Hoe 288: Indications on the memory‐enhancing effects of a peptidase inhibitor

Drug Development Research

Volumn 14, Issue 3-4, 1988, Pages 315-324

  Usinger, Patricia ^a   Hock, Franz J ^a   Wiemer, Gabriele ^a   Gerhards, Hermann J ^a   Henning, Rainer ^a   Urbach, Hansjörg ^a  

^a SANOFI   (France)

Author keywords

acetylcholine metabolism; cGMP; choline acetyltransferase; inhibitory avoidance; memory and learning; radial maze

Indexed keywords

1' [N (1 CARBOXY 3 PHENYLPROPYL)ALANYL]SPIRO[BICYCLO[2.2.2]OCTANE 2,3' PYRROLIDINE] 5' CARBOXYLIC ACID] 1 ETHYL ESTER; ACETYLCHOLINE; CHOLINE ACETYLTRANSFERASE; CYCLIC GMP; HEMICHOLINIUM 3;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING; MEMORY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0024146856     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.430140324     Document Type: Article

References (26)

1. Angiotensin converting enzyme in Alzheimers disease: increased activity in caudate nucleus and cortical areas J
2. Memory deficits in aged cebus monkeys and facilitation with central cholinomimetics
3. Cognition activating properties of 3‐(aryloxy)pyridines J
4. Effects of the novel compound aniracetam (Ro 13‐5057) upon impaired learning and memory in rodents
5. On the pathogenesis and therapy of dementia of the Alzheimer type: some neuropathological, biochemical, genetic and pharmacotherapeutic considerations
6. Neuropeptides, mental performance and aging
7. Psychotropic drug influences on brain acetylcholine utilization
8. Radiochemical microassays for the determination of choline acetyltransferase and acetylcholinesterase activities
9. The determination of picomole amounts of acetylcholine in mammalian brain
10. Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells
11. Drug development for senile cognitive decline
12. Enhancing effects of Hoe 175 on memory in mice
13. Neuropeptides and memory
14. Protective effects of ECS on step‐through performance of naive and punished mice
15. Regional sensitivity of cyclic AMP and cyclic GMP in rat brain to central cholinergic stimulation
16. Nerve growth factor promotes cholinergic development in brain striatal cultures
17. Acetylation and phosphorylation of choline in synaptosomes: functional roles for low and high affinity choline uptake
18. Regulation of acetylcholine release in the mouse cerebrum by methionine enkephalin and substance P
19. Leupeptin, a thiol proteinase inhibitor, causes a selective impairment of spatial maze performance in rats Behav
20. Up‐hill avoidance: a new passive avoidance task
21. The storage and release of acetylcholine
22. Conversion of [Met5]‐Enkephalin‐Arg6‐Phe7 to [Met5]‐Enkephalin by dipeptidyl carboxypeptidase
23. Purification and inhibition by neuropeptides of angiotensinconverting‐enzyme from rat brain
24. Cerebrospinal fluid levels of angiotensin‐converting‐enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study