2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. 12. 1,2-Dihydroquinolylmethyl Analogues with High Activity and Specificity for Bacterial Dihydrofolate Reductase

Journal of Medicinal Chemistry

Volumn 32, Issue 8, 1989, Pages 1942-1949

  Johnson, Jay V ^a   Rauckman, Barbara S ^a   Baccanari, David P ^a   Roth, Barbara ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2,4 DIAMINO 5 PYRIMIDYLMETHYL) 1,2 DIHYDROQUINOLINE DERIVATIVE; 6 [(2,4 DIAMINO 5 PYRIMIDINYL)METHYL] 3 FLUORO 2 (FLUOROMETHYL) 1,2 DIHYDRO 8 METHOXY 2,4 DIMETHYLQUINOLINE; DIHYDROFOLATE REDUCTASE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL CULTURE; CHICKEN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; GRAM POSITIVE BACTERIUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTI-INFECTIVE AGENTS; CHEMISTRY; CHICKENS; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; LIVER; MICROBIAL SENSITIVITY TESTS; PYRIMIDINES; QUINOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0024379036     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00128a042     Document Type: Article

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