Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

The Journal of biological chemistry

Volumn 263, Issue 16, 1988, Pages 7610-7619

  Hepler, J R ^a   Earp, H S ^a   Harden, T K ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANGIOTENSIN II; ARGIPRESSIN; EPIDERMAL GROWTH FACTOR; GROWTH PROMOTOR; HORMONE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL; PROTEIN KINASE C;

ANIMAL; ARTICLE; CELL LINE; DRUG POTENTIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; RAT; TIME;

ANGIOTENSIN II; ANIMALS; ARGININE VASOPRESSIN; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SYNERGISM; EPIDERMAL GROWTH FACTOR; EPINEPHRINE; GROWTH SUBSTANCES; HORMONES; PHOSPHATIDYLINOSITOLS; PROTEIN KINASE C; RATS; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 0024278658     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)