Serum and urinary markers of bone remodeling: Assessment of bone turnover

Endocrine Reviews

Volumn 9, Issue 4, 1988, Pages 437-449

  Epstein, Sol ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CARBOXYGLUTAMIC ACID; 4 CARBOXYGLUTAMIC ACID; ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CALCIUM BINDING PROTEIN; CALCIUM BINDING PROTEINS; CARRIER PROTEIN; HYDROXYPROLINE; MATRIX GLA PROTEIN; MINERAL; OSTEOCALCIN; OSTEONECTIN; PROCOLLAGEN;

ANIMAL; BLOOD; BONE; HUMAN; METABOLIC BONE DISEASE; METABOLISM; REVIEW; URINE;

1-CARBOXYGLUTAMIC ACID; ALKALINE PHOSPHATASE; ANIMAL; BIOLOGICAL MARKERS; BONE AND BONES; BONE DISEASES, METABOLIC; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; HUMAN; HYDROXYPROLINE; MINERALS; OSTEOCALCIN; OSTEONECTIN; PROCOLLAGEN;

EID: 0024120485     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-9-4-437     Document Type: Article

References (177)

1. Jaworski ZFG 1981 Cellular basis of bone structure in health and in osteoporosis. In: Frost HM (ed) Orthopedics Clinics of North America. WB Saunders Co., Philadelphia, vol 12:485
2. Friedenstein AJ 1976 Precursor cells of mechanocytes. Int Rev Cytol 47:327
3. Owen M 1969 The origin of bone cells. Int Rev Cytol 28:213
4. Frost HM 1969 Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res 3:211
5. Fischman DA, Hay ED 1962 Origin of osteoclasts from mononuclear leukocytes in regenerating newt limbs. Anat Rec 143:329
6. Gothln G, Ericsson JLE 1976 The osteoclast. Clin Orthop 120:201
7. Jee WSS, Nolan PD 1963 Origin of osteoclasts from the fusion of phagocytes. Nature 200:225
8. Ash P, Loutit JF, Townsend KMS 1963 Osteoclasts derived from haematopoietic stem cells. Nature 283:669
9. Chambers TJ 1978 Multinucleated giant cells. J Pathol 126:125
10. Burger EH, Van der Meer JWM, Van de Gevel JS, Gribnau JC, Thesingh CW, Van Furth R 1982 In vitro formation of osteoclasts from long term cultures of bone marrow mononuclear phagocytes. J Exp Med 156:1604
11. Robison R 1923 The possible significance of hexosephosphonic esters in ossification. Biochem J 17:286
12. Wright GM, Le Blond CP 1981 Immunohistochemical localisation of procollagens. J Histochem Cytochem 29:791
13. Hauschka PV, Lian JB, Gallop PM 1975 Direct identification of the calcium binding amino-acid carboxyglutamate in mineralised tissue. Proc Natl Acad Sci USA 72:3925
14. Price PA, Otsuka AS, Poser JW, Kristaponis J, Raman N 1976 Characterisation of a carboxyglutamic acid containing protein from bone. Proc Natl Acad Sci USA 73:1447
15. Gallop PM, Lian JB, Hauschka PV 1980 Carboxylated calcium binding proteins, and Vitamin K. N Engl J Med 302:1460
16. Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, Martin GR 1981 Osteonectin. A bone specific protein linking mineral to collagen. Cell 26:99
17. Price PA, Urist MR, Otawara Y 1983 Matrix Gla protein, a new carboxyglutamic acid containing protein which is associated with the organic matrix of bone. Biochem Biophys Res Commun 117:765
18. Hale JE, Fraser JD, Price PA, Matrix Gla protein is a constituent of cartilage as well as bone. Proceedings of the American Society for Bone and Mineral Research, Indianapolis, IN, 1987, vol 1 [Suppl 1]. (Abstract 117)
19. Fisher LW 1985 The nature of the proteoglycans of bone. In: Butler WT (ed) The Chemistry and Biology of Mineralised Tissues. EBSCO Media, Birmingham, AL, p 188
20. Herring GM 1972 The organic matrix of bone. In: Bourne GH (ed) The Biochemistry and Physiology of Bone. Academic Press, New York, vol 1:127
21. Fisher LW, Termine JD, Dejter SW, Whitson SW, Yanagishita M, Kimura JH, Hascall VC, Kleinman H, Hassal JR, Nillson B 1983 Proteoglycans of developing bone. J Biol Chem 258:6588
22. Andrews AT de B, Herring GM 1965 Further studies on bone sialoprotein. Biochim Biophys Acta 101:239
23. Fisher LW, Termine JD 1985 Non-collagenous proteins influencing the local mechanisms of calcification. Clin Orthop 200:362
24. Price P 1983 Non collagenous proteins of hard tissue. In: Peck WA (ed) Bone and Mineral Research, Annual 1. Excerpta Medicine, Amsterdam, p 157
25. Kaye HD 1929 Plasma phosphatase in osteitis deformans and in other diseases of bone. Br J Exp Pathol 10:253
26. Shifrin LZ 1970 Correlation of serum alkaline phosphatase with bone formation rates. Clin Orthop 70:212
27. Round JM 1973 Plasma calcium, magnesium, phosphorus and alkaline phosphatase levels in normal British school children. Br Med J 3:137
28. Singer FR, Schiller AL, Pyle EB, Krane SM 1978 Paget’s disease of bone. In: Avioli LV, Krane SM (eds) Metabolic Bone Disease. Academic Press, New York, p 489
29. Avramides A, Flores A, De Rose J, Wallach S 1976 Paget’s disease of bone. Observations after cessation of long term synthetic salmon calcitonin treatment. J Clin Endocrinol Metab 42:459
30. Doppelt SH 1984 Vitamin D, rickets and osteomalacia. Symposium on metabolic bone disease. Orthop Clin North Am 15:671
31. Borrie MJ, Campbell JA, Caradoc-Davies TH 1985 Osteomalacia in the elderly. Investigation and diagnosis. N Z Med J 98:989
32. Mora Palma FJ, Ellis HA, Cook DB, Dewar JH, Ward MK, Wilkinson R, Kerr DNS 1984 Osteomalacia in patients with chronic renal failure before dialysis or transplantation. Q J Med New Series LII 207:332
33. McComb R, Bowers GN, Posen S (eds) 1979 Alkaline Phosphatase. Plenum Press, New York, chapt 9, p 570
34. Posen S, Cornish C, Kleerekoper M 1977 Alkaline phosphatase and metabolic bone disorders. In: Avioli LV, Krane SM, (eds) Metabolic Bone Disease. Academic Press, New York, vol 1:141
35. Posen S, Grunstein HS 1982 Turnover rate of skeletal alkaline phosphatase in humans. Clin Chem 28:153
36. Slaughter CA, Coseo MC, Harris H 1981 Detection of enzyme polymorphism by using monoclonal antibodies. Proc Natl Acad Sci USA 78:1124
37. Lawson GM, Katzmann JA, Kimlinger TK, O’Brien JF 1985 Isolation and preliminary characterization of a monoclonal antibody that interacts preferentially with the liver isoenzyme of human alkaline phosphatase. J Clin Chem 3:381
38. Duda RJ, O’Brien JF, Katzmann JA, Peterson JM, Mann KG, Rigg BL 1988 Concurrent assays of circulating bone-gla protein and bone alkaline phosphatase: effects of sex, age and metabolic bone disease. J Clin Endocrinol Metab 66:951
39. Kuwana T, Sugita O, Yakata M 1988 Reference limits of bone and liver alkaline phosphatase isoenzymes in the serum of healthy subjects according to age and sex as determined by wheat germ lectin affinity electrophoresis. Clin Chim Acta 173:273
40. Genant HK, Heck LL, Lanzl LH, Rossman K, Van Der Horst J, Paloyan E 1973 Primary hyperparathyroidism. A comprehensive study of clinical, biochemical and radiological manifestations. Radiology 109:513
41. Nagant de Deauxchaisnes C, Krane ST 1967 The treatment of adult phosphate diabetes and Fanconi’s syndrome with neutral phosphate. Am J Med 43:508
42. Malluche HH, Faugere MC, Fanti P, Price P 1984 Plasma levels of bone Gla protein reflect bone formation in patients on chronic maintenance dialysis. Kidney Int 26:869
43. Coburn JW, Slatopolsky E 1981 Vitamin D, parathyroid hormone and renal osteodystrophy. In: Brenner BM, Rector FC (eds) The Kidney. WB Saunders Co, Philadelphia, vol 2:2213
44. Hodsman AB, Sherrard DJ, Wong EGC, Brickman AS, Lee DBN, Alfrey AC, Singer FR, Norman AW, Coburn JW 1981 Vitamin D resistant osteomalacia in hemodialysis patients lacking secondary hyperparathyroidism. Ann Intern Med 96:629
45. Coburn JW, Alfrey AC (eds) 1986 Conference on aluminum related diseases. Kidney Int [Suppl] 18:558
46. Kleerekoper M, Ibels LS, Ingham JP, McCarthy SW, Mahony JF, Stewart JF, Posen S 1975 Hyper-parathyroidism after renal transplantation. Br Med J 3:680
47. Nagant de Deuxchaisnes C, Krane SM 1964 Paget’s disease of bone. Clin Metab Obser Med 43:233
48. Woodard HQ 1958 Long term studies on the blood chemistry in Paget’s disease of bone. Cancer 12:1226
49. Lebbin D, Ryan WG, Schwartz TB 1974 Outpatient treatment of Paget’s disease of bone with mithramycin. Ann Intern Med 81:635
50. Haddad JG, Birge SF, Avioli LV 1970 Effects of prolonged thy-rocalcitonin administration on Paget’s disease of bone. N Engl J Med 283:549
51. Altman RD, Johnston CC, Khairi MRA, Wellman H, Serafini AN, Sankey RR 1973 Influence of sodium etidronate on clinical and laboratory manifestations of Paget’s disease of bone (osteitis deformans). N Engl J Med 289:1379
52. Plehive WE, Hudson J, Clifton Bligh P, Posen S 1977 Porcine calcitonin in the treatment of Paget’s disease of bone. Med J Aust 1:577
53. Galasko CS 1972 Skeletal metastases and mammary cancer. Ann R Coll Surg Engl 50:3
54. Prockop DJ, Underfriend S 1960 A specific method for the analysis of hydroxyproline in tissues and urine. Anal Biochem 1:228
55. Kivirikko KI 1970 Urinary excretion of hydroxyprolines in health and disease. Int Rev Connect Tissue Res 5:93
56. Krane SM, Munoz AJ, Harris Jr ED 1970 Urinary polypeptides related to collagen synthesis. J Clin Invest 49:716
57. Nusgens B, Lapiere CM 1973 The relationship between proline and hydroxyproline excretion in humans as an index of collagen metabolism. Clin Chim Acta 48:203
58. Niell HB, Palmieri GM, Neely CL, McDonald M 1981 Postab-sorptive urinary hydroxyproline test in patients with metastatic bone disease from breast cancer. Arch Intern Med 141:1471
59. Powles TJ, Rosset G, Leese CL, Bondy PK 1976 Early morning hydroxyproline excretion in patients with breast cancer. Cancer 38:2564
60. Christiansen C, Riis BJ, Rodbro P 1987 Prediction of rapid bone loss in post menopausal women. Lancet 1:1105
61. Russell RGG, Preston C, Smith R, Walton RJ, Woods W 1974 Diphosphonates in Paget’s disease of bone. Lancet 1:894
62. Evans IMA, Doyle FH, Banks L, Pennock J, Joplin GF, MacIntyre I 1977 Paget’s disease: results of long term treatment with synthetic human calcitonin. In: MacIntyre J, Szelke M (eds) Molecular Endocrinology. Proceedings of Endocrinology 77, London. Elsevier, North Holland, Amsterdam, p 235
63. Singer FR, Fredericks RS, Minkin C 1980 Salmon calcitonin therapy for Paget’s disease of bone. The problem of acquired clinical resistance. Arthritis Rheum 23:1148
64. Eyre D, Ericsson L, Simon L, Krane S 1988 Identification of urinary peptides derived from cross-linking sites in bone collagen in Paget’s disease. J Bone Mineral Res 3 [Suppl 1]:565
65. Linde A 1984 Non collagenous proteins and proleoglygans in dentinogenesis. In: Linde A (ed) Dentin and Dentogenesis. CRC Press, Boca Raton, FL, vol 2:55
66. Dimuzio MT, Brown M, Butler WT 1983 The biosynthesis of dentine 7 carboxyglutamic acid containing protein by rat incisor odontoblasts in organ culture. Biochem J 216:249
67. Lian JB, Prien Jr EL, Glimcher MJ, Gallop PM 1977 The presence of protein bound 7-carboxyglutamic acid in calcium-containing renal calculi. J Clin Invest 59:1151
68. Levy RJ, Lian JB, Gallop P 1979 Atherocalcin a 7-carboxy-glutamic acid containing protein from atherosclerotic plaque. Biochem Biophys Res Commun 91:41
69. Lian JB, Hauschka PV, Gallop PM 1978 Properties and biosynthesis of vitamin K dependent calcium binding protein in bone. Fed Proc 37:2615
70. Hauschka PV 1985 Osteocalcin and its functional domains. In: Butler WT (ed) The Chemistry and Biology of Mineralised Tissues. EBSCO Media. Birmingham, AL, p 149
71. Price PA, Poser JW, Raman N 1976 Primary structure of the carboxyglutamic acid containing protein from bovine bone. Proc Natl Acad Sci USA 73:3374
72. Poser JW, Esch FS, Ling NC, Price PA 1980 Isolation and sequence of the vitamin K dependent protein from human bone under decarboxylation of the first glutamic acid residue. J Biol Chem 255:8685
73. Carr SA, Hauschka PV, Biemann IC 1981 Gas chromatographic mass spectrometric sequence determination of osteocalcin and carboxyglutamic acid containing protein of chicken bone. J Biol Chem 256:9944
74. Hauschka PV, Gallop PM 1977 Purification and calcium binding properties of osteocalcin, the carboxyglutamic containing protein of bone. In: Wasserman RH (ed) Calcium Binding Proteins and Calcium Function. Elsevier, Amsterdam, p 338
75. 2D:); parathyroid hormone and glucocorticoids. Metab Bone Dis Related Res 5:229
76. Nishimoto SK, Price PA 1979 Proof that the carboxyglutamic acid containing bone protein is synthesised in calf bone. J Biol Chem 254:437
77. Hauschka PV, Reid ML 1978 Vitamin K dependence of a calcium binding protein containing carboxyglutamic acid in chicken bone. J Biol Chem 253:9063
78. Price PA 1985 Vitamin K dependent formation of Bone Gla protein (osteocalcin and its function). Vitam Horm 2:65
79. Hauschka PV, Carr SA 1982 Calcium dependent a-helical structure in osteocalcin. Biochemistry 21:2538
80. Traverso HP, Hauschka PV, Gallop PM 1980 Vitamin K dependent 7-carboxyglutamic acid formation by mouse renal adenocarcinoma cells (RAG). Calcif Tissue Int 30:73
81. Traverso HP, Hauschka PV, Gallop PM 1979 Vitamin Independent carboxylation in microsomal preparations derived from cultured kidney cells, chick embryo fibroblasts and pancreas. In: Suttie JW (ed) Vitamin K Metabolism and Vitamin K Dependent Proteins. University Park Press, Baltimore, p 311
82. Van Buskirk JJ, Kirsch WM 1978 The occurrence of 7-carboxy-glutamic acid in mammalian ribosomes. Biochem Biophys Res Commun 80:1033
83. McIntosh MJ, Olivera BM, Cruz LJ, Gray WR 1984 7-Carboxy-glutamate in a neuroactive toxin. J Biol Chem 23:14343
84. 1 stimulates transcription of bone Gla protein gene. Am Soc Bone Mineral Res 1: [Suppl 1] (Abstract 20)
85. Lian JB, Coutts MC, Canalis E 1985 Studies of hormonal regulation of osteocalcin synthesis in fetal rat calvariae. J Biol Chem 260:8706
86. Haberstroh LM, Price PA 1986 The intron-exon structure of the rat bone gla protein. Am Soc Bone Mineral Research 1: [Suppl 1] (Abstract 134)
87. Kaplan GC, Eilon G, Poser JW, Jacobs JW 1985 Constitutive biosynthesis of bone Gla protein (BGP) in a human osteosarcoma cell line. Am Soc Bone Mineral Res Vol 1: [Suppl 1] (Abstract 261)
88. Celeste AJ, Rosen V, Buecker JL, Kriz R, Wang EA, Wozney JM 1986 Isolation of the human gene for bone Gla protein utilizing mouse and rat cDNA clones. Embo J 5:1885
89. Riggs BL, Tsai KS, Mann KG 1986 Effect of acute increases in bone matrix degradation on circulating levels of bone Gla protein. J Bone Mineral Res 1:539
90. Delmas P 1988 Biochemical markers of bone turnover. In: Riggs BL, Melton J (eds) Osteoporosis. Raven Press, New York, p 303
91. Bronckers ALJJ, Gay S, DiMuzio MT, Butler WT 1985 Immu-nolocalization of 7-carboxyglutamic acid containing protein in developing rat bone. Collagen Related Res 5:7
92. 47Ca-kinetics. J Clin Invest 76:2254
93. a in osteosarcoma cells. J Biol Chem 259:5844
94. t and dexamethasone on rat osteoblast-like primary cell cultures: receptor occupancy and functional expression patterns for three different bioresponses. Endocrinology 118:250
95. Hauschka PV, Reid ML 1978 Timed appearance of a calcium binding protein containing 7-carboxyglutamic acid in developing chick bone. Dev Biol 65:426
96. Price PA, Lothringer JW, Baukol SA, Redde AH 1981 Developmental appearance of the vitamin K dependent protein of bone during calcification. J Biol Chem 256:3781
97. Malone JD, Teitelbaum GL, Griffin GL, Senior RM, Kahn AJ 1982 Recruitment of osteoclast precursors by purified bone matrix constituents. J Cell Biol 92:227
98. Mundy GR, Poser JW 1983 Chemotactic activity of the 7-carboxyglutamic acid containing protein in bone. Calcif Tissue Int 35:164
99. Hauschka PV, Reid ML 1978 Vitamin K dependence of calcium binding protein containing 7-carboxyglutamic acid in developing chick bone. J Biol Chem 253:9063
100. Price PA, Williamson MK 1981 Effects of Warfarin on bone studies on the vitamin K dependent proteins of rat bone. J Biol Chem 256:12754
101. Price PA, Williamson MK, Haba T, Dell RB, Jee WSS 1982 Excessive mineralization with growth plate closure in rats on chronic Warfarin treatment. Proc Natl Acad Sci USA 79:7734
102. Lian JB, Tassinari M, Glowacki J 1984 Resorption of implanted bone prepared from normal and Warfarin treated rats. J Clin Invest 73:1223
103. Lian JB, Dunn K, Key LL 1986 In vitro degradation of bone particles by human monocytes is decreased with depletion of the vitamin K dependent bone protein from matrix. Endocrinology 118:1642
104. Menon RK, Gill DS, Thomas M, Kernoff PBA, Dandona P 1987 Impaired carboxylation of osteocalcin in Warfarin treated patients. J Clin Endocrinol Metab 64:59
105. Price PA, Nishimoto SK 1980 Radioimmunoassay for the vitamin K dependent protein of bone and its discovery in plasma. Proc Natl Acad Sci USA 77:2234
106. Delmas PD, Stenner D, Wahner HW, Mann KG, Riggs BL 1983 Increase in serum bone Gla protein with aging in women: implications for the mechanism of age-related bone loss. J Clin Invest 71:1316
107. Gundberg CM, Lian JB, Gallop PM 1983 Measurements of car-boxyglutamate and circulating osteocalcin in normal children and adults. Clin Chim Acta 8:1
108. Epstein S, Poser J, McClintock R, Johnston Jr CC, Bryce G, Hui S 1984 Differences in serum bone Gla protein with age and sex. Lancet 1:307
109. Reid IR, Chapman GE, Fraser TRC, Davies AD, Sums AS, Meyer J, Huq NL, Ibbertson HL 1986 Low serum osteocalcin levels in glucocorticoid treated asthmatics. J Clin Endocrinol Metab 62:379
110. Gundberg GM, Wilson PS, Gallop PM, Parfitt AM 1985 Determination of osteocalcin in human serum: results with two kits compared with those by a well-characterized assay. Clin Chem 31:1720
111. Podenphant J, Christiansen C, Catherwood BD, Deftos LJ 1985 Serum bone Gla protein and other biochemical estimates of bone turnover in early postmenopausal osteoporosis during prophylactic treatment for osteoporosis. Acta Med Scand 218:329
112. Gundberg CM, Hauschka PV, Lian JB, Gallop PM 1984 Osteocalcin, characterization and detection. In: Finn W, Kivie M (eds) Methods in Enzymology. Academic Press, New York, vol 107:516
113. Dandona P, Menon RK, Shenoy R, Houlder S, Thomas M, Mullinson WJW 1986 Low 1, 25 dihydroxyvitamin D, secondary hyperparathyroidism and normal osteocalcin in elderly subjects. J Clin Endocrinol Metab 63:459
114. Catherwood BD, Marcus R, Madvig P, Cheung AK 1985 Determinants of bone gamma carboxy glutamic acid containing protein in plasma of healthy aging subjects. Bone 6:9
115. Melick RA, Farrugia W, Quelch KJ 1985 Plasma osteocalcin in man. Aust NZ J Med 15:40
116. Price PA, Parthemore JG, Deftos LJ 1980 A new biochemical marker for bone metabolism. J Clin Invest 66:878
117. Bell NH, Greene A, Epstein S, Oexmann MJ, Shaw S, Shary J 1985 Evidence for alteration of the vitamin D endocrine system in blacks. J Clin Invest 76:470
118. Gundberg CM, Markowitz ME, Mizruchi M, Rosen JF 1985 Osteocalcin in human serum. A circadian rhythm. J Clin Endocrinol Metab 60:736
119. Delmas PD, Wahner HW, Mann KG, Riggs BL 1983 Assessment of bone turnover in post menopausal osteoporosis by measurement of serum bone gla protein. J Lab Clin Med 102:470
120. Yasumura S, Aloia JF, Gundberg CM, Yeh J, Vaswani AN, Yuen K, Lomonte AF, Ellis KJ, Cohn SH 1987 Serum osteocalcin and total body calcium in normal pre and post menopausal women and post menopausal osteoporotic patients. J Clin Endocrinol Metab 64:681
121. Brown JP, Malaval L, Chapuy MC, Delmas PD, Edouard C, Meunier PJ 1984 Serum bone Gla protein, a specific marker for bone formation in postmenopausal osteoporosis. Lancet 1:1091
122. 3 administration raises serum osteocalcin in patients with post menopausal osteoporosis. J Clin Endocrinol Metab 60:615
123. Christiansen C, Riis BJ, Nilas L, Rodbro P, Deftos L 1985 Uncoupling of bone formation and resorption by combined estrogen and progestagen therapy in post menopausal osteoporosis. Lancet 2:800
124. Ismail F, Epstein S, Pacifici R, Droke D, Thomas S, Avioli LV Serum bone Gla protein and other markers of bone mineral metabolism in post menopausal osteoporosis. Calcif Tissue Int 39:230
125. Slemenda C, Hui SL, Longcope C, Johnston Jr CC 1987 Sex steroids and bone mass. Study of changes about the time of menopause. J Clin Invest 80:1261
126. Ismail F, Epstein S, Fallon MD, Thomas S, Reinhardt TA 1988 Serum BGP and the vitamin D endocrine system in the oopho-rectomized rat. Endocrinology 122:624
127. Delmas PD, Demiaux B, Malaval L, Chapuy MC, Edouard C, Meunier PJ 1986 Serum bone gamma carboxyglutamic acid containing protein in primary hyperparathyroidism and in malignant hypercalcemia. J Clin Invest 77:985
128. 3. J Clin Endocrinol Metab 56:1063
129. 3 administration in long term follow-up. Kidney Int 28:783
130. Cole DEC, Gundberg CM 1985 Changes in serum osteocalcin associated with parathyroid hormone infusion in x-linked hypo-phosphatemic rickets. Clin Chim Acta 151:1
131. Riggs BL, Tsai KS, Mann KG 1986 Effect of acute increases in bone matrix degradation on circulating levels of bone Gla protein. J Bone Mineral Res 1:539
132. Calvo MS, Fryer MJ, Laaksa KJ, Nissenson RA, Price PA, Murray TM, Heath III H 1985 Structural requirements for parathyroid hormone action in mature bone. J Clin Invest 76:2348
133. Price PA, Williamson MK, Lothringer JW 1981 Origin of the bone 7 carboxyglutamic acid containing protein found in plasma and its clearance by kidney and bone. J Biol Chem 256:12760
134. Farrugia W, Melick RA 1986 Metabolism of osteocalcin. Calcif Tissue Int 39:234
135. Delmas PD, Wilson DM, Mann KG, Riggs BL 1983 Effects of renal function on plasma levels of bone Gla protein. J Clin Endocrinol Metab 57:1028
136. Epstein S, Traberg H, Raja R, Poser J 1985 Bone Gla protein values in serum dialysate fluid, pre and post hemodialysis and peritoneal dialysis. J Clin Endocrinol Metab 60:1253
137. Gundberg CM, Weinstein RS 1986 Multiple immunoreactive forms of osteocalcin in uremic serum. J Clin Invest 77:1762
138. Fante P, Smith AJ, Price PA, Reitz RE, Malluche HH 1986 Effects of parathyroidectomy on circulating levels of 1, 25-dihy-droxyvitamin D and bone Gla protein in Dialyzed patients. J Clin Endocrinol Metab 62:869
139. Malluche HH, Faugere MC, Fanti P, Price P 1984 Plasma levels of bone Gla protein reflect bone formation in patients on chronic maintenance dialysis. Kidney Int 26:869
140. Sebert JL, Ruiz JC, Fournier A, Fardellone P, Gueries J, Marie A, Moriniere PH, Codet MP, Renaud H 1987 Plasma bone Gla protein: assessment of its clinical value as an index of bone formation in hemodialyzed patients. J Bone Mineral Res 2:21
141. 3 modulates glucocorticoid-induced alteration in serum bone Gla protein and bone histomorphometry. Endocrinology 2:531
142. Lukert BP, Higgins JC, Stoskopf MM 1986 Serum osteocalcin is increased in patients with hyperthyroidism and decreased in patients receiving glucocorticoids. J Clin Endocrinol Metab 62:1056
143. Garrel DR, Delmas PD, Malaval L, Tourniaire J 1986 Serum bone Gla protein: a marker of bone turnover in hyperthyroidism. J Clin Endocrinol Metab 62:1052
144. Body JJ, Deeren A, Pot M, Borkowski A 1986 Serum osteocalcin (BGP) in tumor associated hypercalcemia. J Bone Mineral Res 1:523
145. Slovik DM, Gundberg CM, Neer RM, Lian JB 1984 Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting. J Clin Endocrinol Metab 59:228
146. Jowell PS, Epstein S, Ismail F, Hollis B, Schwartz R 1988 Alteration in osteoblast activity and nutritional vitamin D deficiency in non-hypercalcemic malignancy. Calcif Tissue Int 42:18
147. Bataille R, Delmas PD, Chappard D, Sany J 1987 Heterogenous bone turnover in multiple myeloma. J Bone Mineral Res 2:[Suppl 1] (Abstract 494)
148. Stracke H, Schatz CH, Pralle H, Ullman J, Schatz H 1985 Osteocalcin, ein Marker bei Erkrankungen mit erhöhtem knochenumsatz. Dtsch Med Wochenschr 110:1442
149. Deftos LJ, Parthemore JG, Price PA 1982 Changes in plasma bone Gla protein during treatment of bone disease. Calcif Tissue Int 34:121
150. Delmas PD, Demiaux B, Malaval L, Chapuy MC, Meunier PJ 1986 Serum bone Gla protein is not a sensitive marker of bone turnover in Paget’s disease of bone. Calcif Tissue Int 38:60
151. Wilkinson MR, Wagstaffe C, Delbridge L, Wiseman J, Posen S 1986 Serum osteocalcin concentrations in Pagets disease of bone. Arch Intern Med 146:268
152. 3. In: Veis S (ed) The Chemistry and Biology of Mineralized Connective Tissue. Elsevier, New York, p 327
153. 3 increased synthesis of the Vitamin K dependent bone protein by osteosarcoma cells. J Biol Chem 255:11660
154. Morrison NE, Ramanathan S, Hauschka PV, Suh SM 1986 Osteocalcin release from rat bone in response to parathyroid hormone and calcitonin in vivo. Am Soc Bone Mineral Res 1: [Suppl 1] (Abstract 131)
155. Rico H, Cabranes JA, Nunez-Torron M, Higueras JC, Hernandezy ER 1986 Valores de osteocalcin (BGP) en la osteoporosis pos-menopausica antes y despues del tratamiento con calcitonina. Med Clin (Bare) 86:791
156. Markowitz ME, Gundberg CM, Rosen JF 1986 Serum osteocalcin is a new marker of childhood lead toxicity. Lead inhibits osteocalcin binding to hyroxyappatite in vitro. Am Soc Bone Mineral Res 1: [Suppl 1] (Abstract 133)
157. Delmas PD, Châtelain P, Malaval L, Bonne G 1986 Serum bone Gla protein in growth hormone deficient children. J Bone Mineral Res 1:333
158. Chenu C, Opran V, Delmas P, Chavassieux P, Hartman DJ, Suez S, Meunier PJ 1986 Growth hormone and somatomedin C activity in human osteoblasts in short term culture. Am Soc Bone Mineral Res 1:[Suppl. 1] (Abstract 154)
159. Keith DA, Gundberg CM, Japour A, Aronoff J, Alvarez N, Gallop P 1983 Vitamin K-dependent proteins and anticonvulsant medication. Clin Pharmacol Ther 34:529
160. Lian JB, Steinberg J, Gundberg C, Gallop PM 1980 7-Carboxy-glutamate excretion in osteoporosis and Paget’s disease. Trans Orthop Res Soc 5:70
161. Lian JB, Pachman L, Partridge NEH, Gundberg C, Gallop PM 1979 Carboxyglutamate excretion: a marker in patients with ectopic calcification disorders. Arthritis Rheum 22:634
162. Gundberg CM, Lian JB, Gallop P, Steenberg JS 1983 Urinary 7-carboxyglutamic acid and serum osteocalcin as bone markers: studies in osteoporosis and Paget’s disease. J Clin Endocrinol Metab 57:1221
163. Termine JD, Belcourt AB, Conn KM, Kleinman HK 1981 Mineral and collagen building proteins in fetal calf bone. J Biol Chem 256:10403
164. Romberg RW, Werness PG, Lollar P, Riggs BL, Mann KG 1985 Isolation and characterisation of native osteonectin. J Biol Chem 260:2728
165. Termine JD, Robey P, Fisher LW, Shimokawa H, Drum MA, Conn KM, Hawkins GR, Cruz JB, Thompson RE 1985 Osteonectin, bone proteoglycan and phosphophoryn defects in a form of osteogenesis imperfecta. Proc Natl Acad Sci USA 81:2213
166. Tung PS, Domenicucci C, Wasi S, Sodek J 1985 Specific immu-nohistochemical localization of osteonectin and collagen types I and III in fetal and adult porcine dental tissues. J Histochem Cytochem 33:531
167. Stenner DD, Tracy RG, Riggs BL, Mann KG 1986 Human platelets contain and secrete osteonectin. Proc Natl Acad Sci USA 83:6892
168. Price PA, Williamson MK 1985 Primary structure of bovine matrix Gla protein a new vitamin K dependent bone protein. J Biol Chem 260:14971
169. 3. Am Soc Bone Mineral Res 1:[Suppl 1] (Abstract 289)
170. Fisher LW, Whitson SW, Avioli LV, Termine JD 1983 Matrix sialoprotein of developing bone. J Biol Chem 258:12723
171. Oldberg A, Franzen A, Heinegard D 1986 Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc Natl Acad Sci USA 83:8819
172. Kiang WL, Krusius T, Finne J, Margolis RU, Margolis RR 1982 Glycoprotein and proteoglycans of the chromaffin granule matrix. J Biol Chem 257:1651
173. Prockop DJ, Kivirikko KI 1984 Heritable diseases of collagen. N Engl J Med 311:376
174. Parfitt AM, Simon LS, Villaneuva AR, Krane SM 1987 Procollagen type I carboxyterminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with bone formation rates and comparison with total alkaline phosphatase. J Bone Mineral Res 2:427
175. Taubman MB, Goldberg B, Sherr CJ 1976 Radioimmunoassay of procollagen in serum of patients with Paget’s disease of bone. Proc Soc Exp Biol Med 152:284
176. Simon LS, Krane SM, Wortman PD, Krane M, Kovitz KL 1984 Serum levels of type I and III procollagen fragments in Paget’s disease of bone. J Clin Endocrinol Metab 58:110
177. Canalis E, McCarthy T, Centrella M 1988 Growth factors and the regulation of bone remodeling. J Clin Invest 81:277