Dopamine-containing neurons in the mammalian central nervous system: Electrophysiology and pharmacology

Neuroscience and Biobehavioral Reviews

Volumn 12, Issue 1, 1988, Pages 49-91

  Chiodo, Louis A ^a  

^a Sinai Research Institute   (United States)

Author keywords

Dopamine agonists; Dopamine antagonists; Dopamine neurons; Electrophysiology

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3 [4 (1,2,3,6 TETRAHYDRO 4 PHENYL 1 PYRIDYL)BUTYL]INDOLE; 4,7 DIMETHOXY N,N DIPROPYL 2 INDANAMINE; 9 OXAERGOLINE; APOMORPHINE; BROMOCRIPTINE; CHOLECYSTOKININ; CLONIDINE; DEXAMPHETAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; ESTROGEN; HALOPERIDOL; LISURIDE; LYSERGIDE; NEUROLEPTIC AGENT; NEUROPEPTIDE; NORADRENALIN; PERGOLIDE; PRECLAMOL; PROPYLNORAPOMORPHINE; PSYCHOTROPIC AGENT; QUINPIROLE; TALIPEXOLE; TERGURIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; HISTOLOGY; INTRACELLULAR RECORDING; IONTOPHORESIS; MAMMAL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMAL; CENTRAL NERVOUS SYSTEM; DOPAMINE; ELECTROPHYSIOLOGY; HUMAN; NEURONS; RECEPTORS, DOPAMINE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024161730     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(88)80073-3     Document Type: Review

References (437)

1. The activity of pars compacta neurons of the monkey substantia nigra is depressed by apomorphine
2. Lysergic acid diethylamide: Sensitive neuronal units in the midbrain raphe
3. Central dopaminergic neurons: Neurophysiological identification and response to drugs
4. Pre- and postsynaptic feedback mechanisms in central dopaminergic neurons
5. Dopamine “autoreceptors.” Pharmacological characterization by microiontophoretic single cell recording studies
6. Intracellular identification of central noradrenergic and serotoninergic neurons by a new double labelling procedure
7. Endogenous opioids: Biology and function
8. Apomorphine-induced inhibition of neostriatal activity is enhanced by lesions induced by 6-hydroxydopamine but not by long-term administration of amphetamine
9. Effects of clozapine on the turnover of dopamine in corpus striatum and in the limbic system
10. The phenomenology of experimentally induced psychosis—preliminary observations
11. Amphetamine psychosis Behavioral and biochemical aspects
12. Psychoses induced by central neurons system stimulants and related drugs
13. Dopamine autoreceptor subsensitivity: A mechanism common to the treatment of depression and the induction of amphetamine psychosis?
14. n-n-Propylnorapomorphine: An extremely potent stimulant of dopamine autoreceptors
15. RDS-127 (z-di-n-propylamino-4,7-dimethoxyindane); central effects of new dopamine receptor agonists
16. Brain aminergic axons exhibit marked variability in conduction velocity
17. A pharmacological study of changes in CNS receptors responsiveness after long-term dextroamphetamine and apomorphine administration
18. Mechanisms underlying tardive dyskinesia
19. Presynaptic dopamine receptors: Insensitivity to kainic acid and the development of supersensitivity following chronic haloperidol
20. Evidence for an irreversible interaction of bromocriptine with central dopamine receptors
21. Mesocortical dopamine neurons: Lack of autoreceptors modulating dopamine synthesis
22. Mesocortical dopamine neurons: Rapid transmitter turnover compared to other brain catecholamine systems
23. Unique response to antipsychotic drugs is due to the absence of terminal autoreceptors in mesocortical dopamine neurons
24. Pharmacology of dopamine neurons innervating the prefrontal cingulate and piriform cortices
25. Pharmacology of mesocortical dopamine neurons
26. In vivo biochemical and electrophysiological studies on the distribution and pharmacology of dopamine autoreceptors
27. The electrophysiological and biochemical pharmacology of the mesolimbic and mesocortical dopamine neurons
28. Preliminary observation on abnormal catecholamine metabolism in basal ganglia disease
29. The clinical physiology of side effects in long-term L-DOPA therapy
30. Action of systemic apomorphine on dopamine cell firing after neostriatal kainic acid lesion
31. Effects of clozapine on central catecholaminergic neurone systems
32. Treatment of schizophrenia
33. Efferent connections of the substantia nigra and ventral tegmental area in the rat
34. Effect of estrogens on apomorphine-induced circling behavior in the rat
35. Estrogens, progesterone, and the extrapyramidal system
36. A comparison of amphetamine psychosis and schizophrenia
37. Tardive dyskinesia: Clinical, biological, and pharmacological perspectives
38. Evidence for two functionally distinct subpopulations of neurons within the striatum and their differential sensitivity to dopamine
39. Differential electrophysiological effects of 3-PPP and its enantiomers on dopamine autoreceptors
40. Occurrence and distribution of dopamine in brain and other tissues
41. Occurrence and distribution of catecholamines in brain
42. Effects of amphetamine and desmethylimipramine on amine synthesis and release in central catecholamine-containing neurons
43. Der L-dioxyphenylalanin (L-DOPA)—Effect bein der Parkinsonakinese
44. Dopamine in dendrites of substantia nigra neurons Suggestions for a role in dendritic terminals
45. Dopamine containing systems in the CNS
46. Catecholaminergic brain stem regulatory systems
47. To spritz or not to spritz: The doubtful value of aimless iontophoresis
48. Central dopamine turnover in schizophrenic syndromes
49. Biochemical processes in schizophrenia An update
50. The measurement of dose in microelectrophoresis experiments
51. Intrastriatal kainic acid Acute effects on electrophysiological and biochemical measures of nigrostriatal dopaminergic activity
52. The role of tetrahydropteridines in the enzymatic conversion of tyrosine to 3,4-dihydroxyphenylalanine
53. Olfactory relationships of the telencephala and diencephala in the rabbit: ii. An autoradiographic and horseradish peroxidase study of the efferent connection of the anterior olfactory nucleus
54. Midbrain dopamine neurons: Differential responses to amphetamine isomers
55. On the origin of substance P and glutamic acid decarboxylase in the substantia nigra
56. Electrophysiological effects of amphetamine on dopaminergic neurons
57. Comparison of effects of L-DOPA amphetamine and apomorphine on the firing rate of rat dopaminergic neurons
58. Dopaminergic neurons: Effect of antipsychotic drugs and amphetamine on single cell activity
59. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons
60. Antipsychotic drugs and central dopaminergic neurons: A model for predicting therapeutic efficacy and evidence of extrapyramidal side effects
61. The effects of antipsychotic drugs on the firing rate of dopaminergic neurons
62. Evidence for drug action on both pre- and postsynaptic receptors in the CNS
63. Effects of molindone on central dopaminergic neuronal activity and metabolism: Similarity to other neuroleptics
64. d-Amphetamine-induced inhibition of central dopaminergic neurons: Mediation by a striatonigral feedback pathway
65. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique
66. Dopaminergic influence in the basal ganglia: Evidence for striatonigral feedback regulation
67. Central dopaminergic systems: Two in vivo electrophysiological models for predicting therapeutic efficacy and neurological side effects of putative antipsychotic drugs
68. Acute and chronic haloperidol treatment: Comparison of effects of nigral dopaminergic cell activity
69. d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striatonigral feedback pathway
70. The electrophysiological pharmacology of midbrain dopaminergic systems
71. Effect of clonidine on dopaminergic neuron activity in the substantia nigra: Possible indirect mediation by noradrenergic regulation of the serotoninergic raphe system
72. +-3-PPP: A selective dopamine autoreceptor agonist? Electrophysiological studies in the basal ganglia
73. Electrophysiological identification of midbrain dopaminergic neurons
74. In vivo effects of acute and chronic antipsychotic drug administration on midbrain dopaminergic neuron activity
75. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system
76. Effect of single and repeated administration of clozapine on the metabolism of dopamine and noradrenaline in the brain of the rat
77. History of psychopharmacology
78. Parkinsonism
79. Effect of dopamine denervation of the basal ganglia on an animal's response to reward and aversive stimulation
80. On the presence of 3-hydroxytyramine in brain
81. The occurrence, distribution and physiological role of catecholamines in the nervous system
82. Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain
83. Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons
84. Dopaminergic autoreceptors
85. Does dopamine play a role in schizophrenia?
86. Perspectives on the discovery of central monoaminergic neurotransmission
87. Effect of immunoneutralization of substance P in the cat substantia nigra on the release of dopamine from dendrites and terminals of dopaminergic neurons
88. Dendritic release of dopamine in the substantia nigra
89. Reciprocal influences of activating and immobilizing stimuli on the activity of nigro-striatal dopamine neurons
90. 3H-spiperone in the rat
91. Sensory stimuli alter the discharge rate of dopamine neurons: Evidence for two types of DA cells in the substantia nigra
92. Estrogen potentiates the stereotypy induced by dopamine agonists in the rat
93. Alterations in basal firing rate and autoreceptor sensitivity of dopamine neurons in the substantia nigra following acute and extended exposure to estrogen
94. Typical and atypical neuroleptics: Differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
95. Electrophysiological studies on EMD 23 448, an indolyl-3-butylamine, in the rat: A putative selective dopamine autoreceptor agonist
96. Proglumide selective antagonism of excitatory effects of cholecystokinin in the central nervous system
97. Substantia nigra dopamine neurons: Alterations in basal discharge rates and autoreceptor sensitivity induced by estrogen
98. Effects of dopamine antagonists on midbrain dopamine cell activity
99. Mesocortical DA systems Electrophysiological characterization of pre- and postsynaptic neurons
100. Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of midbrain dopamine neurons
101. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
102. Interactions between dopamine and amino acid excitation and inhibition in the striatum: Microiontophoretic studies
103. Midbrain dopamine neurons: Electrophysiological studies on the acute effects of estrogen
104. Pharmacological alterations of chronic neuroleptic-induced depolarization inactivation on midbrain dopamine-containing neurons
105. Population response of midbrain dopaminergic neurons to neuroleptics: Further studies on time course and nondopaminergic neuronal influences
106. Electrophysiological studies on the specificity of the cholecystokinin receptor agonist proglumide
107. Mesencephalic dopamine-containing neurons in culture: Morphological and electrophysiological characterization
108. Dopamine agonist pretreatment alters LSD's electrophysiological action from dopamine agonist to antagonist
109. (+)- and (-)-3-PPP exhibit different intrinsic activity at striatal dopamine autoreceptors controlling dopamine synthesis
110. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system
111. The D1 dopamine receptors: The search for a function. A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications
112. An electrophysiological and pharmacological characterization of identified nigrostriatal and mesoaccumbens dopamine neurons in the rat
113. The influence of striatal stimulation and putative neurotransmitters on identified neurons in the rat substantia nigra
114. Actions of substance P and opiates in the rat substantia nigra
115. Inward and delayed outward membrane currents in isolated neural somata under voltage change
116. Voltage clamp studies of a transient outward current in gastropod neural somata
117. Predication of repetitive firing behavior from voltage clamp data on a isolated neurone soma
118. The effect of some psychoactive drugs on central monoamine neurons
119. Persistent dyskinesia
120. Microelectrophoresis
121. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the central nervous system
122. Making visable the invisable (recollections of the first experiments with the histochemical fluorescence method for visualization of tissue monoamines)
123. Substance P in the substantia nigra
124. Relations between movement and single cell discharge in the substantia nigra of the behaving monkey
125. Electrophysiological properties of identified output neurons of the rat substantia nigra (pars compacta and pars reticulata): Evidence for the existance of branched neurons
126. Electrophysiological identification of mesencephalic ventromedial tegmental (VTA) neurons projecting to the frontal cortex, septum, and nucleus accumbens
127. Preferential stimulation of dopamine release in the mesolimbic system: A common feature of drugs of abuse
128. The anatomical basis for feedback and feedforward in the striatonigral system
129. A metachromatic stain for neural tissue
130. Evidence for the existence of a raphe projection to the substantia nigra in the rat
131. Synaptic mechanisms in the substantia nigra
132. Vertrilung non noradrenalin und dopamine (3-hydroxytryramin) in gehirn des mensuchten und ihr verhalton bei erkrankungen des extrapyramidalen systems
133. Effect of continuous systemic infusion of d-amphetamine on the sensitivity of nigral dopamine cells to apomorphine inhibition of firing rates
134. The putative dopamine autoreceptor agonist B-HT 920 decreases dopamine cell firing and prolactin release in rat
135. The tachykinin peptide family
136. β-(3,4,-Di-hydroxyphenyl)ethylamine (hydroxytyramine) in normal human urine
137. Activity of neurons in the ventral tegmental region of the behaving monkey
138. Evidence for dopamine autoreceptors in mesocortical dopamine neurons
139. Amantadine versus trihexylphenidyl in the treatment of neuroleptic-induced parkinsonism
140. γ-Aminobutyric acid and caudato-nigral inhibition
141. Efferent projections of the anterior olfactory nucleus
142. An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat
143. Reward, motivation, cognition: Psychobiology of mesotelencephalic dopamine systems
144. Demonstration of the existence of small local circuit neurons in the Golgi-stained primate substantia nigra
145. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
146. Firing properties of substantia nigra dopaminergic neurons in freely moving rats
147. Chronic neuroleptic effects on dopamine neuron activity: A model for predicting therapeutic efficacy and side effects?
148. Activity of A9 and A10 dopaminergic neurons in unrestrained rats: Further characterization and effects of apomorphine and cholecystokinin
149. Dopamine-cholecystokinin interactions in the central nervous system
150. Multiple effects of cholecystokinin octapeptide on identified nigrostriatal dopaminergic neurons
151. Interactions of CCK and CCK antagonists with midbrain dopaminergic neurons: Electrophysiological aspects
152. Effects of phencyclidine on ventral tegmental A10 dopamine neurons in the rat
153. Determination of antidromic excitation by the collision test: Problems of interpretation
154. Haloperidol-induced presynaptic dopamine supersensitivity is blocked by chronic lithium
155. Regulation of dopamine synthesis in the medial prefrontal cortex is mediated by release modulating autoreceptors: Studies in vivo
156. Feedback loop or output pathway in striatonigral fibers?
157. Dopamine release in substantia nigra?
158. Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area
159. Crossed connections of the substantia nigra in the rat
160. Dopaminergic neuronal responses to a nonamphetamine CNS stimulant
161. Electrophysiological examination of the ventral tegmental A10 areas in the rat
162. Effects of severe dopamine depletion on dopamine neuronal impulse flow and on tyrosine hydroxylase regulation
163. The relationship of circulating estradiol to tardive dyskinesia in men and postmenopausal women
164. Modulation of dopamine receptor sensitivity by estrogen
165. GABA agonist excitation of nigral dopamine cells mediation through reticulata inhibitory neurons
166. Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons
167. Nigral dopamine neurons: Intracellular recording and identification with L-DOPA injection and histofluorescence
168. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
169. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates
170. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—3. Evidence of electrotonic coupling
171. Nigral dopaminergic neurons: Extracellular and intracellular electrophysiological studies
172. The control of firing pattern in nigral dopamine neurons: Single spike firing
173. The control of firing pattern in nigral dopamine neurons: Burst firing
174. Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity
175. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology
176. Dopamine
177. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: Analysis using in vivo intracellular recording
178. The regulation of dopamine neurone activity as determined by in vivo and in vitro intracellular recordings
179. Distinguishing the rate-increasing and GABA-attenuating actions of dopamine on substantia nigra pars reticulata neurons: Differential effects of D-1 and D-1 agonists
180. Effects of amphetamine on single cell activity in a catecholamine nucleus, the locus coeruleus
181. Compartmental organization of the mammalian striatum
182. Biochemical anatomy of the striatum
183. Paranoid episodes induced by drugs
184. Self-inhibition by dopaminergic neurons
185. Self-inhibition of dopaminergic neurons: Distribution by (+)-alpha-methyl-paratyrosine pretreatment on anterior diencephalic lesions
186. Neuronal interactions in the substantia nigra revealed by statistical analysis of neuronal spike trains
187. Changes in dopaminergic terminal excitability by amphetamine and haloperidol
188. Neuronal mechanisms of action of amphetamine
189. Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra
190. Delayed iontophoretic ejection of substance P from glass micropipettes: Correlation with time course of neuronal excitation in vivo
191. Morphine-induced activation of A10 dopamine neurons in the rat
192. Membrane changes of Onchidium nerve cell in potassium-rich media
193. Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat
194. Differential effects of typical and atypical antipsychotic drugs on the activity of dopamine neurons and their postsynaptic target cells
195. The dopamine hypothesis: An overview of studies with schizophrenic patients
196. Zetidoline blocks dopamine autoreceptors in the rat substantia nigra
197. On the source of GABA-containing terminals in the rat substantia nigra. Electron microscopic, autoradiographic and biochemical studies
198. 3H-estradiol in catecholamine neurons of rat brainstem: Combined localization by autoradiography and formaldehyde-induced fluorescence
199. The history and development of microiontophoresis in experimental neurobiology
200. The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion
201. A subpopulation of mesencephalic dopamine neurons projecting to limbic area contains a cholecystokinin-like peptide, evidence from immunohistochemistry combined with retrograde tracing
202. Antispychotic medications and the treatment of schizophrenia
203. Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways
204. Cholecystokinin-like peptides potentiate apomorphine-induced inhibition of dopamine neurons
205. Projections of substance P containing neurons from neostriatum to substantia nigra
206. Dopamine (3-hydroxytyramine) and brain function
207. Psychopharmacological implications of dopamine and dopamine antagonists: A critical evaluation of current evidence
208. Dopamine in Parkinson's disease and other neurological disorders
209. A quarter century of brain dopamine research
210. Increased sensitivity after estrogen treatment using the rat rotational model
211. Elevation of striatal dopamine receptors by estrogen: Dose and time studies
212. Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra
213. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra
214. Behavioral effects of substance P through dopaminergic pathways in the brain
215. Behavioral effects of manipulation of basal ganglia transmitters
216. Stimulation of retinal dopamine biosynthesis in vivo by exogenous tetrahydrobiopterin relationship to tyrosine hydroxylase activation
217. Effects of morphine and haloperidol on the electrical activity or rat nigrostriatal neurons
218. Basal ganglia and other afferent projections to the peribrachial region in the rat: A study using retrograde and anterograde transport of horseradish peroxidase
219. Nucleus tegmenti pedunculopontinus: Efferent connections with reference to the basal ganglia, studied in the rat by anterograde and retrograde transport of horseradish peroxidase
220. Chronic L-DOPA pretreatment of rats An electrophysiological and biochemical study in the basal ganglia
221. Electrophysiological properties of guinea-pig thalamic neurones: An in vitro study
222. Ionic basis for the electroresponsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro
223. Substance P in the nervous system
224. The substantia nigra of the rat: A Golgi study
225. Dopaminergic and neostriatal neurons: Dose-dependent changes in sensitivity to amphetamine following long-term treatment
226. Long-term amphetamine treatment attenuates or reverses the depression of neuronal activity produced by dopamine agonists in the ventral tegmental area
227. Iontophoretic evidence for subsensitivity of postsynaptic dopamine receptors following long-term amphetamine administration
228. Evidence for the existence of substance P containing fibers in striatonigral and pallidonigral pathways in rat brain
229. Dopamine neurons in culture: A model system for examination of neuronal biopterin metabolism
230. Multiple receptors for dopamine
231. Dynorphin immunohistochemistry in the rat central nervous system
232. Role of gamma-amino-butyric acid (GABA) in the extrapyramidal motor system—2. Some evidence for the existance of a type of GABA-rich striato-nigral neurons
233. Novel neuropeptides neurokinin α and β isolated from porcine spinal cord
234. Electrical membrane properties of rat substantia nigra compacta neurons in an in vitro slice preparation
235. A pharmacological analysis of Huntington's chorea
236. The pharmacology of tardive dyskinesias
237. The effect of d-amphetamine on choreiform movement disorders
238. Therapeutic approaches to neuroleptic-induced tardive dyskinesia
239. Do antidromic latency jumps indicate axonal branching in nigrostriatal and hypothalamo-neurohypophyseal neurons?
240. Diminished responses of nigral dopaminergic neurons to haloperidol and morphine following lesions in the striatum
241. Dopamine release in substantia nigra?
242. Dopamine acts on D2 receptors to increase potassium conductance in neurons of the rat substantia nigra zona compacta
243. The effects of iontophoretically applied substance K (SK) on single unit activity in the rat substantia nigra (SN)
244. Dopamine decreases conductance of the electrical junctions between cultured retinal horizontal cells
245. Electrophysiological changes in substantia nigra after dynorphin administration
246. Treatment of advanced Parkinson's disease with pergolide
247. Antidromic activation of neurons as an analytical tool in the study of the central nervous system
248. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices
249. Electrophysiological properties of in vitro cell dendrites in mammalian cerebellar slices
250. Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances
251. Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro
252. Electrophysiology of pars compacta cells in the in vitro substantia nigra-A possible mechanism for dendritic release
253. Acute psychosis and ritalin abuse
254. Steroid receptor levels in intact and ovariectomized estrogen-treated rats: An examination of quantitative, temporal, and endocrine factors influencing the efficacy of an estradiol stimulus
255. Comparative effect of clozapine and alpha-adrenoceptor blocking drugs on regional noradrenalin metabolism in rat brain
256. Dopamine receptor antagonism by the novel antianxiety drug, buspirone
257. Catechol estrogens and estrogen receptors
258. Response of dopamine neurons in substantia nigra to muscimol
259. Effect of peripheral stimulation on the activity of neurons in the ventral tegmental area, substantia nigra, and midbrain reticular formation of rats
260. Substance K: A novel tachykinin in mammalian spinal cord
261. The need for continuous use of antiparkinsonism medication with chronic schizophrenic patients receiving long-term neuroleptic therapy
262. The autoradiographic distribution of kassinin and substance K binding sites is different from the distribution of substance P binding site in rat brain
263. 3H]guinuclidinyl benzilate binding in rats
264. Pharmacological profile of a novel potent direct-acting dopamine agonist (+)-4-propyl-9-hydroxynaphthoxane [(+)-PHNO]
265. Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine
266. Effects of zoxazolamine and related centrally acting muscle relaxants on nigrostriatal dopaminergic neurons
267. Evidence for a functional role of dopamine type-1 (D-1) receptor in the substantia nigra of rats
268. Antipsychotic drug actions: A clue to the neuropathology of schizophrenia?
269. Evidence that nigral substance P controls the activity of nigrotectal GABAergic pathway
270. The dopamine hypothesis of schizophrenia: A review
271. Relevance of dopamine autoreceptors for psychiatry: Preclinical and clinical studies
272. (−)-Sulpiride activates the firing rate and tyrosine hydroxylase activity of dopaminergic neurons in unanesthetized rats
273. Effect of (−)-cathinone, a khat leaf constituent, on dopaminergic firing and dopamine metabolism in the rat brain
274. Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats
275. Zetidoline, a novel neuroleptic, activates nigral dopaminergic neurons in rats
276. Effects of unilateral nigral modulation of substance P transmission on the activity of the two nigrostriatal dopaminergic pathways
277. Anti-muscarinic properties of neuroleptics and drug-induced parkinsonism
278. Mesencephalic dopaminergic unit activity in the behaviorally conditioned rat
279. Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat
280. Catechol compounds in rat tissues and in brains of different animals
281. The afferent and efferent connections of the feline nucleus tegmenti pedunculopontinus pars compactor
282. Tyrosine hydroxylase: The initial step in norepinephrine biosynthesis
283. Neuronal activity of the substantia nigra (pars compacta) after injection of kainic acid into the caudate nucleus
284. Antagonizing effects of haloperidol and bicuculline on inhibition of neurons of the substantia nigra, pars compacta
285. Two fast transient current components during voltage clamp on snail neurons
286. Interactions of neurotensin with brain dopamine systems
287. Interactions of neurotensin and dopamine in limbic structures
288. Release of dopamine in vivo from cat substantia nigra
289. Release of dopamine from terminals and dendrites of the two nigrostriatal dopaminergic pathways in response to unilateral secretory stimuli in the cat
290. Combined treatment of tardive dyskinesia with clonidine and neuroleptics: A follow-up study of three cases for three years
291. Presynaptic dopamine receptors. Development of supersensitivity following treatment with fluphenazine deconate
292. Dopaminergic neurons: Effect of acute and chronic morphine administration on single cell activity and transmitter metabolism
293. SCH 23390, a selective D1 dopamine receptor blocker, enhances the firing rate of nigral dopaminergic neurons but fails to activate striatal tyrosine hydroxylase
294. Short-term effects of dopamine-depleting brain lesions on sponataneous activity of type II striatal neurons Relation to local striatal dopamine levels and behavior
295. Two-color immunohistochemistry from dopamine and GABA neurons in rat substantia nigra and zona incerta
296. On the origin of dynorphin A and alpha-neo-endorphin in the substantia nigra
297. Catecholamine modulation of enkephalin-induced electrophysiological responses in cerebral cortex
298. 3H]quinuclidinyl benzilate binding in rats
299. Relationship of neuroleptic drug effects at brain dopamine, serotonin, α-adrenergic, and histamine receptors to clinical potency
300. Interactions of neuroleptic compounds at α2-adrenergic receptor affinity states in bovine caudate nucleus
301. Effect of estrogens on dopamine autoreceptors in male rats
302. α2-adrenergic receptor affinity states in bovine caudate nucleus
303. Electrophysiological evaluation of a partial agonist of dopamine receptors
304. Differential sensitivity of presumed dopaminergic and non-dopaminergic neurons in rat substantia nigra to electrophysiologically applied substance P
305. Inhibition of pars compacta neurons by dopamine in slices of rat substantia nigra maintained in vitro
306. Actions of substance P, MIF, TRH, and related peptides in the substantia nigra, caudate nucleus, and nucleus accumbens
307. Sensitivity of compacta neurones in the rat substantia nigra slice to dopamine agonists
308. Hyperpolarizing action of baclofen on neurons in the rat substantia nigra slice
309. Action of putative dopamine receptor agonists, TL-99, 3-PPP and RDS-127 on substantia nigra neurons
310. Neurotensin depolarizes substantia nigra dopamine neurons
311. SCH 23390 blocks D-1 and D-2 dopamine receptors in rat neostriatum in vitro
312. The effects of SCH 23390, (+)- and (-)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro
313. The central olfactory connexions
314. Anatomy and physiology of substantia nigra and retrorubral neurons studied by extra- and intracellular recording and by horseradish peroxidase labeling
315. Autoradiographic distribution of substance P receptors in rat central nervous system
316. Multiple tachykinin receptors
317. Behavioral and biochemical correlates after haloperidol and clozapine long-term treatment
318. Effects of phencyclidine on the spontaneous activity of monoaminergic neurons
319. Single unit response of noradrenergic serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuli
320. Ultrastructural observations on intercellular contacts of nigral dendrites
321. GABAergic nerve terminals decrease in the substantia nigra following hemitransections of the striatonigral and pallidonigral pathways
322. Observations on the fine structure of the substantia nigra in the cat
323. In vivo presynaptic control of dopamine release in the cat caudate nucleus—I. Opposite changes in neuronal activity and release evoked from thalamic motor nuclei
324. Dopamine autoreceptors: Pharmacology, function and comparison with postsynaptic dopamine receptors
325. CNS dopamine autoreceptors: Distribution, pharmacology, and function
326. Dopamine autoreceptors: Studies of their distribution and mode of action
327. Micromethods in neuropharmacology: An approach to the study of anesthetics
328. Electrophysiological properties of mouse dopamine neurons: In vivo and in vitro studies
329. Responsiveness of nigral neurons to the stimulation of striatal dopaminergic receptors in the rat
330. Pedunculopontineevoked excitation of substantia nigra neurons in the rat
331. A microiontophoretic study on the nature of the putative synaptic neurotransmitter involved in the pedunculopontine-substantia nigra pars compacta excitatory pathway of the rat
332. Electrophysiological mapping techniques
333. The activity of pars compacta neurons of the substantia nigra in relation to motor activation
334. Response of midbrain dopamine neurons to behavioral trigger stimuli in the monkey
335. Probable calcium spikes in hippocampal neurons
336. Mental disturbance during bromocriptine and lergotrile treatment of Parkinson's disease
337. Psychiatric effects of bromocriptine and lergotrile in parkinsonian patients
338. The central effects of a novel dopamine agonist
339. A subpopulation of mesocortical dopamine neurons possess autoreceptors
340. Tardive dyskinesia and psychotropic drug history
341. The effects of acute and chronic haloperidol treatment on spontaneous firing neurons in the caudate nucleus of the rat
342. Dopamine auto- and postsynaptic receptors: Electrophysiological evidence for differential sensitivity to dopamine agonists
343. Peptide-monoamine coexistence: Studies of the actions of cholecystokinin like peptide on the electrical activity of midbrain dopamine neurons
344. Catecholamines in the brain are mediators of amphetamine psychosis
345. Drugs, neurotransmitters and schizophrenia
346. Psychosis during methylphenidate abuse
347. The effects of long-term amphetamine administration on the activity of dopaminergic neurons of the substantia nigra
348. Single unit activity of dopaminergic neurons in freely moving rats
349. Behavioral correlates of dopaminergic unit activity in freely moving cats
350. The basal ganglia and intellectual function
351. An anatomy of schizophrenia?
352. Schizophrenia and dopamine regulation in the mesolimbic system
353. Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum
354. Independent in vitro regulation by the D-2 dopamine receptor of dopamine-stimulated efflux of cyclic AMP and K+-stimulated release of acetylcholine from rat neostriatum
355. Substantia nigra dopaminergic unit activity in behaving cats: Effect of arousal on spontaneous discharge and sensory evoked activity
356. Dopaminergic unit activity during behavior
357. Brain monoamines, homeostasis, and behavior
358. Reinnervation of dopamine-denervated striatum by substantia nigra transplants Immunohistochemical and electrophysiological correlates
359. On the functional role of pre- and postsynaptic catecholamine receptors in brain
360. Catecholamine receptor agonists Effects on motor activity and rate of tyrosine hydroxylation in mouse brain
361. Sensitivity of neuronal dopamine response in the substantia nigra and ventral tegmentum to clozapine, metaclopramide and SCH 23390
362. Gilles de la Tourette syndrome: A 20-month study of the effects of stressful life events and haloperidol on symptom frequency
363. Dopaminergic terminal excitability following arrival of the nerve impulse: The influence of amphetamine and haloperidol
364. Schizophrenic symptoms improve with apomorphine
365. N-propyl-norapomorphine in the treatment of schizophrenia
366. A simple direct and rapid method for filling microelectrodes
367. The neurophysiology of dopamine nerve terminal autoreceptors
368. Electrophysiologically identified nigral dopaminergic neurons intracellularly labelled with HRP: Light-microscopic analysis
369. Dopamine modulates S-potential amplitude and dye-coupling between external horizontal cells in carp retina
370. Electrophysiological evidence for non-dopaminergic mesocortical and mesolimbic neurons in the rat
371. Three pharmacologically distinct potassium channels in molluscan neurones
372. Activity of substantia nigra units across the sleep-walking cycle in freely moving rats
373. Inhibition of neuronal activity of the substantia nigra by noxious stimuli and its modification by the caudate nucleus
374. Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor
375. Electrophysiological evidence for an input from an anterior olfactory nucleus to substantia nigra
376. Gilles de la Tourette's syndrome: Biochemical approaches
377. Estrogens, dopamine and dyskinesia
378. Estrogens in tardive dyskinesia in male psychiatric patients
379. Dynorphin immunoreactive neurons in the central nervous system
380. The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat
381. Dopaminergic neurons: Inhibition of firing by gammahydroxybutyrate
382. Dopaminergic neurons: Drug induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow
383. ET 495 and apomorphine: Pre- and postsynaptic effects of dopamine synthesis and neuronal activity
384. Piribedil and apomorphine: Pre- and postsynaptic effects on dopamine synthesis and neuronal activity
385. Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors
386. Effect of muscimol on single unit activity of substantia nigra dopamine neurons
387. Dopamine neurons: Effects of lergotrile on unit activity and transmitter synthesis
388. Neurophysiological effects of dopamine agonists in the substantia nigra and globus pallidus
389. Modulation of midbrain dopamine cell activity
390. Effects of SCH 23390-induced blockage of D-1 dopamine (DA) receptors on single-unit activity in substantia nigra and globus pallidus
391. Effects of D-1 and D-2 receptor stimulation on single unit activity in the substantia nigra and globus pallidus
392. Stimulation of D-1 and D-2 dopamine receptors: Synergistic effects on single unit activity in the basal ganglia output nuclei
393. Intradendritic recordings from hippocampal neurons
394. Dopaminergic neurons of the rat ventral tegmental area. I. Identification and characterization
395. Dopaminergic neurons of the rat ventral tegmental area. II. Evidence for autoregulation
396. Dopaminergic neurons of the rat ventral tegmental area. III. Effects of d- and l-amphetamine
397. Effects of dopamine agonists on midbrain dopamine cell activity
398. Intravenous GABA agonist administration stimulates firing of A10 dopaminergic neurons
399. Dopamine modulation of the effects of γ-aminobutyric acid on substantia nigra pars reticulata neurons
400. Endogenous dopamine can modulate inhibition of substantia nigra pars reticulata neurons elicited by GABA iontophoresis or striatal stimulation
401. Dynorphin immunocytochemical in brain and peripheral nervous system: Preliminary studies
402. Comparison of the distribution of dynorphin systems and enkephalin systems in brain
403. Intracellular distribution of catecholamines in the brain
404. Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat
405. Comparison of the effects of LSD and lisuride on A10 dopamine neurons in the rat
406. Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons
407. A10 dopamine neurons: Role of autoreceptors in determining firing rate and sensitivity to dopamine agonists
408. Pharmacological characterization of dopamine autoreceptors in the rat ventral tegmental area: Microiontophoretic studies
409. Electrophysiological evidence for A10 dopamine autoreceptor subsensitivity following chronic d-amphetamine treatment
410. Interactions of cholecystokinin octapeptide and dopamine on nucleus accumbens neurons
411. Electrophysiological studies of the rat mesoaccumbens dopamine systems: Focus on dopamine receptor subtypes, interactions, and the effects of cocaine
412. Monoaminergic synapses, including dendro-dendritic synapses, in the rat substantia nigra
413. Statistical properties of neuronal spike trains in the substantia nigra: Cell types and their interactions
414. Haloperidol-induced alterations of post-firing inhibition in dopaminergic neurons of the rat striatum
415. Dopamine autoreceptors
416. Effect of dopamine agonists and antagonists on the electrical activity of substantia nigra neurons transplanted into the lateral ventricles of the rat
417. Electrophysiology of substantia nigra transplants
418. Electrophysiological, biochemical, and behavioral assessment of dopamine autoreceptor activation by a series of dopamine agonists
419. Effect of picrotoxin and ninpecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens
420. Electrophysiological studies of neurons in the ventral tegmental area of Tsai
421. Paranoid psychosis in narcolepsy and the possible dangers of benzedrine treatment
422. Nicotinic effects on the firing patter of midbrain dopamine neurons
423. The localization and characterization of substance P and substance K in striatonigral neurons