The base-alteration spectrum of spontaneous and ultraviolet radiation-induced forward mutations in the URA3 locus of Saccharomyces cerevisiae

MGG Molecular & General Genetics

Volumn 214, Issue 3, 1988, Pages 396-404

  Lee, Grace S F ^a   Savage, Elizabeth A ^a   Ritzel, R Gary ^a   von Borstel, R C ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

"A rule"; Cyclobutane dimer; Pyrimidine pyrimidone (6 4) photoproduct; Saccharomyces cerevisiae; URA3 locus

Indexed keywords

CYCLOBUTANE;

FORWARD MUTATION; FUNGUS; GENE LOCUS; HEREDITY; METHODOLOGY; NONHUMAN; NUCLEOTIDE BASE; SACCHAROMYCES CEREVISIAE; SPONTANEOUS MUTATION; ULTRAVIOLET RADIATION;

ADENINE; BASE SEQUENCE; CYCLOBUTANES; DNA MUTATIONAL ANALYSIS; DNA, FUNGAL; GENES, FUNGAL; GENETIC VECTORS; OROTIC ACID; PLASMIDS; PYRIMIDINE DIMERS; SACCHAROMYCES CEREVISIAE; SUPPORT, NON-U.S. GOV'T; ULTRAVIOLET RAYS;

EID: 0024203273     PISSN: 00268925     EISSN: 16174623     Source Type: Journal    
DOI: 10.1007/BF00330472     Document Type: Article

References (65)

1. Efficient recovery and sequencing of mutant genes from mammalian chromosomal DNA
2. Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination
3. A rapid alkaline extraction procedure for screening recombinant plasmid DNA
4. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
5. Construction and characterization of new cloning vehicles-II. A multipurpose cloning system
6. Distribution of ultraviolet-induced lesions in Simian Virus 40 DNA
7. A complementation analysis of the restriction and modification of DNA in Escherichia coli
8. UV-induced mutation hotspots occur at DNA damage hotspots
9. Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells
10. Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells
11. DNA sequence analysis of mutagenic site specificity of EMS in wild type and uvrB- strains of Escherichia coli
12. Genetic and sequence analysis of frameshift mutations induced by ICR-191
13. Supercoil sequencing: A fast and simple method for sequencing plasmid DNA
14. Rapid DNA isolations for enzymatic and hybridization analysis
15. The role of the (6-4) photoproduct in ultraviolet light-induced transition mutations in E. coli
16. Alkaline lability of fluorescent photoproducts produced in ultraviolet light-irradiated DNA
17. Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae
18. DNA sequence analysis of spontaneous mutations in the SUP4-o gene of Saccharomyces cerevisiae
19. Detection and analysis of UV-induced mutations in mammalian cell DNA using a phage shuttle vector
20. The C−C (6-4) UV photoproduct is mutagenic in Escherichia coli
21. Ultraviolet light repair and mutagenesis revisited
22. Sequence specificity of point mutations induced during passage of a UV-irradiated shuttle vector plasmid in monkey cells
23. Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae
24. Plasmid rescue — a tool for reproducible recovery of genes from transfected mammalian cells?
25. The mutational potential of unexcised pyrimidine dimers in Saccharomyces cerevisiae, RAD1-1. Evidence from photoreactivation and pedigree analysis
26. Mutational specificity of depurination
27. DNA sequence analysis of the mutational specificity of UV light in the SUP4-o gene of yeast
28. Absence of relationship between UV-induced reversion frequency and nucleotide sequence at the CYC-1 locus of yeast
29. Identity of the photoproduct that causes lacI mutations in UV-irradiated Escherichia coli
30. Sequence analysis of ultraviolet-induced mutations in M13 lacZ hybrid phage
31. Distribution of UV light induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences
32. Mutagenesis by apurinic/apyrimidinic sites
33. Plasmid-transformed URA3 FUR1 double-mutants of S. cerevisiae: an autoselection applicable to the production of foreign proteins
34. Different rates of spontaneous mutation during mitosis and meiosis in yeast
35. Mutagenic specificity of ultraviolet light
36. DNA repair in yeast: Genetic control and biological consequences
37. Near-UV photolysis of pyrimidine heteroadducts in E. coli DNA
38. Development of a yeast system to assay mutational specificity
39. UV-light induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells
40. The origin of spontaneous mutation in Saccharomyces cerevisiae
41. A photoreactivationless mutant of Saccharomyces cerevisiae
42. Structure and function of the yeast URA3 gene: expression in Escherichia coli
43. Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides
44. DNA sequencing with chain-terminating inhibitors
45. Role of depurination in mutagenesis by chemical carcinogens
46. Mutagenesis resulting from depurination in an SOS process
47. Infidelity of DNA synthesis associated with bypass of apurinic sites
48. Mechanisms of ultraviolet-induced mutation: mutational spectra in the Escherichia coli lacI gene for a wild-type and an excision-repair-deficient strain
49. Spontaneous mutability in yeast. I. Stability of lysine reversion rates to variation of adenine concentration
50. Cyclobutane-type pyrimidine dimers in polynucleotides
51. Inducibility of error-prone DNA repair in yeast
52. Frameshift mutagenesis of lambda prophage by 9-aminoacridine, proflavin and ICR-191
53. The role of DNA polymerase in base substitution mutagenesis on non-instructional templates
54. A mechanism of UV-reactivation
55. Ultraviolet irradiation of DNA in vitro and in vivo produces a third thymine-derived product
56. Effects of radiation on cells
57. Situation-dependent repair of DNA damage in yeast
58. Base sequence alterations induced by ultraviolet radiation in the URA3 locus in yeast
59. Inheritance of spontaneous mutability in yeast
60. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli
61. Pyrimidine dimers are not the principal premutagenic lesions induced in lambda DNA by ultraviolet light
62. Changes in DNA base sequence induced by targeted mutagenesis of lambda phage by ultraviolet light
63. Disappearance of thymine photodimer in ultraviolet irradiated DNA upon treatment with a photoreactivity enzyme from Baker's yeast