Fk409, a novel vasodilator isolated from the acid-treated fermentation broth of streptomyces griseosporeus. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics

The Journal of Antibiotics

Volumn 42, Issue 11, 1989, Pages 1578-1583

  Hino, Motohiro ^a   Iwami, Morita ^a   Okamoto, Masanori ^a   Yoshida, Keizo ^a   Haruta, Hisae ^a   Okuhara, Masakuni ^a   Hosoda, Junji ^a   Kohsaka, Masanobu ^a   Aoki, Hatsuo ^a   Imanaka, Hiroshi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 ETHYL 2 HYDROXYIMINO 5 NITRO 3 HEXENAMIDE; ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; COLLAGEN; GLYCERYL TRINITRATE; NORADRENALIN; THROMBIN; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL CELL; AORTA; ARTICLE; BLOOD PRESSURE; DRUG ISOLATION; FERMENTATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; STREPTOMYCES GRISEOSPOREUS; TAXONOMY; THROMBOCYTE AGGREGATION; VASODILATATION;

ANIMAL; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; CHEMISTRY, PHYSICAL; FERMENTATION; IN VITRO; MALE; NITRO COMPOUNDS; PLATELET AGGREGATION INHIBITORS; RABBITS; RATS; RATS, INBRED STRAINS; STREPTOMYCES; VASODILATOR AGENTS;

EID: 0024368099     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.42.1578     Document Type: Article

References (16)

1. Yoshida, K.; M. Okamoto, K. Umehara, M. Iwami, M. Kohsaka, H. Aoki & H. Imanaka: Studies on new vasodilators, WS-1228 A and B. I. Discovery, taxonomy, isolation and characterization. J. Antibiotics 35: 151∼156, 1982.
2. Takase, S.; M. Iwami, T. Ando, M. Okamoto, K. Yoshida, H. Horiai, M. Kohsaka, H. Aoki & H. Imanaka: Amauromine, a new vasodilator. Taxonomy, isolation and characterization. J. Antibiotics 37: 1320∼1323, 1984.
3. Ando, T.; Y. Tsurumi, N. Ohata, I. Uchida, K. Yoshida & M. Okuhara: Vinigrol, a novel antihypertensive and platelet aggregation inhibitory agent produced by a fungus, Virgaria nigra. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J. Antibiotics 41: 25∼30, 1988.
4. Umehara, K.; K. Yoshida, M. Okamoto, M. Iwami, H. Tanaka, M. Kohsaka & H. Imanaka: Studies on WF-5239, a new potent platelet aggregation inhibitor. J. Antibiotics 37: 469∼474, 1984.
5. Skirling, E. B. & D. Gottlieb: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313∼340, 1966.
6. Waksman, S. A. (Ed.): The Actinomycetes. Vol. 2. Classification, Identification and Description of Genera and Species. Williams & Wilkins Co., 1961.
7. Pridham, T. G. & D. Gottlieb: The utilization of carbon compounds by some Actinomycetales as an aid for species determination. J. Bacteriol. 56: 107∼114, 1948.
8. Shirling, E. B. & D. Gottlieb: Cooperative description of type cultures of Streptomyces. II. Species descriptions from first study. Int. J. Syst. Bacteriol. 18: 69~189, 1968.
9. Skirling, E. B. & D. Gottlieb: Cooperative description of type cultures of Streptomyces. III. Additional species descriptions from first and second studies. Int. J. Syst. Bacteriol. 18: 279~392, 1968.
10. Shirling, E. B. & D. Gottlieb: Cooperative description of type cultures of Streptomyces. IV. Species descriptions from the second, third and fourth studies. Int. J. Syst. Bacteriol. 19: 391∼512, 1969.
11. Buchanan, R. E. & N. E. Gibbons (Ed.): Bergey's Manual of Determinative Bacteriology. 8th Ed. Williams & Wilkins Co., 1974.
12. Brown, B. G.; E. Bolson, R. B. Petersen, C. D. Pierce & H. T. Dodge: The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response. Circulation 64: 1089∼1097, 1981.
13. Mandellkorn, J. B.; N. M. Wolf, S. Surender, J. A. Shechter, R. I. Kresh, D. M. Rodgers, M. B. Workman, L. G. Bentivoglio, S. M. Laporte & S. G. Meister: Intracoronary thrombus in nontransmural myocardial infarction and unstable angina pectoris. Am. J. Cardiol. 52: 1∼6, 1983.
14. Jules, Y. T. L.; J. H. Chesebro, P. M. Steele & V. Fuster: Is vasospasm related to platelet deposition? Relationship in a porcine preparation of arterial injury in vivo. Circulation 75: 243∼248, 1987.
15. Jules, Y. T. L.; J. H. Chesebro & V. Fuster: Platelets, vasoconstriction, and nitroglycerin during arterial wall injury. A new antithrombotic role for an old drug. Circulation 78: 712∼716, 1988.
16. Hino, M.; T. Ando, S. Takase, Y. Itoh, M. Okamoto, M. Kohsaka, H. Aoki & H. Imanaka: FK409, a novel vasodilator isolated from the acid-treated fermentation broth of Streptomyces griseosporeus. II. Structure of FK409 and its precursor FR-900411. J. Antibiotics 42: 1584~1588, 1989.