Molecular genetics of group I introns: RNA structures and protein factors required for splicing - a review

Gene

Volumn 73, Issue 2, 1988, Pages 273-294

  Burke, John M ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Intervening sequences; maturase; ribonucleoprotein; ribozyme; RNA structure; self splicing RNA

Indexed keywords

RIBONUCLEOPROTEIN;

GENETIC ENGINEERING; HEREDITY; INTRON; MICROORGANISM; NONHUMAN; NORMAL VALUE; PRIORITY JOURNAL; REVIEW; RNA SPLICING; RNA STRUCTURE;

INTRONS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; RNA SPLICING; RNA, CATALYTIC; RNA, RIBOSOMAL; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024217621     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(88)90493-3     Document Type: Article

References (96)

1. Functional domains m introns: trans-acting and cis-acting regions in intron 4 of the cob gene
2. A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof
3. A mitochondrial mRNA maturase gene transferred to the yeast nucleus can control mitochondrial mRNA splicing
4. Efficient splicing of two yeast mitochondrial introns controlled by a nuclear-encoded maturase
5. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity
6. Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure
7. One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity
8. Selection ofcircularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence
9. Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity
10. Genetic delineation of functional components of the group I intron in the phage T4 td gene
11. Towards defining the minimal structural requirements for self-splicing of the phage T4 td intron
12. Intron within the large RNA gene of N. crassa mitochondria: a long open reading frame and a consensus sequence possibly important in splicing
13. Role of conserved sequence elements 9L and 2 in selfsplicing of the Tetrahymena ribosomal RNA precursor
14. Structural conventions for group I introns
15. The chemistry of self-splicing RNA and RNA enzymes
16. Conserved sequences and structures of group I introns: building an active site for RNA catalysis—a review
17. Biological catalysis by RNA
18. In vitro splicing of rRNA precursor in Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence
19. Secondary structure of the Tetrahymena rRNA IVS: structural homology with fungal mitochondrial intervening sequences
20. Activation of a cryptic 5' splice site in the upstream exon of the phage T4 td gene: missplicing and mRNA deletion in a fidelity mutant
21. Universal code equivalent of a yeast mitochondrial intron reading frame is expressed into E. coli as a specific double strand endonuclease
22. RNA splicing in Neurospora mitochondria. Defective splicing of mitochondrial mRNA precursors in the nuclear mutant cyt18-1
23. Making ends meet: a model for RNA splicing in fungal mitochondria
24. Internal guide sequence and reaction specificity of group I self-splicing introns
25. Critical sequences within mitochondrial introns: pleiotropic mRNA maturase and cis-dominant signals of the box intron controlling reductase and oxidase
26. Genetic dissection of an RNA enzyme
27. Single base substitution in an intron of oxidase gene compensates splicing defects of the cytochrome b gene
28. Sequence of the intron and flanking exons of the mitochondrial 21S rRNA gene of yeast strains having different alleles at the omega and rib-1 loci
29. Mitochondrial genetics and functions
30. Organization of the mitochondrial 21S rRNA gene in Saccharomyces cerevisiae: mutant of the peptidyl transferase centre and nature of the omega locus
31. Mitochondrial introns as mobile genetic elements: the role of intron-encoded proteins
32. Analysis of a yeast nuclear gene involved in the maturation of mitochondrial pre-messenger RNA of the cytochrome oxidase subunit I
33. In vitro splicing of the terminal intervening sequence of Saccharomyces cerevisiae cytochrome b pre-mRNA
34. A-splicing of introns in the gene: a general way of reverting intron mutations
35. RNA splicing in Neurospora mitochondria: self-splicing of a mitochondrial intron in vitro
36. Protein-dependent splicing of a group I intron in ribonucleoprotein particles and soluble fractions
37. RNA splicing in Neurospora mitochondria: nuclear mutants defective in both splicing and 3' end synthesis of the large rRNA
38. Mechanism of recognition of the 5' splice site in self-splicing group I introns
39. Long range control circuits within mitochondria and between nucleus and mitochondria, II. Genetic and biochemical analyses of suppressors which selectively alleviate the mitochondrial intron mutations
40. RNA Splicing in Yeast Mitochondria: Genetic and Molecular Studies of the Folded Structures of Two Introns of the Cytochrome b Gene
41. Two domains for splicing in the intron of the phage T4 td gene established by non-directed mutagenesis
42. The NAM2 proteins from S. cerevisiae and S. douglasii are mitochondrial leucyl-tRNA synthetases, and are involved in mRNA splicing
43. Suppressor mutations identify box9 as a central nucleotide sequence in the highly ordered structure of intron RNA in yeast mitochondria
44. Cob intron 3 in yeast mtDNA: Nucleotide sequence and mutations in a novel RNA domain
45. Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons
46. New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of RNA self-splicing
47. The intron of the mitochondrial 21S rRNA gene: distribution in different yeast species and sequence comparison between Kluyveromyces thermotolerans and Saccharomyces cerevisiae
48. An intron-encoded protein is active in a gene conversion process that spreads an intron into a mitochondrial gene
49. Structure of the catalytic core of the Tetrahymena ribozyme as demonstrated by reactive abbreviated forms of the molecule
50. Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena
51. Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae
52. A yeast nuclear gene, MRS1, involved in mitochondrial RNA splicing: nucleotide sequence and mutational analysis of two overlapping reading frames on opposite strands
53. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena
54. Construction of novel cytochrome b genes in yeast mitochondria by subtraction or addition of introns
55. The yeast nuclear gene NAM2 is essential for mitochondrial DNA integrity and can cure a mitochondrial RNA-maturase deficiency
56. Three supressor mutations which cure a mitochondrial RNA maturase deficiency occur at the same codon in the open reading frame of the nuclear NAM2 gene
57. Functional domains in introns: RNA processing intermediates in cis and trans-acting mutants in the penultimate intron of the mitochondrial gene for cytochrome b
58. Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron
59. Transposition of an intron in yeast mitochondria requires a protein encoded by that intron
60. Defective splicing of mitochondrial rRNA in cytochrome-deficient nuclear mutants of Neurospora crassa.
61. An additional class II intron with homology to reverse transcriptase in rapidly senescing Podospora anserina
62. Assembly of the mitochondrial membrane system. Characterization of a yeast nuclear gene involved in the processing of the cytochrome b pre-mRNA
63. DNA splicing of mitochondrial group I and group II introns in Schizosaccharomyces pombe
64. Analysis of class I introns in a mitochondrial plasmid associated with senescence of Podospora anserina reveals extraordinary resemblance to the Tetrahymena ribosomal intron
65. Conservation of RNA secondary structures in two intron families including mitochondrial-, chloroplast- and nuclear-encoded members
66. Mitochondrial class II introns encode proteins related to the reverse transcriptases of retroviruses
67. Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure
68. Three class-I introns in the ND4L, ND5 transcriptional unit of Neurospora crassa mitochondria
69. Critical sequences within mitochondrial introns: Cis-dominant mutations of the ‘cytochrome-b-like’ intron of the oxidase gene
70. Sequence comparisons of the rDNA introns from six different species of Tetrahymena
71. Autocatalytic activities of intron 5 of the cob gene of yeast mitochondria
72. Variable occurrence of the nrdB intron in the T-even phages suggests intron mobility
73. Role of the 5' hairpin structure in the splicing accuracy of the fourth intron of the yeast cob-box gene
74. Coupling of Tetrahymena ribosomal RNA splicing to β-galactosidase expression in E. coli
75. Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA.
76. Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA
77. 5' exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5' splice site in the 3' exon
78. Role of the protein moiety of ribonuclease P, a ribonucleoprotein enzyme
79. COB intron 1 and 4: Studies on mutants and revertants uncover functional intron domains and test the validity of predicted RNA secondary structures
80. Pathways of transcript splicing in yeast mitochondria. Mutations in intervening sequences of the split gene cob reveal requirement for intervening sequenceencoded products
81. Construction of a yeast strain devoid of mitochondrial introns and its use to screen nuclear genes involved in mitochondrial splicing.
82. MSS18, a yeast nuclear gene involved in the splicing of intron aI5 beta of the mitochondrial cox1 transcript.
83. Steps in processing of the mitochondrial cytochrome oxidase subunit I pre-mRNA affected by a nuclear mutation in yeast
84. Phylogenetic evidence for the acquisition of ribosomal RNA introns subsequent to the divergence of some of the major Tetrahymena groups
85. A DNA polymerase activity with characteristics of a reverse transcriptase in Podospora anserina
86. Enzymatic activity of the conserved core of a group I self-splicing intron
87. The mosaic cox1 gene in the mitochondrial genome of Schizosaccharomyces pombe: minimal structural requirements and evolution of group-I introns
88. Assessment of a model for intron RNA secondary structure relevant to RNA selfsplicing—a review
89. Close relationship between certain nuclear and mitochondrial introns. Implications for the mechanism of RNA splicing
90. The Tetrahymena rRNA intron self-splices in E. coli: in vivo evidence for the importance of key base-paired regions of RNA for RNA enzyme function
91. Splice-site selection by a self-splicing RNA of Tetrahymena
92. Expression of the split gene cob in yeast: evidence for a precursor of a ‘maturase’ protein translated from intron 4 and preceding exons
93. Processing of yeast mitochondrial RNA: involvement of intramolecular hybrids in splicing of cob 14 RNA by mutation and reversion
94. Site-directed mutagenesis of core sequence elements 9R, 9L, 9R and 2 in self-splicing Tetrahymena pre-rRNA
95. Autocatalytic cyclization of an excised IVS RNA is a cleavage-ligation reaction
96. Nonreciprocal exchange between alleles of the yeast mitochondrial 21S rRNA gene: kinetics and the involvement of a double-strand break