Unique role of studies on preimplantatipn embryos to understand mechanisms of embryotoxicity in early pregnancy

Critical Reviews in Toxicology

Volumn 20, Issue 2, 1989, Pages 51-64

  Spielmann, Horst ^a,b   Vogel, Richard ^c,d  

^a Department of Cardiology   (Germany)

^b Federal Health Office   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CADMIUM; CAFFEINE; CHLORAMBUCIL; CHLORAMPHENICOL; CYCLOPHOSPHAMIDE; DIETHYLSTILBESTROL; DOXYCYCLINE; EPIRUBICIN; LEAD; METHYLMERCURY; METHYLNITROSOUREA; PHENOBARBITAL; VINBLASTINE; VINDESINE;

ANIMAL CELL; ANIMAL EXPERIMENT; DNA REPAIR; DRUG METABOLISM; EMBRYO; EMBRYOTOXICITY; FETUS; GENOTOXICITY; HUMAN; NONHUMAN; PREGNANCY; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; REVIEW; SISTER CHROMATID EXCHANGE; TISSUE CULTURE; TOXICITY TESTING; XENOBIOTIC METABOLISM;

ANIMAL; BLASTOCYST; FEMALE; HUMAN; MODELS, BIOLOGICAL; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TERATOGENS; TISSUE CULTURE; TOXICOLOGY;

ANIMALIA;

EID: 0024310212     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.3109/10408448909017903     Document Type: Article

References (97)

1. Paternal exposure to X-ray and chemicals induces heritable tumors and anomalies in mice
2. Induction of congenital malformations in offspring of male mice treated with X-rays at premiotic and postmiotic stages
3. X-ray and chemically induced germ-line mutation causing phenotypical anomalies in mice
4. Induction of congenital malformation in mice by paternal irradiation: transmission to later generations
5. Paternal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility
6. Chronic low-dose cyclophosphamide treatment of adult male rats: effects on fertility, pregnancy outcome, and progeny
7. Increased incidence of abnormal foetuses in the offspring of cyclophosphamide treated male mice
8. Frequency of congenital defects and dominant lethals in the offspring of male mice treated with methylnitrosourea
9. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death
10. Mutagen-induced fetal anomalies and death following treatment of females within hours after mating
11. Teratogenic effects of methylnitrosourea on pregnant mice before implantation
12. Effects of mitomycin C or methylnitrosourea treatment before implantation on mouse fetal development
13. Cytogenetic studies on preimplantation mouse embryos exposed to methylnitrosourea in vivo
14. Abnormal development of mouse embryos exposed to methylnitrosourea before implantation
15. Germline integration of Moloney murine leukemia virus at the Mov 13 locus leads to recessive lethal mutation and early embryonic death
16. An inherited limb deformity created by insterional mutagenesis in transgenic mice
17. Current status in teratology, general principles and mechanisms derived from animal studies
18. Embryotransfer and sensitivity to teratogenesis
19. The molecular and cellular basis of preimplantation mouse development
20. Inhibition of postimplantation development of mouse blastocysts in vitro after cyclophosphamide treatment in vivo
21. Recent progress in teratology: a survey of methods for the study of drug actions during the preimplantation period
22. Investigations on cyclophosphamide treatment during the preimplantation period. I. Differential sensitivity of preimplantation mouse embryos to maternal cyclophosphamide treatment
23. Analysis of embryotoxic effects in preimplantation embryos
24. Chemical exposure of embryos during the preimplantation stages of pregnancy: mortality rate and intrauterine development
25. Developmental toxicology during the preimplantation period: embryotoxicity and clastogenic effects of chorambucil in the rat
26. Maternal administration of cyclophosphamide induces chromosomal aberrations and inhibits cell number, histone synthesis, and DNA synthesis in preimplantation mouse embryos
27. Long-term effects of exposure to methylnitrosourea on blastocysts following transfer to surrogate female mice
28. Reproductive toxicology associated with endometrial cell mediated metabolism of beno(a)pyrene: a combined in vitro, in vivo approach
29. Toxic effects of chemicals on mouse post-blastocyst development — a trial to establish a testing system for embryotoxicity
30. Cultured mouse embryos metabolize benzo(a)pyrene during early gestation: genetic differences detectable by sister chromatid exchange
31. Developmental onset of mixed-function oxidase activity in preimplantation mouse embryos
32. Cytochrome P-450 metabolic activity in embryonic and extraembryonic tissue linages of mouse embryos
33. Oxidative and conjugative metabolism of diethylstilbestrol by rabbit preimplantation embryos
34. In Vitro fertilization and embryo transfer in human beings
35. Very early pregnancy
36. Reproductive loss: how much is preventable?
37. Retrospective and prospective epidemiological studies of 1,500 karyotyped spontaneous human abortions
38. Chromosomal abnormalities in human embryos after in vitro fertilization
39. Preimplantation human embryonic development from polynuclear eggs after in vitro fertilization
40. Chromosome studies in human in vitro fertilization
41. Early mammalian development
42. Investigations on the mechanism of action and on the pharmacokinetic of cyclophosphamide treatment during the preimplantation period in the mouse
43. Potentiating effect of caffeine on embryotoxicity of cyclophosphamide treatment in vivo during the preimplantation period
44. An air drying method for chromosome preparations from mouse eggs
45. Increased sister chromatid exchange frequency in preimplantation mouse embryos after maternal cyclophosphamide treatment before implantation
46. A review of the international symposium on sister chromatid exchanges: twenty five years of experimental research
47. Spontaneous sister chromatid exchanges detected by BUdR labelling method
48. New Giemsa method for the differential staining of sister chromatids
49. Sister chromatid exchanges: a report of the GENE-TOX program
50. utero sister chromatid exchange analysis for detection of transplacental mutagens
51. Sister-chromatid exchange and micronucleus induction as indicators of genetic damage in maternal and foetal cells
52. Early mouse embryos exhibit strain variation in radiation-induced sister chromatid exchange: relationship with DNA repair
53. Abnormal development and transport and increased sister chromatid exchange in preimplantation embryos following superovulation in mice
54. Development and sister chromatid exchange of mouse morulae and blastocysts cultured in rat serum containing active metabolites of cyclophosphamide
55. Inhibition of early postimplantation development of cultured embryos by bromodeoxyuridine
56. Spontaneous and cyclophosphamide induced sister-chromatid exchanges in diploid and endoreduplicated tetraploid metaphases of preimplantation mouse embryos
57. Developmental and cytogenetic effects of caffeine on mouse blastocysts, alone or in combination with benzo(a)pyrene
58. Cytotoxic and genotoxic effects of bromodeoxyuridine during in vitro labelling for sister chromatid differentiation in preimplantation mouse embryos
59. Detection of bromodeoxyuridine incorporation in mammalian chromosomes by a bromodeoxyuridine antibody. II. Demonstration of sister chromatid exchanges
60. The effect of serum fractions on embryo growth
61. Preimplantation mouse embryos cultured in mouse, rat and human sera: differentiation and sister chromatid exchange
62. Studies on mouse-egg radiosensitive from fertilization up to the first cleavage
63. Supraadditive formation of micronuclei in preimplantation mouse embryos in vitro after combined treatment with X-rays and caffeine
64. The combined treatment of preimplantation mouse embryos in vitro with cadmium (CdSO4, CdF2) and X-rays
65. Cadmium toxicity in preimplantation mouse embryo development
66. In Vitro exposure of male and female mice gametes to cadmium chloride during the fertilization process, and its effects on pregnancy outcome
67. Effects of cadmium on preimplantation mouse embryos in vitro with special reference to their implantation capacity and subsequent development
68. Effects of cadmium on lactate dehydrogenase activities in mouse pre-embryos at various stages
69. Zinc amelioration of cadmium toxicity on preimplantation mouse zygetes in vitro
70. Sensitivity of early mouse embryos to methylmercury toxicity
71. Acute effects of mercuric compounds on preimplantation mouse embryos in vitro
72. Recovery of mouse embryos after short-term in vitro exposure to toxic nickel chloride
73. Developmental and cytogenetic effects of potassium dichromate on mouse embryos in vitro
74. Effects on mouse blastocysts of in vitro exposure to methylnitrosourea and 3-methyl-cholanmrene
75. Effect of estradiol, prostaglandin E2, and prostaglandin F2a on incorporation of 3H-uridine by preimplantation mouse embryos in vitro
76. Inhibition of hatching of mouse blastocysts in vitro by prostaglandin antagonists
77. Direct effects of nicotine on rabbit preimplantation embryos
78. Identification of drugs in the preimplantation blastocysts and in the plasma. Uterine secretion and urine of the pregnant rabbit
79. Transfer of drugs into the embryo before and during implantation
80. Ultraviolet light-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation
81. Repair of UV-damage to DNA of implantation stage mouse embryos in vitro
82. Differential sensitivity of preimplantation stage mouse embryos to UV irradiation in vitro and evidence for postreplication repair
83. Endocrinology of the pig blastocyst and its role in the establishment of pregnancy
84. Estrogen formation in the early rabbit embryo
85. Changing 17-hydroxysteroid dehydrogenase activity in preimplantation rat and mouse embryos
86. Metabolism of progesterone by preimplantation mouse blastocysts in culture
87. Characteristics of drugs that penetrate the preimplantation blastocysts
88. Transfer of blastocysts as applied to experimental teratology
89. Teratogenicity of TCDD and congener 3,3′,4,4′-tetrachloroazoxybenzene in sensitive and non-sensitive mouse strains after reciprocal blastocyst transfer
90. The effect of clomiphene citrate on blastocyst development and implantation in the rabbit
91. Effect of short-term exposure to five industrial metals on the embryonic and fetal development in the mouse
92. The effects of actinomycin D and chloramphenicol on the rat preimplantation embryos
93. Effects of cadmium, lead and copper on rat preimplantation embryos
94. Methylmecuric chloride administered to pregnant rats during preimplantation period
95. Beneficial effects of ascorbic acid on preimplantation mouse embryos after exposure to cyclophosphamide in vivo