Proliferative and cytolytic potentials of purified human tumor‐infiltrating t lymphocytes. Impaired response to mitogen‐driven stimulation despite T‐cell receptor expression

International Journal of Cancer

Volumn 42, Issue 5, 1988, Pages 659-666

  Miescher, S ^a   Stoeck, M ^a   Qiao, L ^a   Barras, C ^a   Barrelet, L ^a   von Fliedner, V ^a  

^a POLICLINIQUE MÉDICALE UNIVERSITAIRE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; MITOGENIC AGENT; T LYMPHOCYTE RECEPTOR;

HUMAN; HUMAN CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE;

ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL DIVISION; CELL SEPARATION; CELL SURVIVAL; ETHERS; HUMAN; INTERLEUKIN-2; IONOMYCIN; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES, CYTOTOXIC; TETRADECANOYLPHORBOL ACETATE;

EID: 0024245729     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910420504     Document Type: Article

References (33)

1. Clonal analysis of the cytolytic T‐Cell response to human tumors
2. Immunohistologic characterization of major histocompatibility antigens and inflammatory cellular infiltrate in human breast cancer
3. Identification of a putative second T‐Cell receptor
4. Characterization of cells from invaded lymph nodes in patients with solid tumors
5. Characterization of an immunosuppressive factor derived from colon cancer cells
6. Surface markers of human lymphokine‐Activated killer cells and their precursors. Analysis at the population and clonal level
7. Glycosphingolipids in cellular interaction, differentiation, and oncogenesis
8. Long‐Term interleukin 2‐Dependent growth and cytotoxic activity of tumor‐Infiltrating lymphocytes from human squamous‐Cell carcinomas of the head and neck
9. Production of transforming growth factor by human T lymphocytes and its potential role in the regulation of T cell growth
10. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus
11. The transforming growth factors
12. Functional properties of tumor‐Infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes
13. Clonal and frequency analyses of tumor‐Infiltrating T lymphocytes from human solid tumors
14. Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA‐DR expression and cytolytic activity
15. Depression of natural killer cytotoxic activity in lymphocytes infiltrating human pulmonary tumors
16. Regulation of cellular immune response against autologous human melanoma. I. Evidence for cell mediated suppression of in vitro cytotoxic immune response
17. Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma
18. In situ analysis of the mononuclear cell infiltrate in primary malignant melanoma of the skin
19. Inhibition of normal allogeneic lymphocyte mitogenesis by a soluble inhibitor extracted from human colonic carcinoma
20. High and low affinity receptors for interleukin‐2: implications of pronase, phorbol ester, and cell membrane studies upon the basis for differential ligand affinities
21. The suppressive effect of gangliosides upon IL‐2‐Dependent proliferation as a function of inhibition of IL‐2‐Receptor association
22. Transforming growth factors from neoplastic and non‐Neoplastic tissues
23. Observations on the systemic administration of autologous lymphokine‐Activated killer cells and recombinant interleukin‐2 to patients with metastatic cancer
24. Immunoregulatory factors derived from human tumors
25. Limiting dilution assay for the determinations of immunocompetent cell frequencies. I. Data analysis
26. Clonal analysis of cytolytic T lymphocyte specificity. I. Phenotypically distinct sets of clones as the cellular basis of cross‐Reactivity to alloantigens
27. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester
28. ‐ clones, regulated via CD3 and CD16 activation sites, recombinant interleukin 2 and interferon‐β
29. Human tumor infiltrating lymphocytes: a marker of host response
30. IL2 receptor induction on human T lymphocytes: role for IL2 and monocytes
31. Separation, phenotyping and limiting dilution analysis of T lymphocytes infiltrating human solid tumors
32. Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas
33. T‐Cell suppressor factor from human glioblastoma cells is a 12.5 Kd protein closely related to transforming growth factor‐β