Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage

Cell

Volumn 58, Issue 3, 1989, Pages 449-459

  Sosnowski, Barbara A ^a   Belote, John M ^b   McKeown, Michael ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SYRACUSE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE RNA SPLICING; ARTHROPOD; DROSOPHILA; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; SEX DIFFERENCE; SEX DIFFERENTIATION;

ANIMAL; CHROMOSOME MAPPING; DNA MUTATIONAL ANALYSIS; DROSOPHILA MELANOGASTER; FEMALE; GENE EXPRESSION REGULATION; INTRONS; MALE; RIBONUCLEASES; RNA SPLICING; SEX DIFFERENTIATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024378075     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(89)90426-1     Document Type: Article

References (48)

1. Sex determination and dosage compensation in Drosophila melanogaster
2. Sex and the single cell: on the action of major loci affecting sex determination in Drosophila melanogaster
3. Molecular genetic aspects of sex determination in Drosophila
4. RNA-binding proteins as developmental regulators
5. Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins
6. The molecular genetics of transformer a genetic switch controlling sexual differentiation in Drosophila
7. Regulation of sexual differentiation in D melanogaster via alternative splicing of RNA from the transformer gene
8. Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides
9. Developmental expression of a regulatory gene is programmed at the level of splicing
10. Two closely-linked mutations in Drosophila melanogaster that are lethal to opposite sexes and interact with daughterless
11. A male-specific lethal mutation in Drosophila melanogaster that transforms sex
12. Autoregulatory functioning of a Drosophila gene product that establishes and maintains the sexually determined state
13. Primary events in the determination of sex in Drosophila melanogaster
14. New mutants
15. Autogenous regulation of splicing of the transcript of a yeast ribosomal gene
16. pEMBL: a new family of single stranded plasmids
17. A comprehensive set of sequence analysis programs for the VAX
18. GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA
19. Intron splicing: a conserved internal signal in introns of Drosophila pre-mRNAs
20. The white gene as a marker in a new P-element vector for gene transfer in Drosophila
21. Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression
22. Genetic variations of Drosophila melanogaster
23. The genome of Drosophila melanogaster part 1: genes A-K
24. The genome of Drosophila melanogaster part 2: lethals; maps
25. The genome of Drosophila melanogaster part 3: rearrangements
26. The Sex-lethal gene of Drosophila: DNA alterations associated with sex-specific lethal mutations
27. Sex-lethal, a link between sex determination and sexual differentiation in Drosophila melanogaster
28. A molecular analysis of transformer, a gene in Drosophila melanogaster that controls female sexual differentiation
29. Ectopic expression of the female transformer gene product leads to female differentiation of chromosomally male Drosophila
30. The nucleotide sequence and transcript map of the herpes virus thymidine kinase gene
31. The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster
32. Genetic evidence that the sans fille locus is involved in Drosophila sex determination
33. mRNA splicing efficiency in yeast and the contribution of nonconserved sequences
34. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein
35. Intron sequences involved in lariat formation during pre-mRNA splicing
36. A role for exon sequences and splicesite proximity in splice-site selection
37. The role of the mammalian branchpoint sequence in pre-mRNA splicing
38. A stable source of P element transposase in Drosophila melanogaster
39. Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene
40. Genetic transformation of Drosophila with transposable element vectors
41. The Drosophila female-specific sex determination gene Sex-lethal has stage tissue and sex specific RNAs suggesting multiple modes of regulation
42. cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins
43. Transposition of cloned P elements into Drosophila germ line chromosomes
44. Sex determination in Drosophila: the X-chromosomal gene liz is required for Sxl activity
45. Cloning of the human cDNA for the U1 RNA-associated 70K protein
46. Evidence that a regulatory gene autoregulates splicing of its transcript
47. Oligonucleotide directed mutagenesis using phagemid vectors