Elevated Protein Kinase C Expression in Human Breast Tumor Biopsies Relative to Normal Breast Tissue

Cancer Research

Volumn 49, Issue 12, 1989, Pages 3215-3217

  O’Brian, Catherine A ^a   Ward, Nancy E ^a   Vogel, Victor G ^a   Singletary, S Eva ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE C; RADIOISOTOPE;

BREAST CANCER; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; NORMAL VALUE; PRIORITY JOURNAL;

BIOPSY; BREAST; BREAST NEOPLASMS; HUMAN; PROTEIN KINASE C; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR MARKERS, BIOLOGICAL;

EID: 0024323584     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Coussens, L., Parker, P. J., Rhee, L., Yang-Feng, T. L., Chen, E., Waterfield, M. D., Francke, U., and Ullrich, A. Multiple distinct forms of bovine and human protein kinase C suggest diversity in cellular signalling pathways. Science (Wash. DC), 233: 859–866, 1986.
2. Knopf, J. L., Lee, M-H., Sultzman, L. A., Kriz, R. W., Loomis, C. R., Hewick, R. M., and Bell, R. M. Cloning and expression of multiple protein kinase C cDNAs. Cell, 46: 491–502, 1986.
3. Housey, G. M., O’Brian, C. A., Johnson, M. D., Kirschmeier, P., and Weinstein, I. B. Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family. Proc. Natl. Acad. Sci. USA, 84: 1065–1069, 1987.
4. Nishizuka, Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond.), 334: 661–665, 1988.
5. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem., 257: 7847–7851, 1982.
6. Arcoleo, J. P., and Weinstein, I. B. Activation of protein kinase C by tumor promoting phorbol esters, teleocidin, and aplysiatoxin in the absence of added calcium. Carcinogenesis (Lond.), 6: 213–217, 1985.
7. Nishizuka, Y. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature (Lond.), 308: 693–698, 1984.
8. Nishizuka, Y. Studies and perspectives of protein kinase C. Science (Wash. DC), 233: 305–312, 1986.
9. Housey, G. M., Johnson, M. D., Hsiao, W. L. W., O’Brian, C. A., Murphy, J. P., Kirschmeier, P., and Weinstein, I. B. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell, 52: 343–354, 1988.
10. Persons, D. A., Willdson, W. O., Bell, R. M., and Finn, O. J. Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-l cDNA. Cell, 52: 447–458, 1988.
11. Young, S., Parker, P. J., Ullrich, A., and Stabel, S. Downregulation of protein kinase C is due to an increased rate of degradation. Biochem. J., 244: 775–779, 1987.
12. Darbon, J-M., Valette, A., and Bayard, F. Phorbol esters inhibit the proliferation of MCF-7 cells. Biochem. Pharmacol., 35: 2683–2686, 1986.
13. Fabbro, D., Regazzi, R., Costa, S. D., Borner, G., and Eppenberger, U. Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells. Biochem. Biophys. Res. Commun., 755: 65–73, 1986.
14. O’Brian, C. A., Liskamp, R. M., Solomon, D. H., and Weinstein, I. B. Inhibition of protein kinase C by tamoxifen. Cancer Res., 45: 2462–2465, 1985.
15. O’Brian, C. A., Housey, G. M., and Weinstein, I. B. Protein kinase C binds specifically and directly to an immobilized tamoxifen analogue. Cancer Res., 48: 3626–3629, 1988.
16. O’Brian, C. A., Liskamp, R. M., Solomon, D. H., and Weinstein, I. B. Triphenylethylenes: a new class of protein kinase C inhibitors. J. Natl. Cancer Inst., 76: 1243–1246, 1986.
17. O’Brian, C. A., Lawrence, D. S., Kaiser, E. T., and Weinstein, I. B. Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca22+ or a phorbol ester tumor promoter. Biochem. Biophys. Res. Commun., 124: 296–302, 1984.
18. Kikkawa, U., Takai, Y., Minakuchi, R., Inohara, S., and Nishizuka, Y. Calcium-activated, phospholipid-dependent protein kinase from rat brain: subcellular distribution, purification and properties. J. Biol. Chem., 257: 13341–13348, 1982.
19. O’Brian, C. A., Housey, G. M., and Weinstein, I. B. Binding of protein kinase C to naphthalenesulfonamide and phenothiazine agarose columns: evidence for direct interactions between protein kinase C and cationk am-phiphilic inhibitors of the enzyme. Biochem. Pharmacol., 36: 4179–4181, 1987.
20. Stancel, G. M., and Gorski, J. Analysis of cytoplasmic and nuclear estrogen receptor proteins by sucrose density gradient centrifugation. Methods Enzymol., 36: 166–187, 1975.
21. Bayard, F., Kreitman, B., and Derache, B. Measurement of the progesterone receptor in human endometrium using progesterone and R5020. In: W. L. McGuire (ed.), Progesterone Receptors in Normal and Neoplastic Tissues, pp. 287–297. Raven Press, New York, 1977.
22. Fabbro, D., Kung, W., Roos, W., Regazzi, R., and Eppenberger, U. Epidermal growth factor binding and protein kinase C activities in human breast cancer cell lines: possible quantitative relationship. Cancer Res., 46: 2720–2725, 1986.
23. Wyss, R., Fabbro, D., Regazzi, R., Borner, G., Takahashi, A., and Eppenberger, U. Phorbol ester and epidermal growth factor receptors in human breast cancer. Anticancer Res., 7: 721–728, 1987.
24. Black, M. M., Barclay, T. H., and Hankey, B. F. Prognosis in breast cancer utilizing histologic characteristics of the primary tumor. Cancer (Phila.), 36: 2048–2055, 1975.