Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma

Japanese Journal of Clinical Oncology

Volumn 18, Issue 3, 1988, Pages 203-216

  Kohno, Nobuoki ^a   Akiyama, Mitoshi ^a   Kyoizumi, Seishi ^a   Hakoda, Masayuki ^a   Kobuke, Kyoko ^b   Yamakido, Michio ^b  

^a RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Lung cancer; Monoclonal antibodies; Soluble antigens

Indexed keywords

DIAGNOSTIC AGENT; MONOCLONAL ANTIBODY; TUMOR ANTIGEN; TUMOR MARKER;

ADENOCARCINOMA; ANIMAL; ARTICLE; BIOSYNTHESIS; HUMAN; IMMUNOLOGY; LUNG TUMOR; MOUSE; MOUSE STRAIN; PLEURA EFFUSION;

ADENOCARCINOMA; ANIMAL; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; HUMAN; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; PLEURAL EFFUSION; TUMOR MARKERS, BIOLOGICAL;

EID: 0024077916     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Shinkai, T., Saijo, N., Tominaga, K., Eguchi, K., Shimizu, E., Sasaki, Y., Fujita, J., Futami, H., Ohkura, H. and Suemasu, K. Serial plasma carcinoembryonic antigen measurement for monitoring patients with advanced lung cancer during chemotherapy. Cancer 57, 1318-1323 (1986).
2. Masuoka, T., Matsuda, Y., Ookawa, H., Watanabe, K. and Mimoto, S. The measurement of SCC antigen in squamous cell carcinoma of the lung. Gan No Rinsho 31, 914–918 (1985) (in Japanese).
3. Cooper, E.H., Splinter, T. A. W., Brown, D. A., Muers, M. F., Peake, M. D. and Pearson, S. L. Evaluation of a radioimmunoassay for neuron specific enolase in small cell lung cancer. Br. J. Cancer 52, 333-338 (1985).
4. x as a new tumor-associated antigen. Cancer Res. 44, 5279-5285 (1984).
5. Hinoda, Y., Imai, K., Endo, T., Yaniashita, T. and Yachi, A. Detection of circulating adenocarcinoma-associated antigen in the sera of cancer patients with a monoclonal antibody. Jpn. J. Cancer Res. (Gann) 76, 1203–1211 (1985).
6. Kannagi, R., Fukushi, Y., Tachikawa, T., Nöda, A., Shin, S., Shigeta, K., Hiraiwa, N., Fukuda, Y., Inamoto, T., Hakomori, S-I and Imura, H. Quantitative and qualitative characterization of human cancer-associated serum glycoprotein antigens expressing fucosyl or sialyfucosyl type 2 chain polylactosamine. Cancer Res. 46, 2619-2626 (1986).
7. Hanai, N., Shitara, K. and Yoshida, H. Distribution of a squamous cell lung carcinoma-associated antigen, KA-32, in human tissues and sera defined by monoclonal antibody KM-32. Cancer Res. 46, 5206-5210 (1986).
8. Shitara, K., Hanai, N. and Yoshida, H. Distribution of adenocarcinoma-associated antigens in human tissues and sera defined by monoclonal antibodies KM-52 and KM-93. Cancer Res. 47, 1267-1272 (1987).
9. Kyoizumi, S., Akiyama, M., Kohno, N., Kobuke, K., Hakoda, M., Jones, S. L. and Yamakido, M. Monoclonal antibodies to human squamous cell carcinoma of die lung and their application to tumor diagnosis. Cancer Res. 45, 3274-3281 (1985).
10. Köhler, G. and Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497 (1975).
11. Nakane, P. K. and Kawaoi, A. Peroxidaselabelled antibody: A new method of conjugation. J. Hutochem. Cytochem. 22, 1084–1091 (1974).
12. Magnani, J. L., Steplewski, Z., Koprowski, H. and Ginsburg, V. Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin. Cancer Res. 43, 5489-5492 (1983).
13. Magnani, J. L., Brockhaus, M., Smith, D. F., Ginsburg, V., Blaszczyk, M., Mitchell, K. F., Steplewski, Z. and Koprowski, H. A mono-sialoganglioside is a monoclonal antibodydefined antigen of colon carcinoma. Science 212, 55-56 (1981).
14. Metzgar, R. S., Rodriguez, N., Finn, O. J., Lan, M. S., Daasch, V. N., Fernsten, P. D., Meyers, W. C, Sindelar, W. F., Sandler, R. S. and Seigler, H. F. Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) in serum and ascites of patients with adenocarcinoma. Proc. Natl. Acad. Sci. USA 81, 5242-5246 (1984).