasticity. In: Müller H, Zierski J, Penn RD, eds. Local-spinal therapy of spasticity. Berlin: Springer-Verlag, 1988:155–214.
4. Hattab JR. Review of European clinical trials with baclofen. In: Feldman RG, Young RR, Koella WP, eds. Spasticity: disordered motor control. Chicago: Year Book, 1980:71–85.
5. Penn RD. Intrathecal baclofen for severe spasticity. Ann NY Acad Sci 1988; 531: 157–66.
6. Parke B, Penn RD, Savoy SM, Corcos D. Functional outcome after delivery of intrathecal baclofen. Arch Phys Med Rehabil 1989; 70: 30–2.
7. Nanninga JB, Frost F, Penn RD. Effect of intrathecal baclofen on bladder and sphincter function. J Urol (in press).
8. Knutsson E, Lindblom U, Mårtensson A. Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis. J Neurol Sci 1974; 23: 473–84.
9. Müller H, Zierski J, Dralle D, Krauss D, Mutschler E. Pharmacokinetics of intrathecal baclofen. In: Müller H, Zierski J, Penn RD, eds. Local-spinal therapy of spasticity. Berlin: Springer-Verlag, 1988:223–6.
10. Price GW, Wilkin GP, Turnbull MJ, Bowery NG. Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord? Nature 1984; 307: 71–4.
11. Zieglgänsberger W, Howe JR, Sutor B. The neuropharmacology of baclofen. In: Müller H, Zierski J, Penn RD, eds. Local-spinal therapy of spasticity. Berlin: Springer-Verlag, 1988:37–49.
12. Hankey GJ, Stewart-Wynne EG, Perlman D. Intrathecal baclofen for severe spasticity. Med J Aust 1987; 147: 261.