Selective cytotoxic activity of immunotoxins composed of a monoclonal anti-thy 1.1 antibody and the ribosome-inactivating proteins bryodin and momordin

British Journal of Cancer

Volumn 58, Issue 5, 1988, Pages 558-561

  Stirpe, F ^a   Wawrzynczak, E J ^b   F Brown, A N ^b   Knyba, R E ^b   Watson, G J ^b   Barbieri, L ^a   Thorpe, P E ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; BRYODIN; MOMORDIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; CELL CULTURE; CONJUGATION; CYTOTOXICITY; LYMPHOMA CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIMETABOLITES, ANTINEOPLASTIC; IMMUNOTOXINS; ISOANTIBODIES; LYMPHOMA; MICE; PLANT PROTEINS; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0024244078     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1988.258     Document Type: Article

References (28)

1. BARBIERI, L. & STIRPE, F. (1982). Ribosome-inactivating proteins from plants: Properties and possible uses. Cancer Surveys, 1, 489.
2. BARBIERI, L., ZAMBONI, M., LORENZONI, E., MONTANARO, L., SPERTI, S. & STIRPE, F. (1980). Inhibition of protein synthesis in vitro by proteins from the seeds of Momordica charantia (bitter pear melon). Biochem. J., 186, 443.
3. BLAKEY, D.C. & THORPE, P.E. (1988). The prevention of carbohydrate-mediated clearance of ricin-containing immunotoxins by the liver. In Immunotoxins, Frankel, A. (ed) p. 457. Martinus Nijhoff Publishers: Boston.
4. BLAKEY, D.C., WATSON, G.J., KNOWLES, P.P. & THORPE, P.E. (1987a). Effect of chemical deglycosylation of ricin A-chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A-chain and anti-Thy 1.1 antibody. Cancer Res. 47, 947.
5. BLAKEY, D.C., WAWRZYNCZAK, E.J., STIRPE, F. & THORPE, P.E. (1987b). Anti-tumour activity of a panel of anti-Thy 1.1 immunotoxins made with different ribosome-inactivating proteins. In Membrane-Mediated Cytotoxicity, Bonavida, B. & Collier, R.J. (eds) p. 195. Alan R. Liss: New York.
6. BLYTHMAN, H.E., CASELLAS, P., GROS, O. & 5 others (1981). Immunotoxins: Hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells. Nature, 290, 145.
7. COLOMBATTI, M., NABHOLZ, M., GROS, O. & BRON, C. (1983). Selective killing of target cells by antibody-ricin A chain or antibody-gelonin hybrid molecules: Comparison of cytotoxic potency and use in immunoselection procedures. J. Immunol., 131, 3091.
8. FALASCA, A., GASPERI-CAMPANI, A., ABBONDANZA, A., BARBIERI, L. & STIRPE, F. (1982). Properties of the ribosomeinactivating proteins gelonin, Momordica charantia inhibitor, and dianthins. Biochem. J., 207, 505.
9. GLENNIE, M.J., MCBRIDE, H.M., STIRPE, F., THORPE, P.E., WORTH, A.T. & STEVENSON, G.T. (1987). Emergence of immunoglobulin variants following treatment of a B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin. J. Exp. Med., 166, 43.
10. LAMBERT, J.M., SENTER, P.D., YAU-YOUNG, A., BLATTLER, W.A. & GOLDMACHER, V.S. (1985). Purified immunotoxins that are reactive with human lymphoid cells. J. Biol. Chem., 260, 12035.
11. LETVIN, N.L., GOLDMACHER, V.S., RITZ, J., YETZ, J.M., SCHLOSSMAN, S.F. & LAMBERT, J.M. (1986). In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates. J. Clin. Invest., 77, 977.
12. MASON, D.W. & WILLIAMS, A.F. (1980). The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem. J., 187, 1.
13. MASUHO, M., KISHIDA, K. & HARA, T. (1982). Targeting of the antiviral protein from Phytolacca americana with an antibody. Biochem. Biophys. Res. Commun., 105, 462.
14. RAMAKRISHNAN, S. & HOUSTON, L.L. (1984a). Comparison of the selective cytotoxic effects of immunotoxins containing ricin A chain or pokeweed antiviral protein and anti-Thy 1.1 monoclonal antibodies. Cancer Res., 44, 201.
15. RAMAKRISHNAN, S. & HOUSTON, L.L. (1984b). Prevention of growth of leukemia cells in mice by monoclonal antibodies directed against Thy 1.1 antigen disulfide linked to two ribosomal inhibitors: Pokeweed antiviral protein or ricin A chain. Cancer Res., 44, 1398.
16. RAMAKRISHNAN, S. & HOUSTON, L.L. (1985). Immunological and biological stability of immunotoxins in vivo as studied by the clearance of disulfide-linked pokeweed antiviral protein-antibody conjugates from blood. Cancer Res., 45, 2031.
17. SCOTT, C.F., Jr., GOLDMACHER, V.S., LAMBERT, J.M., JACKSON, J.V. & McINTYRE, G.D. (1987a). An immunotoxin composed of a monoclonal antitransferrin receptor antibody linked by a disulfide bond to the ribosome-inactivating protein gelonin: Potent in vitro and in vivo effects against human tumors. J. Nail Cancer Inst., 79, 1163.
18. SCOTT, C.F., Jr., LAMBERT, J.M., GOLDMACHER, V.S. & 4 others (1987b). The pharmacokinetics and toxicity of murine monoclonal antibodies and of gelonin conjugates of these antibodies. Int. J. Immunopharmac., 9, 211.
19. SIVAM, G., PEARSON, J.W., BOHN, W., OLDHAM, R.K., SADOFF, J.C. & MORGAN, A.C. JR. (1987). Immunotoxins to a human melanoma-associated antigen: Comparison of gelonin with ricin and other A chain conjugates. Cancer Res., 47, 3169.
20. STIRPE, F., BAILEY, S., MILLER, S.P. & BODLEY, J.W. (1988). Modification of ribosomal RNA by ribosome-inactivating proteins from plants. Nucl. Acids Res., 16, 1349.
21. STIRPE, F. & BARBIERI, L. (1986). Ribosome-inactivating proteins up to date. FEBS Lett., 195, 1.
22. STIRPE, F., BARBIERI, L., BATTELLI, M.G. & 4 others (1986). Bryodin, a ribosome-inactivating protein from the roots of Bryonia dioica L. (white bryony). Biochem. J., 240, 659.
23. THORPE, P.E., BLAKEY, D.C., BROWN, A.N.F. & 5 others (1987). Comparison of two anti-Thy 1.1-abrin A chain immunotoxins prepared with different cross-linking agents: Antitumor effects, in vivo fate, and tumor cell mutants. J. Natl Cancer Inst., 79, 1101.
24. THORPE, P.E., BROWN, A.N.F., BREMNER, J.A.G., Jr., FOXWELL, B.M.J. & STIRPE, F. (1985). An immunotoxin composed of monoclonal anti-Thy 1.1 antibody and a ribosome-inactivating protein from Saponaria officinalis: Potent antitumor effects in vitro and in vivo. J. Natl Cancer Inst., 75, 151.
25. THORPE, P.E., BROWN, A.N.F., ROSS, W.C.J. & 5 others (1981). Cytotoxicity acquired by conjugation of an anti-Thy 1.1 monoclonal antibody and the ribosome-inactivating protein, gelonin. Eur. J. Biochem., 116, 447.
26. UCKUN, F.M., RAMAKRISHNAN, S. & HOUSTON, L.L. (1985). Increased efficiency in selective elimination of leukemia cells by a combination of a stable derivative of cyclophosphamide and a human B-cell specific immunotoxin containing pokeweed antiviral protein. Cancer Res., 45, 69.
27. WAWRZYNCZAK, E.J. & THORPE, P.E. (1988). Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins. In Immunotoxins, Frankel, A. (ed) p. 239, Martinus Nijhoff Publishers: Boston.
28. WIELS, J., JUNQUA, S., DUJARDIN, P., LE PECQ, J.B. & TURSZ, T. (1984). Properties of immunotoxins against a glycolipid antigen associated with Burkitt's lymphoma. Cancer Res., 44, 129.