Methods for Drug Discovery: Development of Potent, Selective, Orally Effective Cholecystokinin Antagoniststs

Journal of Medicinal Chemistry

Volumn 31, Issue 12, 1988, Pages 2235-2246

  Evans, B E ^a   Rittle, K E ^a   Bock, M G ^a   DiPardo, R M ^a   Freidinger, R M ^a   Whitter, W L ^a   Lundell, G F ^a   Veber, D F ^a   Anderson, P S ^a   Chang, R S L ^a   Lotti, V J ^a   Cerino, D J ^a   Chen, T B ^a   Kling, P J ^a   Kunkel, K A ^a   Springer, J P ^a   Hirshfield, J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 5 PHENYL 1,4 BENZODIAZEPIN 2 ONE DERIVATIVE; 4 BROMO N (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL)BENZAMIDE; BENZODIAZEPINE RECEPTOR; CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR; CLONAZEPAM; DEVAZEPIDE; DIAZEPAM; FLUNITRAZEPAM; GASTRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG SYNTHESIS; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PANCREAS; RAT; STOMACH EMPTYING; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMAL; BENZODIAZEPINES; CHEMISTRY; CHOLECYSTOKININ; DRUG DESIGN; MICE; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0024239320     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00120a002     Document Type: Article

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