Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

Cell

Volumn 52, Issue 3, 1988, Pages 343-354

  Housey, Gerard M ^a   Johnson, Mark D ^a   Wendy Hsiao, W L ^a   O'Brian, Catherine A ^a   Murphy, James P ^a   Kirschmeier, Paul ^a   Bernard Weinstein, I ^a  

^a Comprehensive Cancer Centerand Institute Cancer Research College of Physicians Surgeons Columbia University New York ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PHORBOID RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL DIVISION; CELL LINE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; FIBROBLAST; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PHYSIOLOGY; RAT;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CELL DIVISION; CELL LINE; DNA; FIBROBLASTS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASE C; RATS; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC;

EID: 0024284828     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(88)80027-8     Document Type: Article

References (45)

1. The phorbol ester receptor a phospholipidregulated protein kinase
2. Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity
3. Effect of 12-O-tetradecanoylphorbol-13-acetate on the morphology and growth of C3H/10T1/2 mouse embryo cells
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
5. Distinct patterns of expression of different protein kinase C mRNAs in rat tissues
6. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signalling pathways
7. The CML-specific P210 bcr/abl protein, unlike v-abl does not transform NIH/3T3 fibroblasts
8. Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine 654
9. Morphological transformation of rat embryo cells induced by diethylnitrosamine and murine leukemia viruses
10. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium
11. A new technique for the assay of infectivity of human adenovirus DNA
12. src at a novel site
13. Identification of receptors for phorbol ester tumor promoters in intact mammalian cells and of an inhibitor of receptor binding in biologic fluids
14. Expression of long terminal repeat (LTR) sequences in carcinogen-induced murine skin carcinomas
15. Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family
16. Oncogene-induced transformation of a rat embryo fibroblast cell line is enhanced by tumor promoters
17. 2+-activated, phospholipid-dependent protein kinase
18. Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane
19. Purification and characterization of three types of protein kinase C from rabbit brain cytosol
20. Phosphorylation of ras oncogene product by protein kinase C
21. 2+-activated, phospholipid-dependent protein kinase
22. Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties
23. Cloning and expression of multiple protein kinase C cDNAs
24. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
25. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol
26. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
27. A cDNA encoding PKC identifies two species of mRNA in brain and GH3 cells
28. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus
29. The role of protein kinase C in cell surface transduction and tumour promotion
30. Studies and perspectives of protein kinase C
31. 2+ or aphorbol ester tumor promoter
32. Two types of complementary DNAs of rat brain protein kinase C
33. Expression and properties of two types of protein kinase C: alternative splicing from a single gene
34. Tissue-specific expression of three distinct types of rabbit protein kinase C
35. The complete primary structure of protein kinase C—the major phorbol ester receptor
36. Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol-12-myristate 13-acetate
37. Efficient detection of soft agar grown colonies using tetrazolium salt
38. Regulation of transmembrane signaling by receptor phosphorylation
39. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
40. A three-step purification procedure for protein kinase C: characterization of the purified enzyme
41. Growth factors, oncogenes, and multistage carcinogenesis
42. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells
43. Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognitionrequirements
44. Down-regulation of protein kinase C is due to an increased rate of degradation