Synthesis and Antiherpetic Activity of (±)-9-[[(Z)-2-(Hydroxymethyl)Cyclopropyl]methyl]guanine and Related Compounds

Journal of Medicinal Chemistry

Volumn 31, Issue 12, 1988, Pages 2304-2315

  Ashton, Wallace T ^a   Canning Meurer, Laura ^a   Cantone, Christine L ^a   Kirk Field, A ^a   Hannah, John ^a   Karkas, John D ^a   Liou, Richard ^a   Patel, Gool F ^a   Perry, Helen C ^a   Wagner, Arthur F ^a   Walton, Edward ^a   Tolman, Richard L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 [2 (HYDROXYMETHYL)CYCLOPROPYLMETHYL]ADENINE; 9 [2 (HYDROXYMETHYL)CYCLOPROPYLMETHYL]GUANINE; ACICLOVIR; ACICLOVIR DERIVATIVE; DNA POLYMERASE; GANCICLOVIR; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL CULTURE; DRUG METABOLISM; DRUG SYNTHESIS; HELA CELL; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; RABBIT; STRUCTURE ACTIVITY RELATION;

ACYCLOVIR; ANIMAL; ANTIVIRAL AGENTS; CELLS, CULTURED; CHEMISTRY; COMPARATIVE STUDY; DNA-DIRECTED DNA POLYMERASE; GANCICLOVIR; PHOSPHORYLATION; SIMPLEXVIRUS; VIRUS REPLICATION;

EID: 0024262556     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00120a010     Document Type: Article

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