Reference dose (RfD): Description and use in health risk assessments

Regulatory Toxicology and Pharmacology

Volumn 8, Issue 4, 1988, Pages 471-486

  Barnes, Donald G ^a,b   Dourson, Michael ^a,b   Preuss, Peter ^b   Bellin, Judith ^b   Derosa, Christopher ^b   Engler, Reto ^b   Erdreich, Linda ^b   Farber, Theodore ^b   Fenner Crisp, Penny ^b   Francis, Elaine ^b   Ghali, George ^b   Hill, Richard ^b   Irene, Stephanie ^b   Marcus, William ^b   Patrick, David ^b   Perlin, Susan ^b   Revesz, Aggie ^b   Rubenstein, Reva ^b   Stara, Jerry ^b   Wiltse, Jeanette ^b   Zaragosa, Larry ^b   more..

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b Office of Research and Development United States Environmental Protection Agency ^*

Author keywords

[No Author keywords available]

Indexed keywords

TOXIC SUBSTANCE; XENOBIOTIC AGENT;

HUMAN; RISK ASSESSMENT; RISK MANAGEMENT;

ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; REFERENCE STANDARDS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 0024202909     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/0273-2300(88)90047-5     Document Type: Article

References (4)

1. Regulatory history and experimental support of uncertainty (safety) factors
2. 100-Fold margin of safety
3. Risk assessment guidelines for carcinogenicity, mutagenicity, complex mixtures, suspect developmental toxicants, and estimating exposures