The nature and kinetics of a delayed immune response to purified protein derivative of tuberculin in the skin of lepromatous leprosy patients

Journal of Experimental Medicine

Volumn 168, Issue 5, 1988, Pages 1811-1824

  Kaplan, Gilla ^a   Laal, Suman ^b   Sheftel, Giulia ^a   Nusrat, Asma ^a   Nath, Indira ^b   Mathur, N K ^c   Mishra, R S ^d   Cohn, Zanvil A ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c SSMS Medical College ^*  (India)

^d SAFDARJUNG HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

TUBERCULIN;

BIOLOGICAL MODEL; CLINICAL ARTICLE; EPIDERMIS; HISTOLOGY; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOLOGY; LEPROSY; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; SENSITIZATION; SKIN TEST; T LYMPHOCYTE;

GRANULOMA; HUMAN; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; LEPROSY; MACROPHAGES; MICROSCOPY, ELECTRON; MYCOBACTERIUM LEPRAE; PERIPHERAL NERVES; SKIN; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; TIME FACTORS; TUBERCULIN;

EID: 0024211454     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.168.5.1811     Document Type: Article

References (31)

1. Hansen, G. A. 1874. Undersogelser Angaende Spedalskhedens arsager. Nor. Mag. Laegevidensk. 4:1.
2. Godal, T. 1978. Immunological aspects of leprosy-present status. Prog. Allergy. 25:211.
3. Kaplan, G., M. D. Witmer, I. Nath, R. M. Steinman, S. Laal, H. Krishna Prasad, E. N. Sarno, U. Elvers, and Z. A. Cohn. 1986. Influence ofdelayed immune reactions on human epidermal keratinocytes. Proc. Natl. Acad Sci. USA. 83:3469.
4. Kaplan, G., A. D. Luster, G. Hancock, and Z. A. Cohn. 1987. The expression of a y interferon-induced protein (IP-10) in delayed immune responses in human skin. J. Exp. Med. 166:1098.
5. Kaplan, G., A. Nusrat, M. D. Witmer, I. Nath, and Z. A. Cohn. 1987. Distributio nand turnover of Langerhans cells during delayed immune responses in human skin. J. Exp. Med. 165:763.
6. Kaplan, G., G. Sheftel, C. K. Job, N. K. Mathur, I. Nath, and Z. A. Cohn. Efficacy of a cell mediated reaction to PPD in the disposal ofM. leprae from human skin. Proc. Natl. Acad. Sci. USA. 85:5210.
7. Ridley, D., and W. Jopling. 1966. Classification of leprosy according to immunity: A five-group system. Int. J. Lepr. 34:255.
8. Ridley, D. S., and G. R. F. Hilson. 1967. A logarithmic index of bacilli in biopsies. I. Method. Int. J Lepr 35:184.
9. Ridley, D. S. 1967. A logarithmic index of bacilli in biopsies. II. Evaluation. Int.J. Lepr. 35:187.
10. McLean, I. W., and P. K. Nakane. 1974. Periodate-lysine-paraformaldehyde fixative:a new fixative for immunoelectron microscopy. J Histochem. Cytochem. 22:1077.
11. Engleman, E. G., R. Warnke, R. I. Fox, and R. Levy. 1981. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. Proc. Natl. Acad. Sci. USA. 78:1791.
12. Evans, R. L., D. W. Wall, C. D. Platsoucas, E. P. Siegal, S. M. Fikrig, C. M. Testa, and R. A. Good. 1981. Thymus-dependent membrane antigens in man: inhibition of cell mediated lympholysis by monoclonal antibodies to the TH2 antigen. Proc. Natl. Acad. Sci. USA. 78:544.
13. Schwarting, R., H. Stein, and C. Y. Wang. 1985. The monoclonal antibodies antis-HCl-1 and anti-S-HCl-3 allow the diagnosis of hair cell leukemia. Blood. 65:974.
14. Van Voorhis, W. C., G. Kaplan, E. N. Sarno, M. A. Horwitz, R. M. Steinman, W. R. Levis, N. Nogueira, L. R. Hair, C. R. Gattas, B. A. Arrick, and Z. A. Cohn. 1982. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant Tcell phenotypes. N. Engl. J. Med. 307:1593.
15. McInnes, A., and D. M. Rennick. 1988. IL- 4 induces culture monocytes/macrophages to form giant multinucleated cells. J. Exp. Med. 167:598.
16. Kaplan, G., W. C. Van Voorhis, E. N. Sarno, N. Norgueira, and Z. A. Cohn. 1983. The cutaneous infiltrates of leprosy. A transmission electron microscopy study. J Exp. Med. 158:1145.
17. Turk, J. L. 1980. Delayed hypersensitivity. In Research Monographs in Immunology. Vol. 1, 3rd edition. Elsevier Science Publishing Co., Inc., New York.
18. Bullock, W. E. 1968. Studies of immune mechanisms in leprosy. N. Engl.J. Med. 278:298.
19. Waldorf, D. S., J. N. Sheagren, J. R. Trautman, andJ. B. Block. 1966. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. ii:773.
20. Cree, I. A.,. C. S. Smith, R. J. W. Rees, and J. S. Beck. 1988. The influence of antimycobacterial chemotherapy on delayed hypersensitivity skin-test reaction in leprosy patients. Lepr. Rev. 59:145.
21. Van Loveren, H., R. Meade, and P. W. Askenase. 1983. An early component of delayedtype hypersensitivity mediated by T cells and mast cells. J. Exp. Med. 157:1604.
22. Turk, J. L. 1967. Response of lymphocytes to antigens. Transplantation (Baltimore). 5:952.
23. Macher, E., and M. W. Chase. 1969, Studies on the sensitization of animals with simple chemical compounds. XII. The influence of excision of allergenic depots on onset of delayed hypersensitivity and tolerance. J. Exp. Med. 169:103.
24. Van Oers, M. H. J., J. Pinkster, and W. P. Zeijlemaker. 1978. Quantification of antigenreactive cells among human T lymphocytes. Eur. J. Immunol. 8:477.
25. Nathan, C. F., G. Kaplan, W. R. Levis, A. Nusrat, M. D. Witmer, S. A. Sherwin, C. K. Job, C. R. Horowitz, R. M. Steinman, and Z. A. Cohn. 1986. Local and systemic effect of low doses of recombinant interferon-7 after intradermal injection in patients with lepromatous leprosy. N. Engl. J. Med. 315:6.
26. Kaplan, G., A. Nusrat, E. N. Sarno, C. K. Job, J. McElrath, J. A. Porto, C. F. Nathan, and Z. A. Cohn. 1987. Cellular responses to the intradermal injection of recombinant human y-interferon in lepromatous leprosy patients. Am. J Path. 128:345.
27. Lepay, D. A., R. M. Steinman, C. F. Nathan, H. W. Murray, and Z. A. Cohn. 1985. Live r macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. J Exp. Med. 161:1503.
28. Nakagawara, A., C. R Nathan, and Z. A. Cohn. 1981. Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin. Invest. 68:1243.
29. McElrath, J., H. W. Murray, and Z. A. Cohn. 1988. The dynamics ofgranuloma formation in experimental visceral leishmaniasis. J. Exp. Med. In press.
30. Ridley, D. S. 1969. Reactions in leprosy. Lepr. Rev. 40:77.
31. Jolliffe, D. S. 1977. Leprosy reactional states and their treatment. Br.J. Dermatol. 97:345.