Pharmacokinetic Interactions with Digoxin

Clinical Pharmacokinetics

Volumn 15, Issue 4, 1988, Pages 227-244

  Rodin, Steven M ^a   Johnson, Brian F ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN;

DRUG INTERACTION; HUMAN; REVIEW;

DIGOXIN; DRUG INTERACTIONS; HUMAN;

EID: 0024102997     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.2165/00003088-198815040-00003     Document Type: Review

References (175)

1. Amiodarone increases plasma digoxin concentrations. Correspondence
2. Influence of kaolinpectin suspension on digoxin bioavailability
3. Effect of magnesium-aluminum hydroxide and kaolin-pectin on absorption of digoxin from tablets and capsules
4. Diltiazem increases steady-state digoxin levels in patients with cardiac disease
5. Quinidine reduces biliary clearance of digoxin in man
6. Pharmacokinetic drug interactions between digoxin and antiarrhythmic agents and calcium blocking agents: an appraisal of study methodology
7. Rifampin drug interaction
8. Lack of effects of diltiazem on digoxin pharmacokinetics
9. Interaction between digoxin and calcium antagonists and antiarrhythmic drugs
10. Effects of various calciumantagonists on blood level and renal clearance of digoxin
11. Quinidine-digoxin interaction: cardiac efficacy of elevated serum digoxin concentration
12. The quinidine-digoxin interaction
13. Quinidine and digoxin: an important interaction
14. Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations
15. Effect of furosemide on the renal excretion of digoxin
16. Decreased bioavailability of digoxin due to antacids and kaolin-pectin
17. Decreased bioavailability of digoxin due to hypocholesterolemic interventions
18. Effects of hypocholesterolemic interventions on digoxin bioavailability
19. A steady-state evaluation of the effects of propantheline bromide and cholestyramine on the bioavailability of digoxin when administered as tablets or capsules
20. Drug interactions with digoxin
21. The influence of quinidine and other agents on digitalis glycosides
22. Interruption of the enterohepatic circulation of digitoxin by cholestyramine
23. Digoxin levels and diazepam
24. The relationship between cardiotoxicity and plasma digoxin concentration in conscious dogs
25. Alteration of digoxin pharmacokinetics by a single dose of quinidine
26. The effects of captopril on serum digoxin and urinary urea and digoxin clearances in patients with congestive heart failure
27. Acute vasodilator therapy increases renal clearance of digoxin in patients with congestive heart failure
28. Effect of vasodilator therapy on mortality in chronic congestive heart failure
29. Myocardial and skeletal muscle concentrations of digoxin in patients on long-term therapy
30. Effects of enalapril on mortality in severe congestive heart failure
31. Digoxin and cimetidine: investigation of the potential for a drug interaction
32. Effect of quinidine on plasma concentration and renal clearance of digoxin: a clinically important drug interaction
33. Reduction of digoxin effect during the digoxin-quinidine interaction
34. Interaction between mexiletine and digoxin
35. Spironolactone interference with digoxin radioimmunoassay in cirrhotic patients
36. Digoxin-inactivating bacteria: identification in human gut flora
37. Quinidine-digoxin interaction: pharmacokinetics, underlying mechanism and clinical implications
38. Is there a clinically relevant interaction between quinine and digoxin in human beings?
39. 86Rb-uptake of human erythrocytes
40. Quinidine-digoxin interaction: evidence for involvement of an extrarenal mechanism
41. Der einfluss von tiaprofensaure auf diet digoxin-konzentration mim serum
42. Chinidin erhoht den Digoxin-Spiegel
43. Pharmacokinetic interaction study with ramipril and digoxin in healthy volunteers
44. The digoxin-quinidine interaction
45. Is there any interaction between digoxin and enalapril?
46. Effect of quinidine on plasma concentrations of digoxin
47. Effect of diltiazem on renal clearance and serum concentration of digoxin in patients with cardiac disease
48. Kinetics of the digoxin-aspirin combination
49. Digoxin-quinidine-spironolactone interaction
50. Digoxin-quinidine interaction in patients with chronic renal failure
51. Onset and dose dependence of the digoxin-quinidine interaction
52. Pharmacokinetic evaluation of the digoxin-amiodarone interaction
53. Pharmacokinetics of digoxin alone and in the presence of indomethacin therapy
54. Potassium-sparing diuretics: interaction with digoxin in elderly men
55. Digoxin interaction with bran and high fiber foods
56. Effect of cimetidine on steady-state serum digoxin concentrations
57. Erythromycin-induced digoxin toxicity
58. Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration
59. Un altro tipo di interazione fra livelli ematici della digitale e di farmaci antiaritmici: digoxena ed amiodarone
60. Effect of cimetidine on digoxin disposition in peptic ulcer patients
61. Digoxin-rifampin interaction
62. Quinidine and the non-renal elimination of digoxin
63. An electrophysiologic study of the digoxin-quinidine interaction
64. Effect of quinidine on the renal handling of digoxin
65. Effect of a pharmacologic dose of digoxin on inotropy in hyper- and normokalemic dogs
66. Digoxin-quinidine interaction: pharmacokinetic evaluation
67. Digoxin bioavailability during quinidine administration
68. Effect of cholestyramine on digoxin absorption and excretion in man
69. Treatment of digoxin intoxication
70. Digoxin-quinidine interaction in patients with renal failure
71. Further insights into digoxinquinidine interaction: lack of correlation between serum digoxin concentration and inotropic state of the heart
72. Effect of quinidine on plasma concentration of digoxin
73. Current status of cardiac glycoside drug interactions
74. Spironolactone and digoxin
75. Dose-dependence of the nifedipine-digoxin interaction?
76. Der einfluss von tiaprofensaure auf die digoxinkonzentration im serum im vergleich zu anderen antirheumatika
77. Effect of metoclopramide on digoxin absorption from tablets and capsules
78. The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide
79. The effect of dietary fiber on the bioavailability of digoxin in capsules
80. The comparative effects of verapamil and a new dihydropyridine calcium channel blocker on digoxin pharmacokinetics
81. Digoxin-diltiazem interactions: a pharmacokinetic evaluation
82. Non-interaction of cimetidine with digoxin absorption
83. Effect of sulphasalazine on digoxin bioavailability
84. Digoxin-quinidine interaction: in vitro studies in rat tissue
85. Drugs increasing digoxin serum concentrations
86. Serum digoxin concentrations during ethmozine antiarrhythmia therapy
87. Studies on the possible mechanism of lidoflazine arrhythmogenicity
88. The uptake of digoxin and digitoxin by some antacids
89. Treatment of digoxin intoxication with colestipol
90. Dose-dependence of the nifedipine-digoxin interaction?
91. Drug interactions with nitrendipine
92. The influence of verapamil on serum digoxin concentration
93. The beneficial effects of verapamil in chronic atrial fibrillation
94. Interaction between digoxin and nifedipine at steady-state in patients with atrial fibrillation
95. Interaction between digoxin and commonly coadministered drugs on children
96. Pharmacokinetic studies of nifedipine and digoxin co-administration
97. Effects of nifedipine and diltiazem on plasma levels and renal excretion of beta-acetyldigoxin
98. Effects of cytostatic drugs on plasma level and renal excretion of beta-acetyldigoxin
99. Verapamil improves exercise capacity in chronic atrial fibrillation: double-blind cross-over study
100. Quinidine-digoxin interaction: time course and pharmacokinetics
101. Reduced renal clearance of digoxin during chronic quinidine administration
102. Interaction between quinidine and digoxin
103. The effect of quinidine and other oral antiarrhythmic drugs on serum digoxin: a prospective study
104. Enhanced cardiac effect of digoxin during quinidine treatment
105. Interaction between digoxin and the calcium antagonists nicardipine and tiapamil
106. Interaction of flecainide with digoxin and propranolol
107. The effect of oral spironolactone and intravenous canrenoate-K on the digoxin radioimmunoassay
108. Inhibition of digoxin absorption by neomycin
109. Inactivation of digoxin by the gut florae reversal by antibiotic therapy
110. Urinary excretion of reduced metabolites of digoxin
111. The effect of to-cainide on digoxin serum level and renal clearance
112. Assessment of the potential pharmacokinetic interaction between digoxin and ethmozine
113. Digoxin kinetics during furosemide administration
114. Altered absorption of digoxin in patients given propantheline and metoclopramide
115. Effects of quinidine and disopyramide on serum digoxin concentrations
116. Pharmacokinetic interactions between digoxin and other drugs
117. The effect of captopril on serum digoxin concentration in patients with mild congestive heart failure
118. Amiodarone increases plasma digoxin concentrations
119. Effects of quinidine on serum digoxin concentration
120. Renal clearance of digoxin in man after sodium loading or furosemide treatment
121. Amiodarone-digoxin interaction: clinical significance, time course of development, potential pharmacokinetic mechanisms and therapeutic implications
122. Interaktion zwischen amiodaron und digoxin
123. Reduction of absorption of digoxin, phenytoin and aspirin by activated charcoal in man
124. Rifampin and digoxin: possible drug interaction in a dialysis patient
125. Impairment of digoxin clearance by coadministration of quinidine
126. Effect of cimetidine on digoxin kinetics and creatinine clearance
127. Amiodarone-digoxin interaction, clinical and experimental observations
128. Digoxin-diltiazem interaction
129. Use of colestipol in a patient with digoxin intoxication
130. Verapamil-induced changes in digoxin kinetics and intraerythrocytic sodium concentration
131. Effect of quinidine on digoxin bioavailability
132. Digoxin-verapamil interaction
133. The long-term effect of verapamil on plasma digoxin concentration and renal digoxin concentration and renal digoxin clearance in healthy subjects
134. Effect of nifedipine on digoxin kinetics in healthy subjects
135. The effect of quinidine on digoxin kinetics in cardiac patients
136. Non-interaction between nifedipine and digoxin
137. Quinidine-digoxin interaction
138. The effect of ibuprofen on serum digoxin concentration
139. The diltiazem-digoxin interaction
140. Effect of administration of activated charcoal and fibre on absorption, excretion and steady-state blood levels of digoxin and digitoxin
141. On the interaction between digoxin and disopyramide
142. Comparative effects of verapamil and isradipine upon steady-state kinetics
143. Decreased digoxin cardioinactive metabolites after administration of an encapsulated liquid concentrate
144. Effects of amiodarone on oral and intravenous digoxin kinetics in healthy subjects
145. Pharmacokinetics of digoxin in patients subjected to the quinidine-digoxin interaction
146. Cardiac effects of treatment with quinidine and digoxin alone and in combination
147. Effect of quinidine on digoxin concentration in skeletal muscle and serum in patients with atrial fibrillation: evidence for reduced binding of digoxin in muscle
148. Renal function and digoxin clearance during quinidine therapy
149. Diltiazem, digoxin interaction
150. Effect of nifedipine on serum digoxin concentration and renal digoxin clearance
151. The effect of nifedipine on serum digoxin concentrations in patients
152. Verapamil-digitalis interaction: effect on cardiac Purkinje fibers and myocardium
153. Nifedipine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders
154. Renal tubular secretion of digoxin
155. Suppression of renal excretion of digoxin in hypokalemic patients
156. Reduction of digoxin-induced inotropism during quinidine administration
157. Alteration of digitalis binding by quinidine: a mechanism of digitalis-quinidine interaction
158. Relationship of in vitro binding of digoxin to its intestinal absorption in rats
159. Effects of furosemide on glomerular filtration rate and clearance of practolol, digoxin, cephaloridine, and gentaymcin
160. Oral digoxin pharmacokinetics during multiple-dose flecainide treatment
161. Der einfluss von antacida auf die plasmakonzentration von digoxin beim menschen
162. Spironolactone-induced changes in digoxin kinetics
163. Systolic time intervals during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease
164. Interactions between digoxin and potassium-sparing diuretics
165. Amiloride-induced changes in digoxin dynamics and kinetics: abolition of digoxin-induced inotropism with amiloride
166. Drug toxicity in patients receiving digoxin and quinidine
167. The effect of flecainide acetate, a new anti-arrhythmic, on plasma digoxin levels
168. Serum and tissue concentrations of digoxin: a clinical and pathologic analysis
169. Effects of oral disopyramide on serum digoxin levels: a prospective study
170. Lack of effect of bran on digoxin absorption
171. +-carrenoate in man
172. Effects of diltiazem on plasma level and urinary excretion of digoxin in healthy subjects
173. An interaction study between benoxaprofen and digoxin