Topical Tretinoin Improves Photoaged Skin: A Double-blind Vehicle-Controlled Study

JAMA: The Journal of the American Medical Association

Volumn 259, Issue 4, 1988, Pages 527-532

  Weiss, Jonathan S ^a   Ellis, Charles N ^a   Headington, John T ^a   Tincoff, Theresa ^a   Hamilton, Ted A ^a   Voorhees, John J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID;

ADULT; AGED; AGING; ARTICLE; BIOPSY; CLINICAL TRIAL; CONTACT DERMATITIS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SCREENING; FACE; FOREARM; HUMAN; INTRADERMAL DRUG ADMINISTRATION; PATHOLOGY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SKIN DISEASE; SKIN PIGMENTATION; SUNLIGHT;

ADMINISTRATION, CUTANEOUS; ADULT; AGED; AGING; BIOPSY; DERMATITIS, CONTACT; DOUBLE-BLIND METHOD; DRUG EVALUATION; FACE; FOREARM; HUMAN; MIDDLE AGE; RANDOM ALLOCATION; SKIN DISEASES; SKIN PIGMENTATION; SUNLIGHT; SUPPORT, NON-U.S. GOV'T; TRETINOIN;

EID: 0024294231     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1988.03720040019020     Document Type: Article

References (38)

1. Kligman LH, Kligman AM: Photoaging, in Fitzpatrick TB, Eisen AZ, Wolff K, et al. (eds): Dermatology in General Medicine, ed 3. New York, McGraw-Hill International Book Co, 1986, pp 1470-1475.
2. Fenske NA, Lober CW: Structural and functional changes of normal aging skin. J Am Acad Dermatol 1986;15:571-585.
3. Montagna W, Carlisle K: Structural changes in aging human skin. J Invest Dermatol 1979;73: 47-53.
4. Shuster S, Black MM, McVitie E: The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol 1975;93:639-643.
5. Kligman LH, Kligman AM: The nature of photoaging: Its prevention and repair. Photodermatol 1986;3:215-227.
6. Gillman T, Penn J, Bronks D, et al.: Abnormal elastic fibers. Arch Pathol Lab Med 1955;59: 733-749.
7. Smith JG, Davison EA, Sams WM, et al.: Alterations in human dermal connective tissue with age and chronic sun damage. J Invest Dermatol 1962;39:347-350.
8. Sams WM, Smith JG: The histochemistry of chronically sun-damaged skin. J Invest Dermatol 1961;37:447-452.
9. Gilchrest BA: Skin and Aging Processes. Boca Raton, Fla, CRC Press Inc, 1984, pp 97-98.
10. Kligman LH, Akin FJ, Kligman AM: The contributions of UVA and UVB to connective tissue damage in hairless mice. J Invest Dermatol 1985;84:272-276.
11. Kligman LH, Akin FJ, Kligman AM: Prevention of ultraviolet damage to the dermis of hairless mice by sunscreens. J Invest Dermatol 1982;78: 181-189.
12. Kligman LH: Photoaging: Manifestations, prevention and treatment. Dermatol Clin 1986;4: 517-528.
13. Kligman LH, Akin FJ, Kligman AM: Sunscreens promote repair of ultraviolet radiation-induced dermal damage. J Invest Dermatol 1983;81: 98-102.
14. Kligman LH, Duo CH, Kligman AM: Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue. Connect Tissue Res 1984;12:139-150.
15. Kligman LH: Effects of all-trans-retinoic acid on the dermis of hairless mice. J Am Acad Dermatol 1986;15:779-785.
16. Kligman AM, Grove GL, Hirose R, et al.: Topical tretinoin for photoaged skin. J Am Acad Dermatol 1986;15:836-859.
17. Elias PM, Williams ML: Retinoids, cancer and the skin. Arch Dermatol 1981;117:160-180.
18. Ellis CN, Gold RC, Grekin RC, et al.: Etretinate therapy stimulates deposition of a mucus-like material in epidermis of patients with psoriasis. J Am Acad Dermatol 1982;6:699-704.
19. Kanerva LO, Johansson E, Niemi K-M, et al.: Epidermodysplasia verruciformis: Clinical and light- and electron-microscopic observations during etretinate therapy. Arch Dermatol Res 1985;278: 153-160.
20. Orfanos CE, Runne U: Tissue changes in psoriatic plaques after oral administration of retinoid. Dermatologica 1978;157(suppl 1):19-25.
21. Piepkorn M, Fleckman P, Carney H, et al.: Glycosaminoglycan synthesis by proliferating and differentiated human keratinocytes in culture. J Invest Dermatol 1987;88:215-219.
22. Siegenthaler G, Saurat JH, Morin C, et al.: Cellular retinol- and retinoic acid—binding proteins in the epidermis and dermis of normal human skin. Br J Dermatol 1984;111:647-654.
23. Puhvel SM, Sakamoto M: Cellular retinoic acid—binding proteins in human epidermis and sebaceous follicles. J Invest Dermatol 1984;82: 79-84.
24. Chytil F: Retinoic acid: Biochemistry and metabolism. J Am Acad Dermatol 1986;15:741-747.
25. Sporn MB, Roberts AB: Role of retinoids in differentiation and carcinogenesis. Cancer Res 1983;43:3034-3040.
26. Elias PM: Epidermal effects of retinoids: Supramolecular observations and clinical implications. J Am Acad Dermatol 1986;15:797-809.
27. Oikarinen Al, Oikarinen H, Uitto J: Demonstration of cellular retinoic acid binding protein in cultured human skin fibroblasts. Br J Dermatol 1985;113:529-535.
28. Barranco VP, Olson RI, Everett MA: Response of actinic keratoses to vitamin A acid. Cutis 1970;6:681-685.
29. Bollag W, Ott F: Retinoic acid: Topical treatment of senile or actinic keratoses and basal cell carcinomas. Agents Actions 1970;1:1172-1175.
30. Schumacher A, Stuttgen G: Vitamin A—Säure bei Hyperkeratosen, epithelialen Tumoren und Akne. Dtsch Med Wochenschr 1971;40:1547-1551.
31. Robinson TA, Kligman AM: Treatment of solar keratoses of extremities with retinoic acid and 5-fluorouracil. Br J Dermatol 1975;92:703-706.
32. Epstein JH: All-trans-retinoic acid and cutaneous cancers. J Am Acad Dermatol 1986;15:772-778.
33. Bollag W: Prophylaxis of chemically induced benign and malignant epithelial tumors by retinoic acid. Eur J Cancer Clin Oncol 1972;8:689-693.
34. Model D: Smoker’s face: An underrated clinical sign? Br Med J Clin Res 1985;291:1760-1762.
35. Daniell HW: Smoker’s wrinkles: A study in the epidemiology of ’crow’s feet.’ Ann Intern Med 1971;75:873-880.
36. Ippen M, Ippen H: Approaches to prophylaxis of skin aging. J Soc Cosmetic Chemists 1965;16: 305-308.
37. Fritsch PO, Pohlin G, Langle V, et al.: Response of epidermal cell proliferation to orally administered aromatic retinoid. J Invest Dermatol 1981;77: 287-291.
38. Pinkus H, Hunter R: Biometric analysis of the effect of oral vitamin A on human epidermis. J Invest Dermatol 1964;42:131-136.