Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats

Peptides

Volumn 9, Issue 5, 1988, Pages 1177-1181

  Tortella, Frank C ^a   Echevarria, Eddie ^a   Robles, Lydia ^a   Mosberg, Henry I ^b   Holaday, John W ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Anticonvulsant effects; DAGO; DPDPE

Indexed keywords

BETA FUNALTREXAMINE; DELTA OPIATE RECEPTOR; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FLUROTHYL; MU OPIATE RECEPTOR; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; N,N DIALLYLTYROSYLGLYCYL ALPHA (2 AMINOETHYLTHIO)HYDROCINNAMOYLLEUCINE; NALOXONE;

ANIMAL CELL; ANIMAL EXPERIMENT; CONTROLLED STUDY; CONVULSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANTICONVULSANTS; CEREBRAL VENTRICLES; CONVULSIONS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; FLUROTHYL; INJECTIONS, INTRAVENTRICULAR; MALE; RATS; RATS, INBRED STRAINS; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 0024150772     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0196-9781(88)90104-0     Document Type: Article

References (46)

1. Dissimilar EEG and behavioral effects of β-endorphin and dynorphin 1–13 in rats
2. Effects of selective mu- and delta-opioid peptides on kindled amygdaloid seizures in rats
3. Intranigral dynorphin 1–13 suppresses kindled seizures by a naloxone-insensitive mechanism
4. Mu opioid receptors participate in the excitatory effect of opiates in the hippocampal slice
5. Limbic postictal events: Anatomical substrates and opioid receptor involvement
6. ICI174,864: A highly selective antagonist for the opioid delta receptor
7. Evidence that endogenous enkephalins produce delta-opiate receptor mediated neuronal inhibitions in rat dorsal horn
8. Electrophysiology of opioids
9. Pro- and anticonvulsant actions of morphine and the endogenous opioids: Involvement and interactions of multiple opiate and non-opiate systems
10. Involvement of mu receptors in the opioid generation of bursting discharges in hippocampal pyramidal cells
11. Infusion of opiate into the substantia nigra protects against maximal electroshock seizures in rats
12. Analogs of beta-LPH-61–64 possessing selective agonists at mu-opiate receptors
13. Beta-endorphin induces non-conclusive limbic seizures
14. Endogenous opioids and their receptors Evidence for involvement in the postictal effects of electroconvulsive shock
15. Electroconvulsive shock activates endogenous opioid systems Behavioral and biochemical correlates
16. The distribution of enkephalin-immunoreactive cell bodies in rat central nervous system
17. Site-directed alkylation of multiple opioid receptors. I. Binding selectivity
18. TYR-D-ALA2-GLY-MePHE-NH(CH2)2-OH is a selective ligand for the mu opiate binding site
19. Intrahippocampal injections of a specific mu receptor ligand PL017 produce generalized convulsions in rats
20. Endogenous opioid peptide: Multiple agonists and receptors
21. Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin-A-like immunoreactivity in rat hippocampus
22. Bis-penicillamine enkephalins show pronounced delta opioid receptor selectivity
23. Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit and hot-plate analgesia in the mouse
24. Cuatracasas, P. Immunohistochemical localization of enkephalin in the rat brain and spinal cord
25. Selective antagonists at the opiate delta receptor
26. Opioid peptides and epileptogenesis in the limbic system: Cellular mechanisms
27. The irreversible narcotic anatagonist and reversible agonist properties of the fumaramate ester methyl derivative of naltrexone
28. Opioid peptides: possible physiological role as endogenous anticonvulsants
29. Dynorphin (1–13): In vivo antagonist actions and non-opioid anticonvulsant effects in the rat flurothyl test
30. Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure
31. An endogenous opioid-like substance regulates neuronal excitability: Characterization of its anticonvulsant properties
32. Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats
33. Endogenous opioid systems: Physiological role in the self-limitation of seizures
34. U50,488, a highly selective kappa opioid: Anticonvulsant profile in rats
35. Electroencephalographic and behavioral effects of D-ALA2-methionine-enkephalinamide and morphine in the rat
36. The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: Interactions between delta and mu receptor antagonists
37. A selective role for delta receptors in the regulation of opioid-induced changes in seizure threshold
38. Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures
39. ICI154,129, a delta opioid receptor antagonist raises seizure threshold in rats
40. Morphine and enkephalin: Analgesic and epileptogenic properties
41. U-54494A: A unique anticonvulsant related to kappa opioid agonists
42. Nonopiate effects of dynorphin and Des-Tyr-dynorphin
43. Immunohistochemical localization of enkephalin in rat forebrain
44. Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration
45. Opiate receptor interactions on single locus coerleus neurones
46. Multiple opiate receptors in peripheral tissue preparations