Preferential clonogenic deficit of cd8-positive t-lymphocytes infiltrating human solid tumors

Cancer Research

Volumn 48, Issue , 1988, Pages 6992-6998

  Miescher, Sylvia ^a   Stoeck, Michael ^a   Qiao, Liang ^a   Barras, Catherine ^a   Barrelet, Laurent ^a   Von Fliedner, Vladimir ^a  

^a POLICLINIQUE MÉDICALE UNIVERSITAIRE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN;

CELL CLONE; CELL CULTURE; CYTOCHEMISTRY; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; SOLID TUMOR; TUMOR ASSOCIATED LEUKOCYTE;

AGED; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL DIVISION; COMPARATIVE STUDY; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMAN; INTERLEUKIN-2; MALE; MIDDLE AGE; NEOPLASMS; PHENOTYPE; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0024246624     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Underwood, J. C. E. Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review. Br. J. Cancer, 30: 538–548, 1974.
2. Lauder, I., and Aherne, W. The significance of lymphocytic infiltration in neuroblastoma. Br. J. Cancer, 26:321-330, 1972.
3. Svennevig, J. L., Lunde, O. C., Holter, J., and Bjorgsvik, D. Lymphoid infiltration and prognosis in colorectal carcinoma. Br. J. Cancer, 49: 375-377, 1985.
4. Whiteside, T. L., Miescher, S., Hurlimann, J., Moretta, L., and von Fliedner, V. Separation, phenotyping and limiting dilution analysis of T-lymphocytes infiltrating human solid tumors. Int. J. Cancer, 37:803-811, 1986.
5. Miescher, S., Whiteside, T. L., Carrel, S., and von Fliedner, V. Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes. J. Immunol., 136:1899-1907, 1986.
6. Miescher, S., Whiteside, T. L., Moretta, L., and von Fliedner, V. Clonal and frequency analyses of tumor-infiltrating T lymphocytes from human solid tumors. J. Immunol., 138:4004-4011, 1987.
7. Moretta, A., Pantaleo, G., Moretta, L., Cerottini, J. C., and Mingari, M. C. Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity. J. Exp. Med., 157:743-754, 1983.
8. Moretta, A., Pantaleo, G., Moretta, L., Mingari, M. C., and Cerottini, J. C. Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations. J. Exp. Med., 158:571-585, 1983.
9. Weiss, A., Imboden, J., Shoback, D., and Stobo, J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc. Natl. Acad. Sci. USA, 81:4169-4173, 1984.
10. Meuer, S. C., Hussey, R. E., Fabbi, M., Fox, D., Acuto, O., Fitzgerald, K. A., Hodgdon, J. C., Protentis, J. P., Schlossman, S. F., and Reinherz, E. L. An alternative pathway of T-cell activation: a functional role for the 50 Kd T11 sheep erythrocyte receptor protein. Cell, 36:897-906, 1984.
11. Olive, D., Ragueneau, M., Cerdan, C., Dubreuil, P., Lopez, M., and Mawas, C. Anti-CD2 (sheep red blood cell receptor) antibodies and T cell activation. I. Pairs of anti-T11.1 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoyl phorbol 13-acetate. Eur. J. Immunol., 16: 1062-1068, 1986.
12. Weiss, A., Imboden, J., Hardy, K., Manger, B., Terhorst, C., and Stobo, J. The role of the T3/antigen receptor complex in T-cell activation. Ann. Rev. Immunol., 4:593-619, 1986.
13. Kanellopoulos, J. M., De Petris, S., Leca, G., and Crumpton, M. J. The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes. Eur. J. Immunol., 15:479-486, 1985.
14. Tax, W. J. M., Willems, H. W., Reekers, P. P. M., Capel, P. J. A., and Koene, R. A. P. Polymorphism in mitogenic effect of IgGl monoclonal antibodies against T3 antigen on human T cells. Nature (Lond.), 304:445-447, 1983.
15. Taswell, C. Limiting dilution assay for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol., 126:1614-1620, 1981.
16. Taswell, C., MacDonald, H. R., and Cerottini, J. C. Clonal analysis of cytolytic T lymphocyte specificity. I. Phenotypically distinct sets of clones as the cellular basis of cross-reactivity to alloantigens. J. Exp. Med. 151:1372-1385, 1980.
17. Moretta, A. Frequency and surface phenotype of human T lymphocytes producing interleukin-2. Analysis by limiting dilution and cell cloning. Eur. J. Immunol., 15:148-155, 1985.
18. Landegren, U. Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens. J. Immunol. Methods, 67:379-388, 1984.
19. Lanier, L. L., Le, A. M., Philipps, J. H., Warner, N. L., and Babcock, G. F. Subpopulations of human natural killer cells defined by the expression of the Leu-7 (HNK-1) and Leu 11 (NK 15) antigens. J. Immunol., 131:1789-1796, 1983.
20. Schmidt, R. E., Murray, C., Daley, J. F., Schlossman, S. F., and Ritz, J. A subset of natural killer cells in peripheral blood displays a mature T cell phenotype. J. Exp. Med., 164:351-356, 1986.
21. Ferrini, S., Miescher, S., Zocchi, M. R., von Fliedner, V., and Moretta, A. Phenotypic and functional characterization of recombinant interleukin-2 (rIL-2)-induced activated killer cells: analysis at the population and clonal levels. J. Immunol., 138:1297-1302, 1987.
22. Pilarski, L. M., Mant, M. J., Ruether, B. A., Carayanniotis, G., Otto, D., and Krowka, J. F. Abnormal clonogenic potential of T cells from multiple myeloma patients. Blood, 66:1266-1271, 1985.
23. Del Prete, G. F., Vercelli, D., Tin, A., Maggi, E., Mariotti, S., Pinchera, A., Ricci, M., and Romagnani, S. In vivo activated cytotoxic T cells in the thyroid infiltrate of patients with Hashimoto's thyroiditis. Clin. Exp. Immunol., 65:140-147, 1986.
24. Bergroth, V., Konttinen, Y. T., Nykanen, P., von Essen, R., and Koota, K. Proliferating cells in the synovial fluid in rheumatic disease. Scand. J. Immunol., 22:383-388, 1985.
25. Greenwood, J. H., Austin, L. L., and Dobbins, W. O. III. In vitro characterization of human intestinal intraepithelial lymphocytes. Gastroenterology, 85:1023-1035, 1983.
26. Ebert, E. C., Roberts, A. L., Brolin, R. E., and Raska, K. Examination of the low proliferative capacity of human jejunal intraepithelial lymphocytes. Clin. Exp. Immunol., 65:148-157, 1986.
27. Truneh, A., Albert, F., Golstein, P., and Schmitt-Verhulst, A. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature (Lond.), 313:318-320, 1985.
28. Landay, A., Gartland, G. L., and Clement, L. T. Characterization of a phenotypically distinct subpopulation of Leu-2+cells which suppresses T cell proliferative responses. J. Immunol., 131:2757-2761, 1983.
29. Clement, L. T., Dagg, M. K., and Landay, A. Characterization of human lymphocyte subpopulations: alloreactive cytotoxic T lymphocyte precursor and effector cells are phenotypically distinct from Leu-2+ suppressor cells. J. Clin. Immunol., 4:395-402, 1984.
30. Introna, A., Allavena, P., Biondi, A., Colombo, N., Villa, N., and Mantovani, A. Defective natural killer activity within human ovarian tumors: low numbers of morphologically defined effectors present in situ. J. Natl. Cancer Inst., 70:21-26, 1983.
31. Vose, B. M., and Moore, M. Human tumor-infiltrating lymphocytes: a marker of host response. Semin. Hematol., 22:27-40, 1985.
32. Whiteside, T. L., Miescher, S., Hurlimann, J., Moretta, L., and von Fliedner, V. Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas. Cancer Immunol. Immunother., 23: 169–178, 1986.
33. Moretta, L., Mingari, M. C., Sekaly, R. P., Moretta, A., Chapuis, B., and Cerottini, J. C. Surface markers of cloned human T cells with various cytolytic activities. J. Exp. Med., 154:569-574, 1981.
34. Anichini, A., Fossati, G., and Parmiani, G. Clonal analysis of the cytolytic T-cell response to human tumors. Immunol. Today, 8:385-389, 1987.
35. Reinherz, E. L., Meuer, S., Fitzgerald, K. A., Hussey, R. E., Levine, H., and Schlossmann, S. F. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell, 30:735-743, 1982.
36. Meuer, S. C., Fitzgerald, K. A., Hussey, R. E., Hodgdon, J. C., Schlossman, S. F., and Reinherz, E. L. Clonotypic structures involved in antigen-specific human T cell function. J. Exp. Med., 157:705-719, 1983.
37. Zanders, E., Lamb, J., Feldman, M., Green, N., and Beverely, P. Tolerance of T-cell clones is associated with membrane antigen changes. Nature (Lond.), 303:625-627, 1983.
38. Huang, Y. P., Miescher, P. A., and Zubler, R. H. The interleukin-2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells. J. Immunol., 137:3515-3520, 1986.