A model for the structure and functions of iron-responsive elements

Gene

Volumn 72, Issue 1-2, 1988, Pages 201-208

  Hentze, Matthias W ^a   Caughman, S Wright ^a   Casey, John L ^a   Kodier, David M ^a   Rouault, Tracey A ^a   Harford, Joe B ^a   Klausner, Richard D ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

evolution; Ferritin; gene regulation; iron metabolism; mRNA stability; mRNA structure; transferrin receptor; translation

Indexed keywords

FERRITIN; IRON; MESSENGER RNA; RADIOISOTOPE; TRANSFERRIN RECEPTOR;

ANIMAL CELL; COMPUTER ANALYSIS; EVOLUTION; GENE CONTROL; GENETIC ENGINEERING; HEREDITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA STRUCTURE; RNA TRANSLATION;

ANIMAL; BASE SEQUENCE; CHICKENS; COMPARATIVE STUDY; FERRITIN; GENE EXPRESSION REGULATION; GENES, STRUCTURAL; HUMAN; IRON; MACROMOLECULAR SYSTEMS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDE PROBES; RANA CATESBEIANA; RATS; RECEPTORS, TRANSFERRIN; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024246416     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(88)90145-X     Document Type: Article

References (30)

1. Both subunits of rat liver ferritin are regulated at a translational level by iron induction
2. Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region
3. Effect of iron chelators on the transferrin receptor in K562 cells
4. Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor
5. Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation
6. Isolation of cDNA and genomic clones for chicken transferrin receptor
7. Supercoil sequencing: a fast simple method for sequencing plasmid DNA
8. Structure of gene and pseudogenes of human apoferritin H
9. Multiple red cell ferritin mRNAs, which code for an abundant protein in the embryonic cell type, analyzed by cDNA sequence and by primer extension of the 5' untranslated regions
10. Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene
11. A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron
12. Identification of the iron-responsive element for the translational regulation of human ferritin mRNA
13. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes
14. Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family Conservation of sequences within noncoding regions of ferritin genes
15. Molecular Cloning
16. Biosynthetic regulation of the human transferrin receptor by desfemoxamine in K562 cells
17. Ferritin, structure, biosynthesis, and role in iron metabolism
18. Conservation of ferritin heavy subunit gene structure: Implications for the regulation of ferritin gene expression
19. Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency
20. Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells
21. Transcriptional regulation by iron of the gene for the transferrin receptor
22. Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus
23. Influence of altered transcription on the translational control of human ferritin expression
24. DNA sequencing with chain terminating inhibitors
25. Cloning of the gene coding for human L apoferritin
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27. Ferritin structure gene regulation and cellular function in animals plants and microorganisms
28. Regulation of HeLa cell transferrin receptors
29. Novel mechanism for translational control in regulation of ferritin synthesis by iron
30. Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information