Elevated Serum Levels of Tumor Necrosis Factor Are Associated With Progressive Encephalopathy in Children With Acquired Immunodeficiency Syndrome

American Journal of Diseases of Children

Volumn 143, Issue 7, 1989, Pages 771-774

  Mintz, Mark ^a,c   Rapaport, Robert ^b   Oleske, James M ^b,c   Connor, Edward M ^b,c   Koenigsberger, M Richard ^a,c   Denny, Tom ^a,b,c   Epstein, Leon G ^a,c  

^a Division of Pediatric Neurology   (United States)

^b Department of Pediatrics ^*  (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TUMOR NECROSIS FACTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; BLOOD LEVEL; BRAIN DISEASE; BRAIN INJURY; CEREBROSPINAL FLUID LEVEL; CHILD; CLINICAL ARTICLE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INFANT; METHODOLOGY; NEUROLOGIC DISEASE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADOLESCENT; BRAIN DISEASES; CACHEXIA; CHILD; CHILD, PRESCHOOL; HUMAN; INFANT; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR NECROSIS FACTOR;

EID: 0024373478     PISSN: 0002922X     EISSN: 15383628     Source Type: Journal    
DOI: 10.1001/archpedi.1989.02150190021012     Document Type: Article

References (30)

1. Unanue ER, Allen PM. The immunoregulatory role of the macrophage. Hosp Pract. 1987;22: 87-104.
2. Old L. Another chapter in the long history of endotoxin. Nature. 1987;330: 602-603.
3. Beutler B, Cerami A. Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response. Endocr Rev. 1988;9: 57-66.
4. Tracey KJ, Yuman F, Hesse DG, et al. Anticachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. Nature. 1986;330: 662-664.
5. Hesse DG, Tracey KJ, Fong Y, et al. Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet. 1988; 166: 147-153.
6. Torti FM, Diechman B, Beutler B, Cerami A, Ringwold GM. A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science. 1985;229: 867.
7. Oliff A, Defeo-Jones D, Boyer M, et al. Tumors secreting human TNF/cachectin induce cachexia in mice. Cell. 1987;50: 555-563.
8. Piguet PF, Grau GE, Allet B, Vassalli P. Tumor necrosis factor is an effector of skin and gut lesions of the acute phase of graft vs host disease. J Exp Med. 1987;166: 1280-1289.
9. Grau GE, Fajardo LF, Piguet P-F, Allet B, Lambert P-H, Vassalli P. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science. 1987;237: 1210-1212.
10. Waage A, Halstensen A, Espevik T. Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet. 1987;1: 355-357.
11. Girardin E, Grau GE, Dayer J-M, Roux-Lombard P, J5 Study Group, Lambert P-H. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med. 1988;319: 397-400.
12. Scuderi P, Sterling KE, Lam KS, et al. Raised serum levels of tumour necrosis factor in parasitic infections. Lancet. 1986;2: 1364-1365.
13. Teppo AM, Maury CPJ. Radioimmunoassay of tumor necrosis factor in serum. Clin Chem. 1987;33: 2024-2027.
14. Lahdevirta J, Maury CPJ, Teppo A-M, Repo H. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med. 1988;85: 289-291.
15. Gallo RC, Salahuddin SZ, Popovic M, et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984;224: 500-504.
16. Ratner L, Polmar SH, Paul N, Ruddle N. Cytotoxic factors secreted by cells infected by human immunodeficiency virus type I. AIDS Res Hum Retroviruses. 1987;3: 147-155.
17. Roux-Lombard P, Modoux C, Cruchard A, Dayer J-M. Use of RIA and bioassay for determination of TNF-alpha in monocyte culture supernatants from HIV-infected patients. Presented at The International Symposium on Clinical Usefulness of Cytokine Radioimmunoassays; April 15, 1988; Brussels, Belgium.
18. Wright SC, Jewett A, Mitsuyasu R, Bonavida B. Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AIDS patients. J Immunol. 1988;141: 99-104.
19. Epstein LE, Sharer LR, Oleske JM, et al. Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics. 1986;78: 678-687.
20. Sharer L, Epstein LG, Cho E-S, et al. Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of brain. Hum Pathol. 1986;17: 271-284.
21. Selmaj KW, Raine CS. TNF mediates myelin and oligodendrocyte damage in vitro. Ann Neurol. 1988;23: 339-346.
22. Robbins D, Shiraze Y, Drysdale B-E, Lieberman A, Shin HS, Shin ML. Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes. J Immunol. 1987;139: 2593-2597.
23. Michaels J, Price RW, Rosenblum MK. Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: proliferation, infection, and fusion. Acta Neuropathol. 1988;76: 373-379.
24. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science. 1988;239: 586-592.
25. Michaels J, Sharer L, Epstein LG. Human immunodeficiency virus type-1 (HIV-1) infection of the nervous system: a review. Immunodeficiency Reviews. 1988;1: 71-104.
26. Connor EM, Minnefor AB, Oleske JM. Human immunodeficiency virus infection in infants and children. In: Gottlieb MS, Feffries DJ, Mildvan D, Pinching AJ, Quinn TC, Weiss RA, eds. Current Topics in Aids. New York, NY: John Wiley & Sons Inc; 1987;1: 185-209.
27. CDC: Revision of the CDC surveillance case definition for the acquired immune deficiency syndrome. MMWR. CDC 1987;36 (suppl): 1-15.
28. Beutler B. The presence of cachectin/tumor necrosis factor in human disease states. Am J Med. 1988;85: 287-288.
29. Breder CD, Dinarello CA, Saper CB. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science. 1988;240: 321-324.
30. Ruddle NH. Lymphotoxin production in AIDS. Immunol Today. 1986;7: 8.